Protective effect of antioxidant-enriched diets on T-2-toxin-induced damage in tilapia (Oreochromis niloticus)

Deng, Yijia; Qiu, Mei; Wang, Yaling; Wang, Rundong; Lu, Pengli; Sun, Lijun; Li, Xuepeng; Gooneratne, Ravi

doi:10.1016/j.aquaculture.2019.03.066

Cited by 26 publications

(19 citation statements)

References 52 publications

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“…and enhanced the GST activity in liver of tilapia exposed to mycotoxin (T-2) (Deng et al, 2019). In addition, the supplementation of rutin in the diets (0.15% and 0.30%) of silver catfish significantly reduced the lipid peroxidation and increased the activity of SOD and GST in the brain and liver of silver catfish (Pês et al, 2016).…”

Section: Discussionmentioning

confidence: 97%

“…The protective effect and antioxidant effect of rutin were also reported in silver catfish ( Rhamdia quelen ) (Pês et al., 2016; Londero et al . 2020; Baldissera et al., 2020) and tilapia ( Oreochromis niloticus ) (Deng et al., 2019). In addition, the addition of rutin in tilapia diet improved the growth and reduced liver and myofibre damage induced by mycotoxin (T‐2) (Deng et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

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Dietary rutin promoted the growth, serum antioxidant response and flesh collagen, free amino acids contents of grass carp ( Ctenopharyngodon idella )

Yang

et al. 2020

Aquacult. Nutr.

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Food from aquaculture makes an important contribution to human nutrition and health. Maintaining the sustainable aquaculture production is a continuing challenge for society (Jennings et al., 2016). At present, the potential application of natural products and plant extracts is attracting more and more attentions in aquaculture (Reverter et al., 2014). Rutin is a natural flavone derivative widely existing in plants such as buckwheat, eucommia and tomatoes, which consists of disaccharide 6-o-l-rhamnosyl-d-glucose and aglycone (Figure 1). Rutin has been reported some biological activities, including antioxidation (Machawal & Kumar, 2014), anti-inflammatory (Yang et al., 2008), neuroprotective, anti-viral (Aron & Kennedy, 2008) and anti-carcinogenic effects (Javed et al., 2012). The supplementation of rutin in diets attenuated the expressions of IL-1b and IL-6 mRNA in colonic mucosa and ameliorated DSS (dextran sulphate sodium)-induced colitis by suppressing pro-inflammatory cytokines in mice (Kwon et al., 2005). Dietary rutin also decreased thiobarbituric acid reactive substances and lipid hydroperoxides and increased the non-enzymic antioxidants in rats (Kamalakkannan, & Prince, 2006).

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Dietary rutin promoted the growth, serum antioxidant response and flesh collagen, free amino acids contents of grass carp ( Ctenopharyngodon idella )

Yang

et al. 2020

Aquacult. Nutr.

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“…In addition, they are often called detoxification enzymes or antioxidant enzymes. A study showed that T-2 could inhibit SULT/NATs in all tissues and organs of prawn, GSTs/UGT in the muscle and head of prawn, and MT in the blood (Deng et al 2019). Quercetin, rutin and tea polyphenols can induce the gene expression of these key enzymes or increase their enzyme activity to effectively reduce the development of diseases caused by T-2 (Deng et al 2019).…”

Section: Phase II Metabolizing Enzymesmentioning

confidence: 99%

“…A study showed that T-2 could inhibit SULT/NATs in all tissues and organs of prawn, GSTs/UGT in the muscle and head of prawn, and MT in the blood (Deng et al 2019). Quercetin, rutin and tea polyphenols can induce the gene expression of these key enzymes or increase their enzyme activity to effectively reduce the development of diseases caused by T-2 (Deng et al 2019). In plants, phase II metabolism is characterized by detoxification owing to conjugation reactions that take place through the combination of hydrophilic biomolecules with T-2 or phase I metabolic products, catalyzed by glycosyl-transferases, malonyl-transferases and GSTs (Freire and Sant'Ana 2018).…”

Section: Phase II Metabolizing Enzymesmentioning

confidence: 99%

An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment

Qin

Kuča

et al. 2020

Arch Toxicol

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T-2 toxin is the most toxic trichothecene mycotoxin, and it exerts potent toxic effects, including immunotoxicity, neurotoxicity, and reproductive toxicity. Recently, several novel metabolites, including 3′,4′-dihydroxy-T-2 toxin and 4′,4′-dihydroxy-T-2 toxin, have been uncovered. The enzymes CYP3A4 and carboxylesterase contribute to T-2 toxin metabolism, with 3′-hydroxy-T-2 toxin and HT-2 toxin as the corresponding primary products. Modified forms of T-2 toxin, including T-2-3-glucoside, exert their immunotoxic effects by signaling through JAK/STAT but not MAPK. T-2-3-glucoside results from hydrolyzation of the corresponding parent mycotoxin and other metabolites by the intestinal microbiota, which leads to enhanced toxicity. Increasing evidence has shown that autophagy, hypoxia-inducible factors, and exosomes are involved in T-2 toxin-induced immunotoxicity. Autophagy promotes the immunosuppression induced by T-2 toxin, and a complex crosstalk between apoptosis and autophagy exists. Very recently, "immune evasion" activity was reported to be associated with this toxin; this activity is initiated inside cells and allows pathogens to escape the host immune response. Moreover, T-2 toxin has the potential to trigger hypoxia in cells, which is related to activation of hypoxia-inducible factor and the release of exosomes, leading to immunotoxicity. Based on the data from a series of human exposure studies, free T-2 toxin, HT-2 toxin, and HT-2-4-glucuronide should be considered human T-2 toxin biomarkers in the urine. The present review focuses on novel findings related to the metabolism, immunotoxicity, and human exposure assessment of T-2 toxin and its modified forms. In particular, the immunotoxicity mechanisms of T-2 toxin and the toxicity mechanism of its modified form, as well as human T-2 toxin biomarkers, are discussed. This work will contribute to an improved understanding of the immunotoxicity mechanism of T-2 toxin and its modified forms. Keywords T-2 toxin • Modified T-2 toxin • Metabolism • Immunotoxicity • Human exposure assessments • Biomarkers Abbreviations AhR Aryl hydrocarbon receptor AKNA AT-hook transcriptionfactor Akt Serine/threonine protein kinase ARE Antioxidant response element CREB CAMP-response clement-binding protein CYP450 Cytochrome P450 DAS Diacetoxyscirpenol DRP-1 Dynamin-related protein 1 DON Deoxynivalenol D3G Deoxynivalenol-3-glucoside ECM Extracellular matrix EIF2AK2 Double-stranded RNA-activated protein kinase ERK Etracellular signaling kinase FXR Farnesoid X receptor GH Growth hormone Qinghua Wu and Zihui Qin contributed equally to this work.

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“…The use and consumption of feed at a global level in aquaculture activities is increasing due to availability and profitability, and where tilapia production is no exception (FAO, 2018). And the tilapia culture is prone to mycotoxin exposure through its diet with negative effects on aquaculture production, health, and safety (Deng et al, 2019).…”

Section: Tilapiamentioning

confidence: 99%

Gıda, Balık ve Mikotoksinler

Sanchez

Torres

Espinosa-Chaurand

2020

Acta Aquatica Turcica

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Due to their incidence and negative effects on public health, foodborne diseases are considered an issue of international relevance. Fish is considered a nutritious food and highly susceptible to contamination by physical, chemical, and biological agents responsible for diseases in animals and humans. Mycotoxins are biological contaminants of food with various harmful effects on human and animal health derived from their consumption, concentration, and exposure time. The presence of mycotoxins has been reported in different foods, mainly cereals, which are intended for human and animal consumption, such as feed processing. The presence of mycotoxins in fish is generally by way of feeding by supplying contaminated feed in aquaculture production activities, and the transfer can be generated in the food chain and affect human health. The objective of this bibliographic review is to provide relevant general information about mycotoxins in foods including fish, harmful effects on fish, especially tilapia, prevention, control, and regulation of these contaminants in foods intended for human and animal consumption, its negative impact on animal production and health, as well as human health through its transfer in the food chain.

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Protective effect of antioxidant-enriched diets on T-2-toxin-induced damage in tilapia (Oreochromis niloticus)

Cited by 26 publications

References 52 publications

Dietary rutin promoted the growth, serum antioxidant response and flesh collagen, free amino acids contents of grass carp ( Ctenopharyngodon idella )

Dietary rutin promoted the growth, serum antioxidant response and flesh collagen, free amino acids contents of grass carp ( Ctenopharyngodon idella )

An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment

Gıda, Balık ve Mikotoksinler

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