Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Nigri, Giuseppe; Kossodo, Sylvie; Waterman, Peter; Fungaloi, Patrick; LaMuraglia, Glenn M.

doi:10.1016/j.jvs.2003.11.028

Cited by 15 publications

(11 citation statements)

References 33 publications

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“…Furthermore, it destroys the immunity system of the body and develops a wide range of diseases such as atherosclerosis, angina pectoris, Alzheimer’s disease, Parkinson’s disease, complication in diabetes, rheumatoid arthritis, cardiovascular disease, liver diseases, renal failure, DNA damage, cancer, aging, metabolic disorders, etc. [ 9 , 22 , 23 , 24 ]. In this regard, antioxidants can play a vital role in which they fight against free radicals and protect us from various diseases.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

et al. 2017

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This study was conducted to evaluate the in vitro polyphenol content, antioxidant, cytotoxic, antibacterial, anthelmintic properties, and in vivo antinociceptive activity of the ethanol extract of Cissus adnata leaves (EECA) in different experimental models. Polyphenol contents were investigated using spectrophotometric techniques. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) radical-scavenging, ferric reducing power, and total antioxidant capacity assays. Cytotoxicity was determined by brine shrimp lethality bioassay and disc diffusion method was used for the antibacterial activity. Anthelmintic activity was studied using aquarium worm (Tubifex tubifex) whereas antinociceptive activity was evaluated in mice by acetic acid and formalin test. Phytochemical screening of EECA revealed the presence of alkaloids, carbohydrates, flavonoids, phenols, terpenoids, saponins, and tannins. EECA showed strong antioxidant activity with high polyphenol contents. It was observed that EECA possessed significant antibacterial activity with a low toxicity profile. EECA also demonstrated dose-dependent and statistically significant anthelmintic and antinociceptive activities. Our study shows that ethanol extract of C. adnata leaves possess strong antioxidant, antibacterial, anthelmintic and antinociceptive activities with lower toxicity. Further studies are needed to identify bioactive phytomolecules and to understand the mechanism of such actions better.

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Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

et al. 2017

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“…Excess generation of free radicals can destroy the immune system and develop a wide range of diseases. [27][28][29] To minimize the complications generated by free radicals, the intake of antioxidants might be very beneficial. Antioxidant produces its effect either by protecting the antioxidant defense mechanisms or scavenging the reactive oxygen species (ROS).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of in vitro Antioxidant and Cytotoxic Effect of Methanol Extract from aerial parts of Myristica beddomei King ssp. ustulata W.J. de Wilde

Joy

Mohan

2020

Int. J. Pharm. Sci. Drug Res.

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Plants are traditionally used for pharmacological activities because of its ability to produce bioactive compounds. Myristica beddomei King ssp. ustulata W.J. de Wilde is an ethnomedicinal plant and it is seen in South Western Ghats of Kerala, India. The present study assessed the phenolic content, flavonoid concentration, in vitro antioxidant and cytotoxic effect of different parts of Myristica beddomei King. The total phenolic contents in the extracts ranged from 96.29 (pericarp) to 314.47 (bark) mg g-1 gallic acid equivalent. The concentration of flavonoids in different plant part extracts ranged from 1.81 to 2.76 mg g-1 equivalent to quercetin. All the parts exhibited potential antioxidant activity with an IC50 value of 2.87 to 9.67 μg ml-1 when compared to the standard ascorbic acid with an IC50 value of 2 μg ml-1 in 1,1-diphenyl-2- picryl-hidrasil (DPPH) method. Bark showed highest activity in terms of DPPH radical scavenging (IC50 value of 2.87 µg ml-1), phosphomolybdenum test (2261.33 ± 1.65 mg g-1 trolox equivalent) and ferric ion reducing antioxidant power (FRAP) (113.1 ± 0.28 µmol Fe2+ µg-1) while pericarp showed low antioxidant activity. The in vitro screening results revealed that the seeds exhibited promising anticancer activity compared to PA1 (Ovarian Cancer) cells (50 % inhibition) were observed at a concentration 100.68 µg ml-1. In cytotoxicity test L929 (Fibroblast) cell line compared to the other parts pericarp, mace and seed needed higher concentration (>240 µg ml-1) for LC50 value. It is a promising plant for further development of antioxidant agent as it got high content of phenolic compounds and potential antioxidant and anticancer activity.

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“…They can destroy immunity system and develop a wide range of diseases such as alzheimer's disease, parkinson's disease, complication in diabetes, rheumatoid arthritis, neuro-degeneration, cardiovascular complications, DNA damage, carcinogenesis, metabolic disorders, aging, etc. [ 36 , 37 ]. To counteract the complications generated by free radicals, antioxidants might be very beneficial.…”

Section: Discussionmentioning

confidence: 99%

In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh

Chaity

Khatun

Rahman

2016

BMC Complement Altern Med

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BackgroundDrynaria quercifolia L. (Family- Polypodiaceae) is a fern grows in Bangladesh used in traditional healing by the Garo tribe of Mymensingh district. In the current study, rhizomes and fertile foliage fronds of this plant have been investigated comprehensively to assess their in vitro membrane stabilizing, thrombolytic and antioxidant properties.MethodsRhizomes and fertile foliage fronds of D. quercifolia were collected, dried, powdered and extracted with methanol. Later on, crude methanol extracts of the plant parts were fractionated into petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions. The extractives were then subjected to membrane stabilizing, thrombolytic and antioxidant assays.ResultsIn membrane stabilizing assay, crude methanol extracts of rhizomes and fertile foliage fronds and their petroleum ether fractions were found to be very effective for stabilizing erythrocyte membrane in hypotonic solution. In case of thrombolytic study, crude methanol extract of rhizomes and its aqueous fraction exhibited noticeable clot lysis. However, in antioxidant assays, crude methanol extracts of the tested plant parts and their aqueous fractions exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide and 2, 2’-azinobis (3-ethylbenzothiazoline sulphonic acid) (ABTS) radical scavenging activity. Besides, these extractives also displayed substantial ferric reducing potential in ferric reducing antioxidant power (FRAP) assay. Crude methanol extracts of the plant parts and their aqueous fractions were also found rich in phenolics.ConclusionThis study demonstrates the medicinal potentials of D. quercifolia and justifies the local uses of it by the Garo tribal people of Bangladesh for multiple disease management.

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Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia

Abstract: OH- radicals and neutrophils both have key roles in PDT-induced vein graft thrombosis. By inhibiting free radical production or neutrophil adhesion to the graft, adequate PDT can be administered for successful inhibition of vein graft intimal hyperplasia.

Cited by 15 publications

References 33 publications

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

Evaluation of in vitro Antioxidant and Cytotoxic Effect of Methanol Extract from aerial parts of Myristica beddomei King ssp. ustulata W.J. de Wilde

In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh

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