Protective Effect of Alpha-linolenic Acid on Gentamicin Induced Nephrotoxicity in Mice

Kaplan, Halil Mahir; İzol, Volkan; Aridogan, Ibrahim Atilla; Olgan, E.; Yegani, Arash Alizadeh; Pazarcı, Perçin; Şingirik, Ergin

doi:10.3923/ijp.2016.562.566

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…It is known that ALA has a protective effect on many systems in the body, especially the cardiovascular system (Kaplan et al., 2016). ALA realises this protective effect through different mechanisms, especially its anti‐inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

Kaplan

Kizilgok

et al. 2020

Andrologia

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Polyunsaturated fatty acids (PUFAs) consist of alpha-linolenic acid (ALA) (18:3, n-3) and linoleic acid (LA) (18:2, n-6) (Erdinest, Shmueli, Grossman, Ovadia, & Solomon, 2012). PUFAs are essential forms of fatty acids; thus, they cannot be produced by the human body and must be obtained as nutrients in the diet (Besler, 2006). ALA is a key molecule required for synthesis of arachidonic acid; it also serves as a precursor molecule for the formation of eiocosapentanoic acid (EPA) and docosahexaenoic acid (DHA) that have essential

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Section: Discussionmentioning

confidence: 99%

“…The protein levels in the homogenised tissue samples were determined using the Bradford method (Kaplan et al., 2016).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

Kaplan

Kizilgok

et al. 2020

Andrologia

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“…ALA could improve gentamicin‐induced nephrotoxicity in mice by reducing the expression of COX‐2 and iNOS (70 mg/kg). It could also improve gentamicin‐induced ototoxicity in mice by reducing the expression of PLA 2 , COX‐2, and iNOS (200 mg/kg) (Kaplan, Izol, Aridogan, Olgan, & Singirik, 2016; Kaplan, Şingirik, Erdoğan, & Doran, 2017). Moreover, ALA (0.014 g of the diet) could improve high fructose‐induced nonalcoholic steatohepatitis in mice by normalizing aminotransferase activity and reducing the expression of TNF‐α, IL‐1β, and IL‐6 (Jeyapal et al, 2018).…”

Section: Pharmacological Effectsmentioning

confidence: 99%

The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

Yuan

Xie

Huang

et al. 2021

Phytotherapy Research

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α‐linolenic acid (ALA, 18:3n‐3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA. Information on ALA was collected from the internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library, and Europe PMC using a combination of keywords including “pharmacology,” “metabolism,” “sources.” The following findings are mainly contained. (a) ALA can only be ingested from food and then converted into eicosapentaenoic acid and docosahexaenoic acid in the body. (b) This conversion process is relatively limited and affected by many factors such as dose, gender, and disease. (c) Pharmacological research shows that ALA has the anti‐metabolic syndrome, anticancer, antiinflammatory, anti‐oxidant, anti‐obesity, neuroprotection, and regulation of the intestinal flora properties. (d) There are the most studies that prove ALA has anti‐metabolic syndrome effects, including experimental studies and clinical trials. (e) The therapeutic effect of ALA will be affected by the dosage. In short, ALA is expected to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of ALA.

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“…The protection of renal function was accompanied by the preservation of renal parenchyma structures observed in the histopathological study, although the morphological protection was evidenced from the minimum D-005 dose (25 mg/kg). Nephrotoxic treatment with gentamicin has been shown to cause an increase in COX-2 in rats and mice, which can be reversed after administration of antiinflammatory agents such as hesperidin, alpha linolenic acid, and an extract of Hypericum perforatum [35][36][37] . Further studies will elucidate if the anti-inflammatory effect of D-005, histopathologically proven in this study by decreasing the infiltration of inflammatory cells in the renal parenchyma is associated, at least partially, to its dual inhibitory capacity on 5-LOX and COX-2 enzymes, similar to flavocoxid 16,38 .…”

Section: Discussionmentioning

confidence: 99%

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

et al. 2022

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Introduction: Aminoglycoside-induced acute kidney injury (AKI) is a pathology closely linked to oxidative and inflammatory reactions. Taking into account the previous reported antioxidant and anti-inflammatory effects of D-005, a lipid extract obtained from Cuban palm Acrocomia crispa (Arecaceae) fruits, this work aimed to evaluate the effects of D-005 on kanamycin-induced AKI. Methods: Male Wistar rats were divided into 7 groups: negative control (vehicle, Tween 65/H2O) and six groups treated with kanamycin to induce AKI: positive control (vehicle), D-005 (25, 100, 200, and 400 mg/kg) and grape seed extract (GSE, 200 mg/kg). D-005, vehicle, and GSE oral treatments were administered once daily for seven days, 1 h before kanamycin (500 mg/kg, i.p.). Serum uric acid and urea concentrations, renal histopathology, and oxidative markers (malondialdehyde (MDA), sulfhydryl (SH) groups, and catalase (CAT) activity) were assessed. Results: D-005 significantly reduced uric acid and urea levels, starting from D-005 100 mg/kg. Histopathologically, D-005, at all the tested doses, protected renal parenchyma structures (glomeruli, proximal tubules, and interstitium). These findings were accompanied by a significant reduction of MDA and SH group concentrations as well as restoration of CAT activity. The highest percentages of inhibition were obtained with the dose of 400 mg/kg. GSE, the reference substance, also prevented kanamycin-induced biochemical and histopathological changes, as well as reduced MDA and SH groups and restored CAT activity. Conclusion: The administration of repeated oral doses of D-005 significantly protected against kanamycin-induced AKI, which could be associated with the antioxidant and anti-inflammatory effects of this extract.

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Protective Effect of Alpha-linolenic Acid on Gentamicin Induced Nephrotoxicity in Mice

Cited by 7 publications

References 14 publications

Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

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