Protective Effect of Acteoside on Carbon Tetrachloride-Induced Hepatotoxicity

Lee, Kyung Jin; Woo, Eun‐Rhan; Choi, Chul Yung; Shin, Dong Weon; Lee, Dong Gun; You, Ho Jin; Jeong, Hye Gwang

doi:10.1016/j.lfs.2003.07.020

Cited by 133 publications

(96 citation statements)

References 35 publications

(73 reference statements)

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“…Liver intoxication has increased as a result of exposure to high levels of environmental toxins (Lee et al, 2004). Carbon tetrachloride (CCl 4 ) is a potent hepatotoxin producing centrilobular hepatic necrosis (Recknagel, 1983), developing liver and kidney damage, and finally can result in cancer (Recknagel, 1967;Masuda, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Singab

Ayoub

Ali

et al. 2010

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Singab

Ayoub

Ali

et al. 2010

Pharmaceutical Biology

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“…8) The ingredients associated with the pharmacological activities of Herba Cistanches are echinacoside and acteoside, which have significant vasorelaxant, neuroprotective, hepatoprotective effects. 4,[9][10][11] The levels of these two constituents are commonly used as quality control markers of Herba Cistanches.…”

mentioning

confidence: 99%

Identification of Cistanche Species by Chemical and Inter-simple Sequence Repeat Fingerprinting

Shi

Wang

et al. 2009

Biological & Pharmaceutical Bulletin

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“…This then readily interacts with molecular oxygen to form the trichloromethyl peroxy radical (CCl 3 OO-) (Williams and Burk, 1990). This also forms covalent bond with sulfhydryl group of several membrane molecules like glutathione, which is considered as the initial step in the chain of events leading to lipid peroxidation and hepatic tissue destruction (Lee et al, 2004). Both radicals are capable of binding to proteins or lipids or of abstracting a hydrogen atom from a unsaturated lipids, which initiate lipid peroxidation and liver damage and by play a significant role in the pathogenesis of diseases (Kaplowitz et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and free radical scavenging activities of Lagerstroemia speciosa Linn. leaf extract

Thambi¹,

Sabu²,

Chungath³

2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe present study deals with the amelioration by Lagerstroemia speciosa Linn. leaf extract against hepatotoxicity induced by carbon tetrachloride (CCl 4 ), which was evaluated in terms of serum marker enzymes like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, serum total bilirubin, total protein levels along with concomitant hepatic and antioxidants like superoxide dismutase, catalase, glutathione, glutathione peroxidase and lipid peroxidation enzymes were monitored. These biochemical parameters altered by the single dose level of CCl 4 (0.75 ml/kg body weight, i.p). Pre treatment with L. speciosa prior to the administration of CCl 4 , at the doses of 50 and 250 mg/kg. body weight/day, p.o. for 7 days, significantly restored all the serum and liver tissue parameters near to the normal levels, respectively. Silymarin was used as a reference standard, prior to the administration of CCl 4 to rats. These findings indicate the protective potential of L. speciosa against hepato toxicity which possibly involve mechanism related to its ability of selective inhibitors of (reactive oxygen species like antioxidants brought about significant inhibition of TBARS suggesting possible involvement of O 2 · -, HO 2 · , and ·OH. In conclusion, the amelioration may be attributed to the synergistic effects of its constituents rather than to any single factor as the leaves are rich in tannins, sterols, flavonoids, saponins etc.

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Protective Effect of Acteoside on Carbon Tetrachloride-Induced Hepatotoxicity

Cited by 133 publications

References 35 publications

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats

Identification of Cistanche Species by Chemical and Inter-simple Sequence Repeat Fingerprinting

Hepatoprotective and free radical scavenging activities of Lagerstroemia speciosa Linn. leaf extract

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