Protective effect of alpha-lipoic acid and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity in rats

Nair, Dhanya Venugopalan; Rani, Munuswamy Usha; Reddy, A Gopala; Kumar, Brijesh; Reddy, M. Anudeep; Lakshman, M; Rajkumar, U.

doi:10.14202/vetworld.2020.188-196

Cited by 15 publications

(14 citation statements)

References 61 publications

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“…Previous studies have noted that ALA can enhance the antioxidants enzymes like superoxide dismutase, by reducing the substrate and free radicals to promote the lipid stability in birds (Kofuji, Nakamura, Nakamura, Isobe, Murata, & Kawashima, 2008;Li et al, 2019 (Liu, Lin, Mi, Li, et al, 2018;Liu, Lin, Mi, Zeng, et al, 2018). ALA has been reported to increase the reproductive hormones in ovarian oxidative damage rats (Nair et al, 2020). In the present study, 600 mg/kg ALA supplementation for aged breeder hens increased the level of E2 in the serum significantly.…”

Section: Discussionsupporting

confidence: 59%

“…Several studies have indicated that egg‐laying rates have a positive correlation with blood oestrogen levels (Liu, Lin, Mi, Li, et al, 2018; Liu, Lin, Mi, Zeng, et al, 2018). ALA has been reported to increase the reproductive hormones in ovarian oxidative damage rats (Nair et al., 2020). In the present study, 600 mg/kg ALA supplementation for aged breeder hens increased the level of E2 in the serum significantly.…”

Section: Discussionmentioning

confidence: 99%

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Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Dai

et al. 2020

Animal Physiology Nutrition

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Breeder hens in the late egg-laying period have lower reproductive performance, manifesting as degraded egg-laying rate, quality and hatching performance. The production performance of laying hens is influenced by breeder hens (Gong et al., 2019; Lang et al., 2019). The Qiling hen, used in the present study, is a Chinese native chicken. It is worth mentioning that, the reproductive performance of these local hens decreases rapidly in the late egg-laying period. Therefore, it is of great significance to find a solution to this problem from the perspective of nutritional regulation. In poultry, many factors are in connection with fertility.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Dai

et al. 2020

Animal Physiology Nutrition

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“…By contrast, ALA can reduce the level of ROS [51], thereby reducing the rate of apoptosis and allowing oocyte maturation, growth, and development into the large follicles. ALA can be converted into EPA and DHA, which are the precursors of 3-series prostaglandin and therefore have anti-inflammatory effects [6,52]. This mechanism could explain how ALA increases the number of large follicles.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of follicle growth and development during estrus in Ettawa Grade does fed a flushing supplement of different polyunsaturated fatty acids

et al. 2021

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Background and Aim: Flushing with the manipulation of fatty acids, particularly polyunsaturated fatty acids, like linoleic and α-linolenic acids in the ration, is a strategy to raise the nutritional status of the female mammals to improve ovarian function and follicle development. This study was designed to investigate the effectiveness of flushing supplementation with different types of polyunsaturated and saturated fatty acids in stimulating follicle growth and development during estrus in Ettawa Grade does with a low initial body condition score (BCS ≤2). Materials and Methods: Eighteen Ettawa Grade does in the second parity, with an average body weight of 32.11±2.19 kg, were divided into three groups according to the fatty acid supplemented to their ration: (i) About 2.8% lauric acid flushing (group); (ii) 2.8% linoleic acid flushing (LA group); and (iii) 2.8% a-linolenic acid flushing (ALA group). The ration was formulated to be isocaloric (total digestible nutrient = 77%) and isonitrogenous (crude protein = 15%). The experiment was conducted for 35 days; that is, 14 days for acclimatization and synchronization of the estrous cycle and 21 days for fatty acid flushing until the appearance of the next estrus. A completely randomized design was applied. Results: According to the results, none of the different fatty acids in the ration affected the nutrient intakes, BCSs, average daily gains, and plasma glucose, cholesterol, and progesterone concentrations of the three groups of does. However, the BCSs (by 0.8-0.9) and the plasma cholesterol concentrations were higher after fatty acid flushing for 21 days than before the flushing period. The ALA group had the highest number of large-sized preovulatory follicles, whereas the LAURIC group had the highest plasma estradiol concentration during estrus. All three groups had similar plasma progesterone concentrations during estrus after fatty acid flushing. Conclusion: Flushing supplementation with 2.8% ALA from flaxseed oil gave the best results in terms of stimulating the highest number of large-sized preovulatory follicles in Ettawa Grade does.

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“…11 Nair et al showed that cyclophosphamide-induced damage in the ovarian tissue was caused by a decrease in the endogenous antioxidant glutathione (GSH) and an increase in proinflammatory tumor necrosis factor alpha (TNF-α). 12 In a study by Khedr, it was emphasized that cyclophosphamide-induced infertility was associated with an increase in malondialdehyde (MDA) -a lipid peroxidation (LPO) product in the ovarian tissue. 13 The information obtained from the literature suggests that antioxidant and anti-inflammatory drugs can be beneficial in the prevention or treatment of cyclophosphamide-induced infertility.…”

Section: Introductionmentioning

confidence: 99%

Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats

Özer¹,

İnce²,

Gündoğdu³

et al. 2022

Adv Clin Exp Med

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Background. Cyclophosphamide is a drug used in various types of cancer. It can cause oxidative and inflammatory ovarian damage and infertility. Thiamine pyrophosphate (TPP) to be investigated for its effect on cyclophosphamide-induced ovarian damage and reproductive dysfunction in the present study is the active metabolite of thiamine. It has been shown that TPP protects organs and tissues from oxidative stress and proinflammatory cytokine damage. Objectives.To investigate the effect of TPP against the ovarian damage and reproductive dysfunction caused by cyclophosphamide in rats. Materials and methods.Albino Wistar type female rats were divided into healthy control (HG), cyclophosphamide (CYC) and TPP + cyclophosphamide (TPPC) groups (for each group, n = 12). Thiamine pyrophosphate at a dose of 25 mg/kg was injected intraperitoneally (ip.) in the TPPC group, and 0.9% NaCI solution was injected ip. in the CYC and HG groups. One hour after the injection, 75 mg/kg of cyclophosphamide was administered ip. in the TPPC and CYC groups. This procedure was repeated once a day for 30 days. At the end of this period, 6 rats from each group were euthanized with a high dose of anesthetic (50 mg/kg of sodium thiopental). Biochemical and histopathological examinations were performed on the extracted ovarian tissue. The remaining animals were kept in the laboratory with mature male rats for 2 months for reproduction.Results. Thiamine pyrophosphate significantly decreased the cyclophosphamide-induced increase in the levels of the oxidant parameter malondialdehyde (MDA), proinflammatory nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β). In addition, TPP decreased the severe histopathological damage associated with cyclophosphamide in the ovarian tissue and prevented infertility. Conclusions.Our experimental results have suggested that TPP could be beneficial in the treatment of cyclophosphamide-induced ovarian injury and infertility.

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Protective effect of alpha-lipoic acid and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity in rats

Cited by 15 publications

References 61 publications

Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Stimulation of follicle growth and development during estrus in Ettawa Grade does fed a flushing supplement of different polyunsaturated fatty acids

Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats

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