Protection tests on bronchial allergen challenge with disodium cromoglycate and thiazinamium

Exercise-Induced Bronchoconstriction in Patients with Bronchial Asthma. Its Prevention with an Antihistaminic Agent

“…[7] did not find pa tients developing EIB in either an increase of the histamine level in the blood or the increase of its metabolites in urine their re sults did not exclude the possibility that lo cally in the lung tissue the histamine level could have been increased. The results ob tained by Booij-Noord et al [2] point also to the histamine as a mediator of EIB. They have found that thiazinaminum pro tects against bronchospasm induced by inhalation of an allergen.…”

Sodium Cromoglycate (Cromolyn Sodium)

“…Similarly, Booij-Noord and associates (Booij-Noord et al, 1970a;Booij-Noord and de Vries, 1969; have shown that the inhalation of a 1 % aerosol solution for 3 minutes (Le. In 5 patients with asthma who gave immediate asthmatic reactions to extracts of grass pol1en or Dermatophagoides culinae, Pepys and associates found that an inhalation of 20 mg sodium cromoglycate (1 capsule) 10 to 12 minutes prior to antigen inhalation completely inhibited the fall in FEVl in 4 patients (and in fact increased the FEV 1 above the pre-test level in 3 cases) and provided partial inhibition in 1.…”

“…These workers also showed that whilst bronchial protection occurred when the same allergen was used sequentially, it did not occur when a different antigen was introduced after 5 hours. Similarly, Booij-Noord and associates (Booij-Noord et al, 1970a;Booij-Noord and de Vries, 1969; have shown that the inhalation of a 1 % aerosol solution for 3 minutes (Le. In contrast, 7 of 8 patients who received only the first antigen were protected at both 30 minutes and 5 hours after sodium cromoglycate.…”

Bronchial Provocation Tests

“…High levels of specific IgE have an effect comparable to that of high concentrations of antigens in producing late reactions. Late reactions are generally less reversible than are immediate ones and are inhibited by cromolyn sodium, corticosteroids, and corticosteroid aerosols [47,52] but not by f)-adrenergic agonists and antihistamines [53,54].…”