Protective effect of Actiniopteris radiata (Sw.) Link. against CCl4 induced oxidative stress in albino rats

Manubolu, Manjunath; Goodla, Lavanya; Ravilla, Sivajyothi; Jayakumar, Thanasekaran; Dutta, Paresh C.; Malmlöf, Kjell; Obulum, Vijayasarathi Reddy

doi:10.1016/j.jep.2014.03.040

Cited by 41 publications

(41 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings revealed the role of CCl 4 in inducing oxidative stress in the hepatic tissue. In addition, these results corroborate the observations of Manubolu et al [22] who explained that the activity of the antioxidant enzymes is decreased in tissues of CCl 4 -exposed rats. One probable mechanism for the decreased activities of SOD, CAT and GPx may resulted from generation of the active metabolite, trichloromethyl radical leading to oxidative stress in the tissues.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Anti-inflammatory and hepatoprotective potentials of the aerial parts of <i>Silene villosa</i> Caryophyllaceae methanol extract in rats

Yusufoğlu¹,

Soliman²,

Foudah³

et al. 2018

Trop. J. Pharm Res

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

“…Oxidative stress is reported to represent the main mechanism in the pathogenesis of CCl 4 -induced hepatotoxicity in experimental animals [22]. Oxidative stress induced by CCl 4 is largely attributed to its active metabolite, trichloromethyl radical that plays a key role in producing liver damage [23].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and hepatoprotective potentials of the aerial parts of <i>Silene villosa</i> Caryophyllaceae methanol extract in rats

Yusufoğlu¹,

Soliman²,

Foudah³

et al. 2018

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…Oxidative stress represents the main mechanism in the induction of liver damage by CCl 4 in experimental animals (Manubolu et al, ). Oxidative stress induced by CCl 4 is attributed to its active metabolite, trichloromethyl radical that plays an important role in producing hepatotoxicity (Stoyanovsky & Cederbaum, 1999).…”

Section: Resultsmentioning

confidence: 99%

“…Oxidative stress represents the main mechanism in the induction of liver damage by CCl 4 in experimental animals (Manubolu et al, 2014).…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Antioxidant and hepatoprotective potential ofPlantago majorgrowing in Egypt and its major phenylethanoid glycoside, acteoside

et al. 2018

View full text Add to dashboard Cite

The defatted aqueous methanolic extract of the air‐dried aerial parts of Plantago major, collected from Nile delta, Egypt, was evaluated for its antioxidant and hepatoprotective effects. The major phenolic constituent; acteoside was isolated. Meanwhile, P. major exhibited potent hepatoprotective effect as it inhibited the serum activity elevation of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma‐glutamyl transferase (GGT) enzymes and total and direct bilirubin. It increased the serum total protein and albumin and attenuated CCl4‐induced lipid peroxidation (LPO) and increased GSH in the liver homogenates. Liver histopathology supported the biochemical findings. Acteoside inhibited lipopolysaccharide induced production of nitric oxide in RAW264.7 macrophages (IC50, 75.0 μM) and scavenged both superoxide radical (IC50, 1.51 μM) and DPPH radical (IC50 of 11.27 µM). P. major showed significant DPPH scavenging activity in vitro (IC50, 7.32 μg/mL). It could be concluded that, P. major has potent antioxidant, anti‐inflammatory, and hepatoprotective activities. Practical applications Plantago major L. is an edible plant that is used as food, particularly at the end of spring, just before the harvest of common vegetables. The plant grows wildly at canal banks of the Nile delta in Egypt and represents a very cheap food for farmers when frequent vegetables are not available. The research showed that the defatted aqueous methanolic extract has potential antioxidant and hepatoprotective effects in rats. The effect was very similar to the commercially used drug silymarin; indicating that it could be used as very cheap healthy food, food supplement or neutraceutical preparation to provide liver support for patients suffering from hepatic dysfunction. The main constituent acteoside was isolated and exhibited potent antioxidant and anti‐inflammatory activities in vitro, besides being safe on primary rat hepatocytes. Therefore this project provides a very cheap hepatoprotective drug for liver support, and a source of safe antioxidant and anti‐inflammatory compound.

show abstract

“…The CCl 4 taken by experimental animals is a toxic substance causing an alteration in the metabolism of liver through oxidative damage which can lead to degeneration of fats, fibrosis, hepatocellular death and cancer [42,43]. These alterations lead to generation of free radicals which in turn bring about loss of antioxidant defense enzymes in the biological system.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of juice extract of mesocarp rind of Citrullus lanatus in carbon tetrachloride-induced oxidative stress in rats

Bamisaye¹,

Sulyman²,

Ajani³

et al. 2017

JCLM

View full text Add to dashboard Cite

Protective effect of Actiniopteris radiata (Sw.) Link. against CCl4 induced oxidative stress in albino rats

Cited by 41 publications

References 37 publications

Anti-inflammatory and hepatoprotective potentials of the aerial parts of <i>Silene villosa</i> Caryophyllaceae methanol extract in rats

Anti-inflammatory and hepatoprotective potentials of the aerial parts of <i>Silene villosa</i> Caryophyllaceae methanol extract in rats

Antioxidant and hepatoprotective potential ofPlantago majorgrowing in Egypt and its major phenylethanoid glycoside, acteoside

Protective effect of juice extract of mesocarp rind of Citrullus lanatus in carbon tetrachloride-induced oxidative stress in rats

Contact Info

Product

Resources

About