Antitumor Effect of Natural Product Molecules against Lung Cancer

Zhong, Weilong; Qin, Yuan; Chen, Shuang; Sun, Tao

doi:10.5772/67241

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Fatigue and dyspnea were both improved due to the diet-only intervention, and dyspnea and PF improved due to the multicomponent intervention. Ginseng and feiji are not frequently documented, but some studies show that ginseng has a positive efect on fatigue [115,116] and feiji inhibits tumor progression and resolves phlegm, which improves breathing [117]. An improvement in fatigue often improves dyspnea [118], RF, and PF [119].…”

Section: Discussionmentioning

confidence: 99%

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Leyns,

Van Boterdael,

Baele

et al. 2024

European Journal of Cancer Care

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Objective. Lung cancer (LC) patients suffer from multiple cooccurring symptoms. Interventions that have the potential to impact more than one symptom within a symptom cluster should be identified. The aim of this review was to examine nonpharmacological interventions that were effective in the management of one or more of the following symptoms in LC patients: dyspnea, fatigue, physical functioning (PF), and role functioning (RF). Methods. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used for reporting this systematic review. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (using the PubMed interface), Embase (using the embase.com interface), and Web of Science were used as electronic databases. Randomized controlled studies were included if they assessed the effects of nonpharmacological interventions on dyspnea, fatigue, PF, and/or RF in patients with LC. Studies were evaluated with the Cochrane risk of bias tool, and relevant data were extracted and narratively summarized. Results and Conclusions. In total, 89 articles were included. Search results (until April 2023) show that most evidence was found for exercise interventions, followed by multicomponent, psychoeducational, diet, acupuncture, and other interventions. Studies that had an effect on multiple symptoms were observed to have the most frequent instances of positively affecting dyspnea, followed by PF, fatigue, and RF.

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Section: Discussionmentioning

confidence: 99%

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Leyns,

Van Boterdael,

Baele

et al. 2024

European Journal of Cancer Care

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“…The combination of phytocompounds or plant extracts with complementary therapy is highly appreciated and used for the treatment of cancer because it offers a novel approach that can enhance the efficacy of treatment and reduce toxicity while also potentially overcoming drug resistance. By harnessing the unique properties of natural compounds and their ability to augment the effects of chemotherapeutic drugs, it could become possible to improve outcomes for lung cancer patients and pave the way for more effective and personalized treatment approaches in the future [4,119].…”

Section: Synergistic Effects Of Combination Therapy (Natural Compound...mentioning

confidence: 99%

Exploring Synergistic Interactions between Natural Compounds and Conventional Chemotherapeutic Drugs in Preclinical Models of Lung Cancer

Boța,

Vlaia,

Jîjie

et al. 2024

Pharmaceuticals

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In the current work, the synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of current preclinical research findings. The prognosis for lung cancer patients is poor, with a 5-year survival rate of 18.1%. The use of natural compounds in combination with conventional chemotherapeutic drugs has gained significant attention as a potential novel approach in the treatment of lung cancer. The present work highlights the importance of finding more effective therapies to increase survival rates. Chemotherapy is a primary treatment option for lung cancer but it has limitations such as reduced effectiveness because cancer cells become resistant. Natural compounds isolated from medicinal plants have shown promising anticancer or chemopreventive properties and their synergistic effect has been observed when combined with conventional therapies. The combined use of an anti-cancer drug and a natural compound exhibits synergistic effects, enhancing overall therapeutic actions against cancer cells. In conclusion, this work provides an overview of the latest preclinical research on medicinal plants and plant-derived compounds as alternative or complementary treatment options for lung cancer chemotherapy and discusses the potential of natural compounds in treating lung cancer with minimal side effects.

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“…Curcumin and ginger also show anti-tumorigenic effects through disruption of the cell cycle and induction of apoptosis (8,9). In many cases, one of the major pathways involved in lung cancer, including AKT, NF-kB, MAPK, and STAT3, can be controlled by natural compounds with anti-tumorigenic effects (10).…”

mentioning

confidence: 99%