Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Dai, Hongjian; Lv, Zengpeng; Hu, Chenhui; Wei, Xie; Song, Jihyun; Yuan, Yunwei; Yu, Debing; Shi, Fangxiong

doi:10.1111/jpn.13423

Cited by 11 publications

(13 citation statements)

References 51 publications

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“…In the current study, dietary supplementation with HF improved the laying performance of aged breeder hens during the late period of the experiment. Several studies have indicated that egg-laying rates have a positive correlation with blood estrogen levels ( Long et al, 2017 ; Dai et al, 2020 ). Herein, we found that dietary HF increased the serum estrogen levels.…”

Section: Discussionmentioning

confidence: 99%

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Dai

Huang

et al. 2021

Poultry Science

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Hawthorn-leaves flavonoids ( HF ), extracted from hawthorn leaves, were reported to exert antioxidant, anti-inflammatory and hypolipidemic properties. The aim of our study was to investigate the effects of dietary HF on the reproduction performance and liver lipid metabolism of aged breeder hens. A total of 270 aged Qiling breeder hens (60-wk-old) were randomly divided into 3 treatments: 1) basic corn-soybean diet ( CON ); 2) basic corn-soybean diet supplemented with 30 mg/kg HF ( LHF ); 3) basic corn-soybean diet supplemented with 60 mg/kg HF ( HHF ). The results showed that supplemented HF significantly improved the egg-laying rate and hatching rate of aged breeder hens ( P < 0.05). HF treatment reduced the serum TG, T-CHO and L-LDL levels ( P < 0.05), and upregulated the mRNA expressions of ESR1, ESR2, VTGⅡ, ApoB , and ApoVI in the liver ( P < 0.05). Serum estrogen levels in HF treated groups were elevated compared with the CON group ( P < 0.05). In the HHF group, the number of the primordial follicles was higher in comparison with the CON group ( P < 0.05). Furthermore, dietary supplementation with HF improved the activity of antioxidant enzymes (T-AOC, GSH-Pχ) ( P < 0.05), following with the reversed ovarian apoptosis and morphological damage. In addition, 60 mg/kg dietary HF upregulated the protein expression of PCNA and Nrf2 in the ovary ( P < 0.05). In summary, dietary supplementation with HF could improve the reproduction performance through regulating liver lipid metabolism and improving ovarian function in aged breeder hens.

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Section: Discussionmentioning

confidence: 99%

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Dai

Huang

et al. 2021

Poultry Science

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“…As a strong antioxidant, we believe that LAM has a beneficial effect on egg production performance in laying hens, and similarly our experiments have demonstrated that the dietary supplementation of LAM significantly improved egg-laying rate and egg production in old laying hens. In addition, a study found that addition of LA to the diet increased egg-laying rate, but the difference was not significant ( 30 ). Taken together, the results suggested that LAM may be more effective than LA in poultry production.…”

Section: Discussionmentioning

confidence: 99%

“…Egg production is the main factor limiting the efficiency of egg utilization during the late egg-laying period, while ovary and oviduct aging is the main reason for the decline in egg production ( 31 , 32 ). Oxidative stress is deemed to be one of the dominant mechanisms underlying ovarian and oviduct aging ( 30 ). A stress experiment in rats found that chronic stress could increase MDA concentration and elicit an irreversible decrease in antioxidant defense in the oviduct ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Lipoamide Alleviates Oxidized Fish Oil-Induced Host Inflammatory Response and Oxidative Damage in the Oviduct of Laying Hens

Liu

Zhang

et al. 2022

Front. Vet. Sci.

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Fish oil (FO) is an important source of lipid in functional food and aquafeeds. However, the harmful effects of oxidized fish oil (OFO) on host metabolism and reproductive health are not yet clear. In addition, lipoamide (LAM) has been widely studied as an agent for alleviating various diseases associated with oxidative disruption. Therefore, in the current study, to investigate the effects of LAM in alleviating OFO-induced decline in reproductive performance and oxidative damage to the oviduct in laying hens. We constructed a 1% fresh FO model, a 1% OFO model, and a LAM model with 0.1% OFO (OFO + LAM) added at 100 mg/kg to explore the antioxidant effect of LAM. Herein, these results were evaluated by breeding performance, immune responses, estrogen, and antioxidant indices of serum samples, as well as the number of follicles and antioxidant parameters of oviducts. From the results, compared with the FO group, OFO significantly decreased the egg-laying rate, increased the contents of total protein (TP) and inflammatory factors [tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, and interferon γ (INF-γ)], and reduced the concentrations of anti-oxidation [total antioxidant (T-AOC), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), glutathione (GSH), glutathione reductase (GR), catalase (CAT), and hydroxyl radical scavenging activity (HRSA)] in serum samples, as well as reduced the levels of anti-oxidation indexes in oviduct tissues (p < 0.05). Of note, the supplementation of LAM could significantly increase the laying performance, improve the levels of serum immunoglobulins (IgA, IgG, and IgM), serum estrogen [progesterone (P) and estradiol (E2)], and serum antioxidant parameters (T-AOC, T-SOD, GSH-Px, GSH, GR, CAT, and HRSA) and decrease the concentrations of serum inflammatory cytokines (TNF-α, IL-6, IL-8, and INF-γ) in laying hens following OFO administration (p < 0.05). In addition, LAM could dramatically increase the contents of antioxidant factors (p < 0.05) in oviducts and enhance the secretion capacity of the uterine part. Taken together, OFO caused host metabolic dysfunction, oxidative damage, uterine morphological abnormalities, and alterations of ovarian function. These results suggested that LAM administration could alleviate host metabolic dysfunctions and inflammatory damage, and then ameliorate oxidative damage in the oviduct induced by OFO, ultimately improving reproductive function.

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“…In laying hens’ breeding and production, multiple antioxidants such as polyphenols, flavonoids, and vitamins have been used to alleviate oxidative stress in order to maintain the health of laying hens in production [ 41 , 42 , 43 ]. Likewise, ALA is a multifunctional antioxidant that can scavenge free radicals [ 44 , 45 ]. They are widely used in production because they have an amphiphilic property and can also interact with other antioxidants without any serious side effects when used [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…They are widely used in production because they have an amphiphilic property and can also interact with other antioxidants without any serious side effects when used [ 46 ]. Dai et al indicated that dietary supplementation with 600 mg/kg ALA alone could improve the activity of the SOD and T-AOC and decrease the MDA levels in hens’ ovarian tissue [ 45 ]. It is generally believed that ALA is mostly used to alleviate tissue and organ damage caused by oxidative stress and to mitigate the negative effects on the health of the organism.…”

Section: Discussionmentioning

confidence: 99%

R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens

Liu

Huang

et al. 2022

Antioxidants

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The development of single enantiomers with high efficiency and low toxic activity has become a hot spot for the development and application of drugs and active additives. The aim of the present study was to investigate the effectiveness of the application of α-lipoic acid with a different optical rotation to alleviate the inflammation response and oxidative stress induced by oxidized fish oil in laying hens. Sixty-four 124-week-old Peking Red laying hens were randomly allocated to four groups with eight replicates of two birds each. The normal group was fed basal diets supplemented with 1% fresh fish oil (FO), and the oxidative stress model group was constructed with diets supplemented with 1% oxidized fish oil (OFO). The two treatment groups were the S-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + S-LA) and the R-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + R-LA) added at 100 mg/kg, respectively. Herein, these results were evaluated by the breeding performance, immunoglobulin, immune response, estrogen secretion, antioxidant factors of the serum and oviduct, and pathological observation of the uterus part of the oviduct. From the results, diets supplemented with oxidized fish oil can be relatively successful in constructing a model of inflammation and oxidative stress. The OFO group significantly increased the levels of the serum inflammatory factor (TNF-α, IL-1β, IL-6, and IFN-γ) and the oxidative factor MDA and decreased the activity of the antioxidant enzyme (T-AOC, T-SOD, GSH-Px, GSH, and CAT) in the oviduct. The addition of both S-LA and R-LA significantly reduced the levels of serum inflammatory factors (TNF-α, IL-1β, IL-6, and IFN-γ), increased the activity of antioxidant indexes (T-AOC, T-SOD, GSH-Px, GSH, and CAT), and decreased the MDA contents in the serum and oviduct. Meanwhile, the supplementation of S-LA and R-LA also mitigated the negative effects of the OFO on the immunoglobulins (IgA and IgM) and serum hormone levels (P and E2). In addition, it was worth noting that the R-LA was significantly more effective than the S-LA in some inflammatory (IL-1β) and antioxidant indices (T-SOD, GSH, and CAT). Above all, both S-LA and R-LA can alleviate the inflammation and oxidative damage caused by oxidative stress in aged laying hens, and R-LA is more effective than S-LA. Thus, these findings will provide basic data for the potential development of α-lipoic acid as a chiral dietary additive for laying hens.

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Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period

Cited by 11 publications

References 51 publications

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Lipoamide Alleviates Oxidized Fish Oil-Induced Host Inflammatory Response and Oxidative Damage in the Oviduct of Laying Hens

R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens

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