Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro

Chang, Xiayun; Luo, Fen; Jiang, Wenkai; Zhu, Lingpeng; Gao, Jin; He, He; Wei, Tingting; Gong, Shilin; Yan, Tianhua

doi:10.1016/j.intimp.2015.07.031

Cited by 123 publications

(69 citation statements)

References 41 publications

(47 reference statements)

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“…In accordance with previous study, IкBα degradation, NF‐κBp65 subunit upregulation in nuclear and immunofluorescence staining evidenced the translocation of NF‐κBp65 from cytoplasm to nuclear followed by the overexpression of RIP140 . After that, NF‐κBp65 binds to proinflammatory cytokines promoters to mediate the generations of TNF‐α, IL‐1β and IL‐6 . In this study, the phosphorylation of NF‐κBp65 and IкBα were elevated in AA rats , while sinomenine can downregulate the levels of p‐NF‐κBp65 and p‐IкBα in dose dependant manners, with NF‐κBp65 and IкBα as internal controls respectively.…”

Section: Discussionsupporting

confidence: 91%

Role of Sinomenine on Complete Freund's Adjuvant‐Induced Arthritis in Rats

et al. 2016

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The investigation was undertaken to evaluate the effect of sinomenine (Sin) on experimental adjuvant arthritis rats stimulated by Freund's complete adjuvant and explore the corresponding potential molecular mechanism. The content of proinflammatory cytokines such as tumor necrosis factoralpha, interleukin-1 beta and interleukin-6 were detected. Besides, canonical nuclear factor kappa B (NF-jB) pathway was also assessed to evaluate the antiarthritic potential of sinomenine. Pathological sections of rat paws showed sinomenine and diclofenac sodium significantly alleviated articular cartilage lesion, cellular infiltration, epithelial cell degeneration, synovial tissue vasodilation and congestion. The phosphorylations of inhibitor of kappaB alpha and NF-jB subunit p65 were downregulated with the treatment of sinomenine in dose dependent manners, as well as proinflammatory cytokines. Therefore, it was assumed that sinomenine might be a new therapeutic candidate to treat arthritis. V C 2016 IUBMB Life, 68(6): [429][430][431][432][433][434][435] 2016

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Section: Discussionsupporting

confidence: 91%

Role of Sinomenine on Complete Freund's Adjuvant‐Induced Arthritis in Rats

et al. 2016

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“…In addition, the protective effect of 123 on ethanol-induced acute gastric ulcer and H 2 O 2 -induced gastric epithelial cell damage were investigated. Intragastrical treatment with 123 inhibited the overproduction of pro-inflammatory cytokines (interleukin-6, interleukin-1β and tumor necrosis factor-α), enhanced antioxidant activity and alleviated acute gastric ulcer as well as gastric epithelial cell damage through the MAPK/NF-κB pathway [88].…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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“…In vivo, SDS could protect against acetaminophen-induced toxicity in C57BL/6 mice [17]. Recently Chang et al reported SDS could alleviate ethanol-induced acute gastric ulcer and H2O2-induced gastric epithelial cell damage through the MAPK/NF-κB pathway [18]. Several literatures reported that SDS regulated cytokine responses via NF-κB and ERK activation in LPS-stimulated RAW 264.7 macrophages in vitro and mice challenged with LPS in vivo [19,20].…”

Section: Introductionmentioning

confidence: 99%

Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking Induced Liver Injury

Sun¹,

Shen²,

Jiang³

et al. 2016

Preprint

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Abstract:The current study was designed to investigate the anti-inflammatory effect of salidroside (SDS) and the underlying mechanism by using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro and a mouse model of binge drinking induced liver injury in vivo. SDS downregulated protein expression of toll-like receptor 4 (TLR4) and CD14. SDS inhibited LPStriggered phosphorylation of LPS-activated kinase 1 (TAK1), p38, c-Jun terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). Degradation of IκB-α and nuclear translocation of nuclear factor (NF)-κB were effectively blocked by SDS. SDS concentration-dependently suppressed LPS mediated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels, as well as their downstream products, NO. SDS significantly inhibited protein secretion of interleukin (IL)-1β. Additionally C57BL/6 mice were orally administrated SDS for continuous 5 days, followed by three gavages of ethanol every 30 min. Alcohol binge drinking caused the increasing of hepatic lipid accumulation and serum transaminases levels. SDS pretreatment significantly alleviated liver inflammatory changes and serum transaminases levels. Further investigation indicated that SDS markedly decreased protein level of IL-1β in serum. Taken together, these data implied that SDS inhibits liver inflammation both in vitro and in vivo, and may be a promising candidate for the treatment of inflammatory liver injury.

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Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro

Cited by 123 publications

References 41 publications

Role of Sinomenine on Complete Freund's Adjuvant‐Induced Arthritis in Rats

Role of Sinomenine on Complete Freund's Adjuvant‐Induced Arthritis in Rats

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking Induced Liver Injury

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