Protective effect against gastric mucosa injury of a sulfated agaran from Acanthophora spicifera

Júnior, Lindauro C. Pereira; Nascimento, Fernando G.; Oliveira, Samara Rodrigues Bonfim Damasceno; Lima, Glauber Cruz; Chagas, Francisco D.S.; Sombra, Venícios Gonçalves; Feitosa, Judith P.A.; Soriano, Eliane Marinho; Souza, Marcellus H.; Zocolo, Guilherme Julião; Silva, Lorena; Paula, Regina C.M. de; Damasceno, Renan Oliveira Silva; Freitas, Ana Lúcia Ponte

doi:10.1016/j.carbpol.2021.117829

Cited by 13 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 7 days of adaptive feeding, the rats were placed in metabolic cages and randomly divided into the following six groups: the natural control group (normal saline, NC), the model (M) group, the BZ group (10 g•kg −1 ), the ZS group, the fried BZ group (FBZ), and the ZSZBZ group. [1,18] Based on the results of the previous pretest, the rats were gavaged at a dose of 10 g•kg −1 per day for 7 consecutive days. [19] On the 7th day, the rats were given water only for 12 hours before gavage.…”

Section: Modeling and Drug Deliverymentioning

confidence: 99%

Anti-acute gastric ulcer resistance of Aurantii Fructus Immaturus juice processing Atractylodis Macrocephalae Rhizoma by regulating PTGS2, MAPK1, and KDR targets based on metabolomics and integrated network pharmacology analysis

Xu,

Wu,

Yang

et al. 2024

Sci Tradit Chin Med

View full text Add to dashboard Cite

Background Currently, traditional methods of treating acute gastric ulcer (AGU) have many drawbacks, necessitating an alternative therapy with fewer adverse effects. Atractylodis Macrocephalae Rhizoma (BZ) is known for strengthening the spleen and harmonizing the stomach. BZ processed with Aurantii Fructus Immaturus juice (ZSZBZ), a classic decoction since the Han Dynasty, can enhance the efficacy of BZ. However, the key active components and targets of action of ZSZBZ remain undiscovered. Aim of the study This study aimed to investigate the bioactive chemical constituents of ZSZBZ against AGU and their possible mechanisms of action, elucidating the scientific content of ZSZBZ processing. Materials and methods Initially, we examined rat stomach histopathology and conducted ELISA for oxidative stress and inflammation. Subsequently, we investigated underlying mechanisms using metabolomics. Further analysis of potent components and key targets in ZSZBZ was conducted through liquid chromatography-mass spectrometry analysis combined with network pharmacology. Finally, key targets were analyzed by Western blot. Results ZSZBZ improved gastric histopathology, reversing high alcohol-induced oxidative stress (SOD, CAT) and inflammatory level (TNF-α, IL-6) disorders. This is associated with ZSZBZ’s regulation of amino acid metabolism, energy metabolism, and inflammatory response-related metabolic pathways, along with key targets PTGS2, MAPK1, and KDR. The significant increase in potency of ZSZBZ may be attributed to elevated levels of naringenin, hesperidin, hesperidin, and rhamnoceroside after concoction. Conclusions Combining metabolomics and network pharmacology, this study elucidated that ZSZBZ enhanced gastroprotection by modulating amino acid metabolism, antioxidant, and inflammation-related targets and pathways, providing insights into the bioactive compounds and potential mechanisms of herbal concoctions.

show abstract

Section: Modeling and Drug Deliverymentioning

confidence: 99%

Anti-acute gastric ulcer resistance of Aurantii Fructus Immaturus juice processing Atractylodis Macrocephalae Rhizoma by regulating PTGS2, MAPK1, and KDR targets based on metabolomics and integrated network pharmacology analysis

Xu,

Wu,

Yang

et al. 2024

Sci Tradit Chin Med

View full text Add to dashboard Cite

show abstract

“…After 1 h, the rats were anesthetized with sodium pentobarbital, and the heart was sacrificed. The gastric tissue was taken and weighed (12)(13)(14).…”

Section: Gastric Mucosal Injury Caused By Ethanolmentioning

confidence: 99%

Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury

et al. 2021

View full text Add to dashboard Cite

In this study, deer suet fat was used as a raw material to study the effects of aqueous enzymatic extraction of deer oil on its components, followed by studies into the potential protective activity, and related molecular mechanisms of deer oil on ethanol-induced acute gastric mucosal injury in rats. The results show that aqueous enzymatic extraction of deer oil not only has a high extraction yield and has a small effect on the content of active ingredients. Deer oil can reduce total stomach injury. Without affecting the blood lipid level, it can reduce the oxidative stress, which is manifested by reducing the content of myeloperoxidase (MPO) and enhancing the activity level of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). It also enhances the expression of defense factors prostaglandin (E2), epidermal growth factor (EGF), and somatostatin (SS), it inhibits apoptosis evidenced by the enhanced of Bcl-2 and decreased expression of cleavage of caspase-3 and Bax. At the same time, it reduces inflammation, which is manifested by reducing the expression of IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) gastric tissue pro-inflammatory cytokines, and enhancing the expression of anti-inflammatory factors IL-4 and IL-10, and inhibiting the mitogen-activated protein kinase/nuclear factor kappa B (MAPK/NF-κB) signaling pathway in gastric tissue.

show abstract

“…Gastric mucosa injury is a common pathological state of multifactorial gastrointestinal disease worldwide, affecting the quality of life of millions of patients ( Pereira Junior et al, 2021 ). According to the survey, 20–60 people out of every 100 000 population suffer from gastric mucosa injury, accounting for 5%−10% of the world’s mortality ( Kim et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Protective role of fruits of Rosa odorata var. gigantea against WIRS-induced gastric mucosal injury in rats by modulating pathway related to inflammation, oxidative stress and apoptosis

Liu,

Yuan,

Luo

et al. 2024

Chinese Herbal Medicines

View full text Add to dashboard Cite

Protective effect against gastric mucosa injury of a sulfated agaran from Acanthophora spicifera

Cited by 13 publications

References 52 publications

Anti-acute gastric ulcer resistance of Aurantii Fructus Immaturus juice processing Atractylodis Macrocephalae Rhizoma by regulating PTGS2, MAPK1, and KDR targets based on metabolomics and integrated network pharmacology analysis

Anti-acute gastric ulcer resistance of Aurantii Fructus Immaturus juice processing Atractylodis Macrocephalae Rhizoma by regulating PTGS2, MAPK1, and KDR targets based on metabolomics and integrated network pharmacology analysis

Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury

Protective role of fruits of Rosa odorata var. gigantea against WIRS-induced gastric mucosal injury in rats by modulating pathway related to inflammation, oxidative stress and apoptosis

Contact Info

Product

Resources

About