Exercise-Induced Bronchoconstriction in Patients with Bronchial Asthma. Its Prevention with an Antihistaminic Agent

Zieliński, J; Chodosowska, E

doi:10.1159/000193773

Cited by 23 publications

(4 citation statements)

References 7 publications

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“…However some beneficial effects have been reported: (1) Amitriptyline and ketotifen have been shown to be of some benefit in chronic asthma (Sugihara, Ishiara & Noguchi, 1965;Meares, Mills, Horvath, Atkinson, Pun & Rand, 1971;Gobel, 1978;Craps et al, 1978). (2) In antigen and exercise provocation tests, the bronchospasm following challenge may be reduced by antihistamines (Booij-Noord, Orie, Berg & de Vries, 1970;Girard & Cuevas, 1977;Zielinski & Chodosowska, 1977;Eiser, Guz, Mills & SnashalL 1979). (3) Antihistamines cause bronchodilatation in asymptomatic chronic asthmatics (Popa, 1977;Nogrady, Hartley, Handslip & Hurst, 1978).…”

Section: Discussionmentioning

confidence: 99%

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

Church

Gradidge

1980

British J Pharmacology

109

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A series of cationic, lipophilic histamine H1‐receptor antagonists, neuroleptics, antidepressants and monoamine oxidase inhibitors were tested for their effects on anti‐IgE‐induced histamine release from human lung fragments in vitro. They had a biphasic effect: at low concentrations a dose‐related inhibition of histamine release was observed whereas, at higher concentrations, the drugs liberated histamine even in the absence of antigen. Mepyramine, a much less lipophilic drug than the others tested, was only weakly active on mast cells at pharmacological concentrations. The potency of the drugs as release inhibitors was not related quantitatively to their histamine liberating potency. There was no correlation between activity on mast cells and histamine H1‐receptor antagonism. Mast cell stabilization may play a part in the activity of these drugs as Antiallergic agents.

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Section: Discussionmentioning

confidence: 99%

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

Church

Gradidge

1980

British J Pharmacology

109

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“…Leukotriene receptor antagonists have also been shown to be of some value in preventing EIA in children [99]. The data on ketotifen [100], calcium channel blockers [101][102][103], and antihistamines [104] in the treatment of EIA are conflicting.…”

Section: Treatment Of Exercise-induced Asthmamentioning

confidence: 99%

Asthma in Children and Adolescents: A Comprehensive Approach to Diagnosis and Management

Chang

2011

Clinic Rev Allerg Immunol

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Asthma is a chronic disease that has a significant impact on quality of life and is particularly important in children and adolescents, in part due to the higher incidence of allergies in children. The incidence of asthma has increased dramatically during this time period, with the highest increases in the urban areas of developed countries. It seems that the incidence in developing countries may follow this trend as well. While our knowledge of the pathophysiology of asthma and the available of newer, safer medication have both improved, the mortality of the disease has undergone an overall increase in the past 30 years. Asthma treatment goals in children include decreasing mortality and improving quality of life. Specific treatment goals include but are not limited to decreasing inflammation, improving lung function, decreasing clinical symptoms, reducing hospital stays and emergency department visits, reducing work or school absences, and reducing the need for rescue medications. Non-pharmacological management strategies include allergen avoidance, environmental evaluation for allergens and irritants, patient education, allergy testing, regular monitoring of lung function, and the use of asthma management plans, asthma control tests, peak flow meters, and asthma diaries. Achieving asthma treatment goals reduces direct and indirect costs of asthma and is economically cost-effective. Treatment in children presents unique challenges in diagnosis and management. Challenges in diagnosis include consideration of other diseases such as viral respiratory illnesses or vocal cord dysfunction. Challenges in management include evaluation of the child's ability to use inhalers and peak flow meters and the management of exercise-induced asthma.

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“…Antihistamines either delivered as aerosols (44), or by intramuscular injection (92), have been shown to be effective in the prevention of EIA, lending further support to the concept of ediator release in the pathogenesis of EIA.…”

Section: Drugs Whzch Preuent Eiamentioning

confidence: 77%

Current Concepts of Exercise‐Induced Asthma

Anderson

1983

Allergy

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Exercise-Induced Bronchoconstriction in Patients with Bronchial Asthma. Its Prevention with an Antihistaminic Agent

Cited by 23 publications

References 7 publications

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

Asthma in Children and Adolescents: A Comprehensive Approach to Diagnosis and Management

Current Concepts of Exercise‐Induced Asthma

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