Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats

Abstract

The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this plant, more commonly known as rosemary, has attracted the interest of the scientific community due to its numerous pharmacological properties and their potential therapeutic applications. Here, we tested the preventive effects of eeRo against gastric ulcer induced by 70% ethanol in male Wistar rats. In addition, we aimed to clarify the mechanism involved in the preventive action of the eeRo in gastric ulcers. Based on the analysis of markers of oxidative damage and enzymatic antioxidant defense systems, the measurement of nitrite and nitrate levels and the assessment of the inflammatory response, the eeRo exhibited significant antioxidant, vasodilator and antiinflammatory properties.

Novel Approach for the Development of Functional Goat Milk-based Beverages Using Medicinal Plant Extracts in Combination with High Intensity Ultrasound Treatment

“…Rosemary extract was the richest source of RA (1898.4 mg/L), followed by the lemon balm>mint>sage>lavender extracts. Amaral et al (38) obtained 38.5 mg of RA per g of ethanolic extract, which is consistent with the results obtained in this study (38 mg/g). However, Kontogianni et al (28) quantified lower contents of RA in rosemary extract.…”

Anti-inflammatory and gastroprotective potential of leaf essential oil of Cinnamomum glanduliferum in ethanol-induced rat experimental gastritis

“…Ethanol is well known as a damaging agent to the stomach that acts by a direct necrotizing action, which in turn decreases bicarbonate secretion and mucus production. Thus, the ethanolinduced gastric damage may be related to the generation of reactive species, reduced cell proliferation, and an exacerbated inflammatory response (Amaral et al 2013).…”

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

“…9,12,13 It could be used fresh, dry or distilled to obtain the essential oil (EO). 8,14 Rosemary has been reported to be one of the aromatic plants having high antioxidant activity for their antioxidant potentials. 7,15 The antioxidant activity of the EO of Rosemary was linked to its main components 16 which vary with seasonal variations.…”