Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

Abstract

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation.

Impaired Regulation of Redox Transcriptome during the Differentiation of iPSCs into Induced Cardiomyocytes (iCMs)

“…Most of these antioxidants are endogenously regulated by NFE2L2/Nrf2, as described earlier. Here we are demonstrating the role of the genes that are involved in vitamin C antioxidant function (49). Endogenous activation and exogenous supplementation of Vitamin C scavenging ROS and reactive nitrogen species combines with Vitamin E and protects both hydrophobic compounds including membrane lipids (49).…”

“…Here we are demonstrating the role of the genes that are involved in vitamin C antioxidant function (49). Endogenous activation and exogenous supplementation of Vitamin C scavenging ROS and reactive nitrogen species combines with Vitamin E and protects both hydrophobic compounds including membrane lipids (49). During cardiomyocyte differentiation, about 65 genes were detected in antioxidant action of Vitamin C pathway, in which 21 genes were significantly up-regulated and 19 genes were down-regulated (Figure 5A-B).…”

Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice

“…Pineapple is a good source of antioxidants [ 47 ] . Antioxidant strength is measured by both phenolic and non-phenolic compounds, as they reverse free radical activities by decomposing peroxides and unpaired oxygen molecules, and adsorbing and neutralizing the free radicals to render them harmless to the body [ 48 ]. The fermentation process broke down undesirable compounds and increased the contents of some phenolic and non-phenolic compounds [ 49 , 50 ].…”

The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation

“…In the previous studies, CGA has been reported to prevent liver injuries induced by tetrachlorobenzoquinone, griseofulvin, ischemia/reperfusion, and lipopolysaccharide [14][15][16][17]. In addition, our previous study has showed that CGA prevented AP-induced liver injury in mice when it was orally given for consecutive 7 days before AP intoxication [18].…”