Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5

Deng, Lili; Ma, M.; Li, Shuying; Zhou, Lin; Sun, Yinghao; Wang, Juan; Yang, Qiaoqiao; Xiao, Chunling

doi:10.1016/j.ecoenv.2022.114329

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Recently, Ju et al (2022) proved that baicalin controlled the TLR2/myeloid differentiation primary response gene 88 (MYD88)/NF-κB p65 signaling pathway to reduce oxidative stress and the inflammatory response in COPD rats. Through regulating oropharyngeal microbiota and influencing the expression of the High Mobility Group Protein 1 (HMGB1)/ Caspase1 pathway, baicalin may also mitigate mouse lung inflammatory injury caused by exposure to PM2.5 (Deng et al, 2022). Frontiers in Pharmacology frontiersin.org…”

Section: Copdmentioning

confidence: 99%

Pharmacological effects of baicalin in lung diseases

Wang

2023

Front. Pharmacol.

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The flavonoids baicalin and baicalein were discovered in the root of Scutellaria baicalensis Georgi and are primarily used in traditional Chinese medicine, herbal supplements and healthcare. Recently, accumulated investigations have demonstrated the therapeutic benefits of baicalin in treating various lung diseases due to its antioxidant, anti-inflammatory, immunomodulatory, antiapoptotic, anticancer, and antiviral effects. In this review, the PubMed database and ClinicalTrials website were searched with the search string “baicalin” and “lung” for articles published between September 1970 and March 2023. We summarized the therapeutic role that baicalin plays in a variety of lung diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, pulmonary hypertension, pulmonary infections, acute lung injury/acute respiratory distress syndrome, and lung cancer. We also discussed the underlying mechanisms of baicalin targeting in these lung diseases.

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Section: Copdmentioning

confidence: 99%

Pharmacological effects of baicalin in lung diseases

Wang

2023

Front. Pharmacol.

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“…As the main effective constituent, BA has been found to have therapeutic effects on cardiovascular, hepatobiliary, brain, nervous system, and intestinal diseases ( Jin et al, 2019 ; Song et al, 2020 ; Xin et al, 2020 ; Ganguly et al, 2022 ). BA has been extensively reported to treat respiratory diseases ( Deng et al, 2022 ; Ju et al, 2022 ; Li et al, 2022 ). However, the widespread use of BA is still a challenge due to its low solubility and poor bioavailability ( Haider et al, 2018 ; Pramual et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The protective effects of baicalin for respiratory diseases: an update and future perspectives

Song

Liu

et al. 2023

Front. Pharmacol.

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Background: Respiratory diseases are common and frequent diseases. Due to the high pathogenicity and side effects of respiratory diseases, the discovery of new strategies for drug treatment is a hot area of research. Scutellaria baicalensis Georgi (SBG) has been used as a medicinal herb in China for over 2000 years. Baicalin (BA) is a flavonoid active ingredient extracted from SBG that BA has been found to exert various pharmacological effects against respiratory diseases. However, there is no comprehensive review of the mechanism of the effects of BA in treating respiratory diseases. This review aims to summarize the current pharmacokinetics of BA, baicalin-loaded nano-delivery system, and its molecular mechanisms and therapeutical effects for treating respiratory diseases.Method: This review reviewed databases such as PubMed, NCBI, and Web of Science from their inception to 13 December 2022, in which literature was related to “baicalin”, “Scutellaria baicalensis Georgi”, “COVID-19”, “acute lung injury”, “pulmonary arterial hypertension”, “asthma”, “chronic obstructive pulmonary disease”, “pulmonary fibrosis”, “lung cancer”, “pharmacokinetics”, “liposomes”, “nano-emulsions”, “micelles”, “phospholipid complexes”, “solid dispersions”, “inclusion complexes”, and other terms.Result: The pharmacokinetics of BA involves mainly gastrointestinal hydrolysis, the enteroglycoside cycle, multiple metabolic pathways, and excretion in bile and urine. Due to the poor bioavailability and solubility of BA, liposomes, nano-emulsions, micelles, phospholipid complexes, solid dispersions, and inclusion complexes of BA have been developed to improve its bioavailability, lung targeting, and solubility. BA exerts potent effects mainly by mediating upstream oxidative stress, inflammation, apoptosis, and immune response pathways. It regulates are the NF-κB, PI3K/AKT, TGF-β/Smad, Nrf2/HO-1, and ERK/GSK3β pathways.Conclusion: This review presents comprehensive information on BA about pharmacokinetics, baicalin-loaded nano-delivery system, and its therapeutic effects and potential pharmacological mechanisms in respiratory diseases. The available studies suggest that BA has excellent possible treatment of respiratory diseases and is worthy of further investigation and development.

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