Protective Effect and Mechanism of Traditional Chinese Medicine on Myocardial Ischemia Reperfusion Injury

Abstract

After acute myocardial infarction, early restoration of myocardial perfusion by thrombolysis or percutaneous coronary intervention is the most effective way to reduce the size of myocardial infarction and improve clinical outcomes. However, recovery of blood flow to the ischemic myocardium may cause ischemia-reperfusion (I/R) injury, a phenomenon that instead reduces the efficacy of myocardial reperfusion. Traditional Chinese medicine (TCM) has long been used for the treatment of cardiovascular diseases and has shown remarkable efficacy. Many studies have shown that some TCMs and their active components can exert protective effects against myocardial I/R injury through different mechanisms. This review summarized the protective mechanisms and current research advances of TCMs in myocardial I/R injury.

Advances in research on the protective mechanisms of traditional Chinese medicine (TCM) in myocardial ischaemia-reperfusion injury

“…Extract of Mollugo pentaphylla can effectively reduce the incidence of arrhythmia in rats, improve the activity of Ca 2+ -ATPase in myocardial tissue and maintain the levels at magnitudes comparable to those in sham-operated rats(Li et al. 2016 ), suggesting that Mollugo pentaphylla extract has a certain protective effect against Ca 2+ overload in MI/R injury.…”

“…The mitogen-activated protein kinase (MAPK) signalling pathway is an important pathway causing myocardial cell injury and apoptosis (Li et al. 2016 ). Two medicinal plants [ Diospyros kaki Thunb.…”

“… 2017 ) and some other studies have indicated that TCMs can effectively relieve abnormal myocardial perfusion by acting on multiple pathways (Li et al. 2016 ) and controlling risk factors for cardiovascular disease. Moreover, the side effects of medicinal plants are usually mild (Sedighi et al.…”

Puerarin from Pueraria lobate attenuates ischemia‐induced cardiac injuries and inflammation in vitro and in vivo: The key role of miR‐130a‐5p/HMGB2 pathway

“…In the recent years, emerging attention has been made to handle diseases including cardiovascular disorders using substances identified from natural products. As a treasury for discovering functional compounds with disease treating potentials, Traditional Chinese Medicine (TCM) is elicting increasing interests and attempts to find natural substances from TCM that can attenuate myocardial injuries via different mechanisms has been made in the last decade (Liu et al, 2022). Puerarin (Pue) is an isoflavone extracted from the root of Pueraria lobate and a major functional component of the "Gegen soup" formula (Meng et al, 2022).…”

Antioxidant Activity of Aqueous Extract of Leaves and Seeds of Datura metel (Solanaceae) in Frog’s Heart Failure Model

“…It has been shown that oxidative stress can be successfully induced by using hydrogen peroxide on cultured cells and in several animal models, particularly on the heart of amphibians [ 5 , 6 ]. An antioxidant can be defined as any substance capable, at a relatively low concentration, of competing with other oxidizable substrates and thus lowering or preventing the oxidation of these substrates [ 7 ]. Many studies have shown that plants have antioxidant properties largely due to their phenolic content [ 2 , 8 ].…”