Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from<i>Polygonum cuspidatum</i>in PC12 Cells

Objective. To evaluate the effect of an experimental gel containing Euclea natalensis extract on dentin permeability. Methods. Thirty-six dentin discs, 1-mm-thick. The discs were prepared from the coronal dentin of extracted human third molars that were divided into 3 groups (n = 10). The dentin discs in each group were treated with the groups following experimental materials: (FG): 1.23% fluoride gel, pH 4.1; (EG): Euclea natalensis extract gel, pH 4.1; (CG): control gel, pH 4.1. The gels were applied to the occlusal slide of the dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. The hydraulic conductance (HC) of each condition was determined four times using a fluid flow apparatus (Flodec). The data were analyzed using Two-way ANOVA and Tukey's test (P < 0.05). Results. The greatest mean reduction in HC was produced in group EG dentin discs (61.2%; P < 0.05). Even after acid challenge with 6% citric acid the great reduction occurred in group EG (66.0%; P < 0.05) than other groups (CG-77.1%, FG-90.8%). Conclusion. E. natalensis gel not only reduced dentin permeability, but also resisted posttreatment citric acid challenge without changing its permeability. Further research has to confirm this promising result in the clinical situation.

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“…This compound may act as a potent antioxidant which significantly interferes with the apoptotic event [33]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of an Experimental Gel ContainingEuclea natalensis: AnIn VitroStudy

Sales-Peres

Brianezzi

Marsicano

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…In Korea, people maintain oral health by using Polygonum cuspidatum (Polygonaceae) because of its efect in reducing oral microorganisms; Koreans also use P. cuspidatum in the treatment of arthritis and urinary diseases [37]. P. cuspidatum extract contains alkaloids, phenolics, and sterol/terpenes and induces biological activities such as anti-inlammation, antioxidation, and anticancer efects [38].…”

Section: Reactive Oxygen Species (Ros) and Lung Cancer Therapymentioning

confidence: 99%

Antitumor Effect of Natural Product Molecules against Lung Cancer

Zhong¹,

Qin²,

Chen³

et al. 2017

A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer

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Lung cancer treatment remains diicult because of multidrug resistance and adverse efects, and natural product molecules show powerful activity in lung cancer with few side efects. The molecular targets and eicacy of natural product molecules remain unclear. We described the molecular regulation of natural product molecules with antitumor activities, the antilung cancer activities and the clinical trials for lung cancer treatment of natural product molecules. The results support the updated systemic information on the use of natural product molecules to prevent cancer progression and their constituents for lung cancer treatment.

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“…28,29 Euclea natalensis extract alone may be an alternative product to protect oral health and prevent dental caries, 13 tooth wear and dentinal sensitivity. 31 For this reason, the effect of the chemical properties of Euclea natalensis as modifying factors for dental erosion should be explored in future investigations.…”

Section: Euclea Natalensismentioning

confidence: 99%

“…10 A study using histochemical analysis revealed the presence of naphthoquinones and polyphenols (such as flavonoids and tannins) in the root of the Euclea natalensis. 12,28,29 According to the literature presented, 28,29 the therapeutic effect of Euclea natalensis extract could be attributed to matrix metalloproteinases inhibition in the dentin. This may be justified, because the hardness analysis showed that there was a higher loss of hardness in the Euclea natalensis group, which, in turn, indicates the possibility of the collagen fiber structure having some flexibility.…”

mentioning

confidence: 99%

Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regions

et al. 2016

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Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regionsAbstract: This study evaluated the effect of Euclea natalensis gel on the reduction of erosive wear with or without abrasion, in enamel and dentin. During two five-day experimental crossover phases, volunteers (n = 10) wore palatal devices containing human enamel and dentin blocks (E = 8 and D = 8). The gel was applied in a thin layer in the experimental group, and was not applied in the control group. In the intraoral phase, volunteers used the palatal appliance for 12 h before the gel treatment, and were instructed to start the erosive challenges 6 h after the gel application. Erosion was performed with Coca-Cola ® (for 5 min) 4 times/day. The appliance was then put back into the mouth and was brushed after 30 minutes. After intraoral exposure, the appliances were removed and the specimens were analyzed using profilometry (mean ± SD, μm). The Euclea natalensis gel caused less wear in enamel in the experimental group (EROS = 12.86 ± 1.75 µm; EROS + ABRAS = 12.13 ± 2.12 µm) than in the control group (EROS = 14.12 ± 7.66 µm; EROS + ABRAS = 16.29 ± 10.72 µm); however, the groups did not differ from each other significantly. A statistically significant value was found for erosion and eros + abrasion in dentin (p = 0.001). Euclea natalensis may play a role in the prevention of dentin loss under mild erosive and abrasive conditions. A clinical trial is required to confirm these promising results in a clinical situation.

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Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone fromPolygonum cuspidatumin PC12 Cells

Cited by 34 publications

References 33 publications

Evaluation of an Experimental Gel ContainingEuclea natalensis: AnIn VitroStudy

Evaluation of an Experimental Gel ContainingEuclea natalensis: AnIn VitroStudy

Antitumor Effect of Natural Product Molecules against Lung Cancer

Erosion and abrasion-inhibiting in situ effect of the Euclea natalensis plant of African regions

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