Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells

Jacociunas, Laura Vicedo; Andrade, Heloı́sa Helena Rodrigues de; Lehmann, Maurı́cio; Pedersini, Larissa Wölfle; Ferraz, Alexandre de Barros Falcão; Silva, Juliana da; Dihl, Rafael Rodrigues

doi:10.1016/j.phymed.2013.06.003

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…Recent studies investigated genotoxicity of ALE. Both genotoxic and antigenotoxic effects were observed depending on the concentrations investigated, where high doses of ALE (5 mg/mL and 2 g/kg in cell line and mice studies, respectively) showed mutagenic effects, while lower doses showed protective antioxidant effects .…”

Section: Oxidative Stress Status After a 3‐wk‐treatment Period With Cmentioning

confidence: 99%

Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin‐induced diabetic rat

Magielse

Verlaet

Breynaert

et al. 2013

Molecular Nutrition Food Res

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The in vivo antioxidant activity of a quantified leaf extract of Cynara scolymus (artichoke) was studied. The aqueous artichoke leaf extract (ALE), containing 1.5% caffeoylquinic acid with chlorogenic acid being most abundant (0.30%), and luteolin-7-O-glucoside as major flavonoid (0.15%), was investigated by evaluating the effect on different oxidative stress biomarkers, after 3 wk oral supplementation in the streptozotocin-induced diabetic rat model. Apart from two test groups (0.2 g ALE/kg BW/day and 1 g ALE/kg BW/day, where BW is body weight), a healthy control group, untreated oxidative stress group, and vitamin E treated group (positive control) were included. A 0.2 g/kg BW/day of ALE decreased oxidative stress: malondialdehyde and 8-hydroxydeoxyguanosine levels significantly diminished, whereas erythrocyte glutathione levels significantly increased. A 1.0 g/kg BW/day ALE did not show higher antioxidant activity.

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Section: Oxidative Stress Status After a 3‐wk‐treatment Period With Cmentioning

confidence: 99%

Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin‐induced diabetic rat

Magielse

Verlaet

Breynaert

et al. 2013

Molecular Nutrition Food Res

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show abstract

“…Skarpanska et al [37] demonstrated that consuming artichoke leaf extract, a natural vegetable preparation of high antioxidant potential resulted in higher plasma total antioxidant capacity than placebo; however, it did not limit the oxidative damage to erythrocytes in athletes subjected to strenuous training. Jacociunas et al [38] documented the modulatory effect of C. scolymus on mutagenicity due to the presence of its constitutive antioxidant compounds.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

The Phytochemical Ingredients and Therapeutic Potential of Cynara scolymus L.

Sharma

Verma

Pankaj

et al. 2021

PBR

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Background: Medicinal herbs remain a vital source of new chemical entities, instead of the attempt of pharmaceutical companies using combinatorial and synthetic chemistry techniques for developing new drugs. Objectives: The primary aim of review is to highlight the different phytochemcial ingredients and their therapeutic potential in Cynara scolymus Methods: Cynara scolymus, commonly known as artichoke is a rich source of polyphenolic compounds, mainly caffeoylquinic acids and flavonoids, isolated in the polar extracts of the plant, together with the polysaccharide inulin. The worldwide scientific databases were comprehensively and systematically reviewed and summarized. Results: The beneficial effects of artichoke in experimental studies include antidiabetic, anti-obesity, anti-inflammatory, anti-hypercholesterolemic, hepatoprotective, nephroprotective, gastrointestinal protectant, reproductive, and anticancer properties. Studies with artichoke conducted in experimental animals reported no mortality or significant toxicity. Increasing attention is being paid to developing herbal medicines as a newly emerging treatment for the welfare of the patients in the last few decades. Conclusion: The present review detailed the versatile therapeutic efficiency and diverse application of C. scolymus. This medicinal herb has been appropriately used in conventional medicine for a long and helps cure various ailments.

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“…The population prevalence of chronic kidney disease exceeds 10%, and is more than 50% in high-risk subpopulations. Risk of kidney disease has a notable genetic component (Eckardt et al, 2013) Artichoke has been widely used in traditional medicine as a herbal medicament for therapeutic purposes (Jacociunas et al, 2013). Cardoon (Cynara cardunculus L) is a native plant to the Iberian Peninsula and the European Atlantic coast and invasive in American environments (Rial et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of feeding artichoke and milk thistle on rats treated with CCl4 and glycerol/saline solution

Amin

Mosa

Nagib

et al. 2019

African Journal of Biological Sciences

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The present study was performed to examine the effect of an artichoke and milk thistle consumption on liver function, kidney function, and lipid profiles. The chemical constituents were determined for the tested dried artichoke and milk thistle. This search was carried out using 72 adult male white albino rats randomly classified into two main groups. The first main group (36 rats) fed on a basal diet containing 20%-40% artichoke and 20%-40% milk thistle (acute liver failure groups). The second main group (36 rats) fed on a basal diet containing 20%-40% artichoke and 20%-40% milk thistle (acute renal failure groups).Then, the main groups were divided into six subgroups for each (n = 6). Results revealed that all groups treated with CCl4 or glycerol/ saline solution and administrated with different levels of dried artichoke and milk thistle (20%-40%) had a significant decrease in their liver function, kidney function, total cholesterol, triglycerides, LDL-c and VLDL-c cholesterol compared with the positive control group. On the other hand, a significant increase in HDL-c was recorded in all groups administrated with dried artichoke and milk thistle (20%-40%) compared with the control positive group. The results indicated that the consumption of artichokes and milk thistle could help in reducing the symptoms of acute liver and renal failure.

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Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells

Cited by 13 publications

References 24 publications

Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin‐induced diabetic rat

Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin‐induced diabetic rat

The Phytochemical Ingredients and Therapeutic Potential of Cynara scolymus L.

Effect of feeding artichoke and milk thistle on rats treated with CCl4 and glycerol/saline solution

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