Protective effect of an antineutrophil antibody, Urge-8, on liver ischemia-reperfusion injury in a new hepatic ischemia model

Chen, Y.X; Sato, Mariko; Abe, Yuji; Kito, Katsumi; Watanabe, Yuji; Tokui, Kazuyoshi; Kashu, Yasuaki; Yamamoto, Takumi; Kohtani, Takashi; Nakata, Yutaka; Kawachi, Kanji

doi:10.1016/s0041-1345(00)01680-8

Cited by 5 publications

(9 citation statements)

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“…URGE-8 reacts with a 45-kD cell surface antigen expressed primarily on peripheral neutrophils and also on monocytes and lymphocytes. 26,27 This antibody has been used to study the function of neutrophils in acute pancreatitis, acute respiratory distress syndrome, acute myocardial infarction, and acute hepatic failure, in which it can experimentally protect the liver against ischemia-reperfusion injury. 26,27 In the present study, URGE-8 inhibited neutrophil adhesion and infiltration in the vein graft.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 This antibody has been used to study the function of neutrophils in acute pancreatitis, acute respiratory distress syndrome, acute myocardial infarction, and acute hepatic failure, in which it can experimentally protect the liver against ischemia-reperfusion injury. 26,27 In the present study, URGE-8 inhibited neutrophil adhesion and infiltration in the vein graft. With no neutrophils present, PDT application to the vein graft did not result in thrombosis.…”

Section: Discussionmentioning

confidence: 99%

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Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Nigri

Kossodo

Waterman

et al. 2004

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Nigri

Kossodo

Waterman

et al. 2004

Journal of Vascular Surgery

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“…Urge-8 treatment eliminated inflammatory reactions in MI including activation of neutrophils and the cytokine network, as in cases of antiprotease treatment for I/R injury [8,9]. Eliminated inflammatory reaction and inhibition of neutrophil degradation potentially provide better maintenance of MAP and BT.…”

Section: Discussionmentioning

confidence: 99%

“…Since Urge-8 treatment eliminated inflammatory reactions in MI including suppression of chemotaxis, inhibition of neutrophil degranulation, and antiprotease treatment for I/R injury [8,9], Urge-8 treatment decreased neutrophil infiltration into the myocardium, which was manifested by the histopathological findings.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Anti-Neutrophil Antibody against Myocardial Ischemia/Reperfusion Injury in Rats

Kohtani¹,

Abe

Satô³

et al. 2002

Eur Surg Res

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Neutrophil activation initiates myocardial ischemia/reperfusion (I/R) injuries. The aim of this study is to evaluate the in vitro functions of an anti-neutrophil monoclonal antibody, Urge-8, and its therapeutic efficacy against myocardial ischemia (MI) in rats. We measured in vitro functions of rat neutrophils including chemotactic activity, superoxide production, phagocytic function, and neutrophil degranulation. MI was induced in Wistar rats by clamping the left coronary artery for 1 h. Rats received either isotype-negative control IgG₁ (control group, n = 20), 250 µg/kg of Urge-8 before (pre-treatment group, n = 20) or after (post-treatment group, n = 20) MI. The three groups were compared during the first 24 h after reperfusion with respect to changes in mean arterial pressure, heart rate, body temperature, biochemistry, serum cytokines, myocardial neutrophil infiltration, survival rate, and size of MI. Urge-8 effectively suppressed in vitro functions of rat neutrophils including chemotactic activity, superoxide production, phagocytic function, and neutrophil degranulation. The Urge-8 treated groups showed higher levels of arterial pressure and survival rate, lower values of interleukin-6 and interleukin-8, lower grade of myocardial neutrophil infiltration, and smaller MI size as compared to the control group. In conclusion, Urge-8 is effective against myocardial I/R injury by suppressing certain functions and myocardial infiltration of neutrophils in rats.

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Forty Years of Publication of Transplantation Proceedings—The Fourth Decade: Globalization of the Enterprise

Kahan

2011

Transplantation Proceedings

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Protective effect of an antineutrophil antibody, Urge-8, on liver ischemia-reperfusion injury in a new hepatic ischemia model

Cited by 5 publications

References 5 publications

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Protective Effects of Anti-Neutrophil Antibody against Myocardial Ischemia/Reperfusion Injury in Rats

Forty Years of Publication of Transplantation Proceedings—The Fourth Decade: Globalization of the Enterprise

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