Protective effect of a polyphenolic rich extract from Magnolia officinalis bark on influenza virus-induced pneumonia in mice

Protective effects of Yinhuapinggan granule on mice with influenza viral pneumonia

“…In this study, immunohistochemical analysis showed that NF-κB p65 was activated after infection. Compare with normal control group, the expressions of NF-κB p65 in the IFV-infected group were markedly increased as reported in previous studies [33,57]. Treatment with YHPG (15 and 30 g/kg) after infection significantly decreased the expressions of NF-κB p65 in comparison to that observed in the IFV-infected group, suggesting that the protective effects of YHPG on IFV-infected mice were partly connected with the inhibition of the expressions of NF-κB p65.…”

“…The levels of IL-2, IL-6 and TNF-α in serum were determined by ELISA. The lung index and inhibition rate of lung index were used as an indicator of pneumonia [33], according to the following equation:…”

Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways

“…Magnolia officinalis as a traditional Chinese herb has long been used for the treatment of anxiety, cough, headache and allergic diseases (Chen et al, 2011;Matsuda et al, 2001;Wang et al, 1995;Wu et al, 2011), and also have been used in traditional Chinese medicine to treat a variety of mental disorders including depression (Maruyama et al, 1998;Nakazawa et al, 2003;Watanabe et al, 1983). Magnolol, a compound purified from Magnolia officinalis, is responsible for the plant's pharmacological activities.…”

Liu-He-Tang inhibited plaque formation by human respiratory syncytial virus infection in cell lines of the human respiratory tract

“…Both influenza virus and HRSV are negative ssRNA viruses that infect the airway. Besides, several ingredients and their constituents of LHT have been proven to be effective against various viruses (Baba and Shigeta, 1987;Hatano et al, 1988;Badam, 1997;De Clercq, 2000;Ng and Wang, 2001;Sasaki et al, 2002;Cinatl et al, 2003;Crance et al, 2003;Takei et al, 2005;Imanishi et al, 2006;Sawai et al, 2008;Kuo et al, 2009;Kwon et al, 2010;Wu et al, 2011). Therefore, we supposed that LHT might have the antiviral activity to support its clinical use against HRSV.…”

“…Nevertheless, LHT contains 13 ingredients (Table 1). Among them, extracts of Zingiber officinale, Chaenomeles sinensis and Magnolia officinalis possess anti-viral activity against influenza virus (Imanishi et al, 2006;Sawai et al, 2008;Wu et al, 2011). Both influenza virus and HRSV are negative ssRNA viruses that infect the airway.…”