Protective Action of Deglycyrrhizinized Liquorice on the Occurrence of Stomach Ulcers in Pylorus-Ligated Rats

Deglycyrrhizinised Liquorice

“…Glycyrrhizinic acid-reduced liquorice injected intraperitoneally or into the abdominal cavity reduced the frequency of stomach ulcer formation in pylorus-ligated rats (Aarsen, 1973;Andersson et al, 1971). Some protection was afford by doses of 25 mg or more when compared with a control group and complete protection was achieved with doses in excess of 75 mg.…”

“…Some protection was afford by doses of 25 mg or more when compared with a control group and complete protection was achieved with doses in excess of 75 mg. Although acid output was reduced by high doses (50 to 100 mg), protection against ulcer formation was also apparent at doses that caused little reduction (Andersson et al, 1971) or an increase in acid output (Aarsen, 1973). Stomach content was reduced to a similar extent by doses of 12.5 to 50 mg and to a greater extent by higher doses.…”