Pharmacological effects of baicalin in lung diseases

Abstract

The flavonoids baicalin and baicalein were discovered in the root of Scutellaria baicalensis Georgi and are primarily used in traditional Chinese medicine, herbal supplements and healthcare. Recently, accumulated investigations have demonstrated the therapeutic benefits of baicalin in treating various lung diseases due to its antioxidant, anti-inflammatory, immunomodulatory, antiapoptotic, anticancer, and antiviral effects. In this review, the PubMed database and ClinicalTrials website were searched with the search string “baicalin” and “lung” for articles published between September 1970 and March 2023. We summarized the therapeutic role that baicalin plays in a variety of lung diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, pulmonary hypertension, pulmonary infections, acute lung injury/acute respiratory distress syndrome, and lung cancer. We also discussed the underlying mechanisms of baicalin targeting in these lung diseases.

The emerging role of lncRNAs in osteoarthritis development and potential therapy

“…It is known that circRNAs form a covalently closed loop and regulate gene expression, leading to governing cellular processes. Accumulating evidence has suggested that circRNAs play a critical role in osteoarthritis initiation and progression (Wu and Zou, 2021;Wang et al, 2023;Li and Lu, 2023;Xue et al, 2023).…”

“…LncRNA SNHG1 also alleviated the expression of MMPs, aggrecan, collagen, and ADAMTs in chondrocytes (Lei et al, 2019). Wang et al reported that lncRNA SNHG1 reduced cell apoptosis and inflammation via influencing the miR-195/IKK-α axis in chondrocyte (Wang et al, 2023). LncRNA SNHG5 increased proliferation of chondrocyte via targeting miR-26a/SOX2 axis in OA (Shen et al, 2018).…”

“…LncRNA WDR11-AS1 can bind to RNA-binding protein PABPC1 and then increase the SOX9 stabilization, resulting in facilitating extracellular matrix synthesis in osteoarthritis (Huang et al, 2023). LncRNA NAV2-AS5 alleviated chondrocyte inflammation via inhibition of miR-8082 and upregulation of TNFAIP3 interacting protein 2 (TNIP2) in osteoarthritis (Wang et al, 2023). LncRNA TM1-3P affected miR-144-3p and ONECUT2 and influenced apoptosis, inflammation, and proliferation of fibroblasts in osteoarthritis (Yi et al, 2022).…”

“…Baicalin, a flavonoid isolated from the roots of Scutellaria baicalensis Georgi (Lamiaceae), has been primarily used in traditional Chinese Medicine ( Srinivas, 2010 ). Baicalin has been reported to treat different diseases via exerting its various functions, such as anticancer, antioxidant, antiviral, anti-inflammatory effects ( Li et al, 2021 ; Ganguly et al, 2022 ; Song et al, 2023 ; Wang and Li, 2023 ). Baicalin has shown its protective functions in OA pathological process.…”

Hyaluronic Acid-Mediated Phenolic Compound Nanodelivery for Cancer Therapy

“…Through this expedient, the easy break of the DA disulfide bonds may be obtained in the TME, where GSH is present at high concentrations, thereby leading to the specific release of the loaded bioactive compounds. Finally, the co-delivered baicalein seems a highly appropriate choice, this bioactive natural compound produced by the plant Scutellaria baicalensis Georgi has been demonstrated to exert multiple beneficial effects in treating a variety of lung diseases, including lung cancer [ 141 ].…”