Protective Effect of a Potent Antioxidant, Pomegranate Juice, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Tuğcu, Volkan; Kemahlı, Eray; Özbek, Emin; Arinci, Yasar Volkan; Uhri, Mehmet; Ertürküner, Pelin; Metin, Gökhan; Seçkin, İsmail; Karaca, Çetin; Ipekoglu, Nursen A; Altuğ, Tuncay; Çekmen, Mustafa; Taşçı, Ali İhsan

doi:10.1089/end.2008.0357

Cited by 51 publications

(39 citation statements)

References 31 publications

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“…The protective role of nitric oxide (NO) in different models of renal failure has been documented [136], including glycerol-induced renal failure [137] and nephrolithiasis induced by ethylene glycol [138]. These studies have demonstrated that levels of NO are decreased in glycerol-induced renal failure and different agents have shown to produce renoprotection by increasing the NO production [120].…”

Section: Pomegranate (Punica Granatum L)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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Section: Pomegranate (Punica Granatum L)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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“…Pectinase hydrolyzes the -1,4-galacturonide bonds in pecti, improves the extraction and Wltration process, and prevents the formation of pectin gels. The extract was Wltered, pasteurized, concentrated, and stored at ¡18°C, as described previously [21,22]. Concentrated PE was diluted in water (20 mL concentrated extract/500 mL of distilled water).…”

Section: Drugsmentioning

confidence: 99%

“…Known as "the fruit of the dead" in ancient Greek mythology [18], pomegranates have been used to treat inXammatory disease for centuries, reportedly have cholesterol-lowering properties, and prevent atherogenesis and urolithiasis [19][20][21]. Pomegranate fruit is rich in polyphenol antioxidants, including tannins and anthocyanins [12,22].…”

Section: Introductionmentioning

confidence: 99%

Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract

Yazıcı

Meriç²,

Mıdı

et al. 2011

Eur Arch Otorhinolaryngol

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The aim of this study was to investigate the effectiveness of the oral administration of pomegranate extract (PE) as a protective agent against cisplatin-induced ototoxicity. The study included a prospective, controlled animal study Group 1 (n = 6), received no cisplatin or PE, and group 2 (n = 6) received cisplatin at 8 mg/kg/day for 3 consecutive days. Group 3 (n = 6) received not only cisplatin at 8 mg/kg/day for 3 consecutive days, but also received PE (100 μL/day) via gavage for 5 days prior to the cisplatin injection and for 3 days concomitantly with the cisplatin injections. To measure cisplatin ototoxic effects, "distortion product otoacoustic emissions" (DPOAE) were analyzed 3 days before and after the cisplatin injections. Histological changes in the cochleas were observed by light microscopy. Compared with group 3, the DPOAE amplitudes of group 2 decreased significantly. Among the groups, there was a statistically significant difference in basal and mid turn external ciliated cells (ECC) number, but there was no statistically significant difference in apical turn. Differences in stria vascularis (SV) changes were statistically significant between the groups, and the median score for SV injury was significantly greater in group 2 than in group 3. Differences in the median scores for SGC changes being significantly greater in group 2 than in group 3. In conclusion, these results indicated that oral administration of PE afforded statistically significant protection to the cochlea in rats from cisplatin toxicity, and thus, oral experimental dose of PE administration may have a protective effect against cisplatin ototoxicity in rats.

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“…Recent studies have demonstrated oxidant stress in experimental urolithiatic rats would promote the synthesis and release of NO and caused the elevation of MDA secondarily. Meanwhile, activated antioxidant system upregulated SOD activities to scavenge free radical in early stage, but in late stage excessive oxidative stress decreased antioxidant enzyme activities [7,43,44]. Therefore, NO, MDA and SOD as the good indicators are widely used to estimate oxidant-antioxidant status both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antiurolithic effect and the possible mechanisms of Desmodium styracifolium and Pyrrosiae petiolosa in rats

Duan

Zhang

et al. 2011

Urol Res

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Chinese herbs Desmodium styracifolium (Ds) and Pyrrosiae petiolosa (Pp) have been widely used to treat urolithiasis with few side effects in traditional Chinese medicine (TCM). In vitro crystallization study has confirmed their prophylaxis of Calcium oxalate (CaO( x )) stones formation. However, little is known on their possible mechanisms in vivo. In the present study, we proposed to systematically evaluate their antilithic effects and clarify the underlying mechanism of Ds and Pp using a rat nephrolithiasis model and administering the aqueous extracts. Adult male Wistar rats were fed with 5% ammonium oxalate (AmO( x )) forage to induce nephrolithiasis. After 1 week, the rats were randomly divided into eight groups, and given low, medium, and high dose of each herb treatments (275, 550 and 1,100 mg/kg for Ds and 150, 300 and 600 mg/kg for Pp) by gavage for 3 weeks. In contrast to urolithic rats, urinary oxalate significantly reduced, and urinary calcium increased in medium and high dose Ds groups. Few depositions were observed in kidney with slight dilation of tubules and inflammatory infiltration. Osteopontin (OPN), nitric oxide (NO), and malondialdehyde (MDA) levels significantly decreased, but Superoxide dismutase (SOD) activities were enhanced in kidneys. In high dose Pp group, crystals were found in the dilation of tubules with slight inflammatory infiltration. Partial serum and urinary variables returned to the normal range. In conclusion, medium and high dose Ds has beneficial effect in preventing CaO( x ) stone formation by rising urinary Citrate excretion, decreasing urinary calcium, diuresis, and antioxidative effects. Although high dose Pp has relatively weak prophylaxis, it indicates significant anti-inflammatory and antioxidant effects.

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Protective Effect of a Potent Antioxidant, Pomegranate Juice, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Abstract: This experiment shows the protective effect of PJ in the EG-induced crystal depositions in renal tubules.

Cited by 51 publications

References 31 publications

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Reduction of cisplatin ototoxicity in rats by oral administration of pomegranate extract

Evaluation of antiurolithic effect and the possible mechanisms of Desmodium styracifolium and Pyrrosiae petiolosa in rats

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