Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns)

Choe, SeEun; Shin, Jihye; Kim, Ki-Sun; Song, Sok; Mi, Ra; Jung, Byung-Il; Hyun, Bang-Hun; Park, Bong‐Kyun; An, Dong-Jun

doi:10.3390/pathogens9080608

Cited by 6 publications

(9 citation statements)

References 21 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CSFV E rns and BVDV BE rns ELISAs used to detect specific antibodies were performed as described previously [ 3 , 4 ]. The VDPro ® CSF E rns Ab b-ELISA (MEDIAN Diagnostic Co., Cat No.…”

Section: Methodsmentioning

confidence: 99%

“…A study in which early, middle, and late pregnancy sows were challenged with virulent CSFV after inoculation with the Flc-LOM-BE rns vaccine showed that they were protected against vertical transmission of the viral infection to the fetus [ 3 ]. Lactogenic transfer of maternally derived antibodies from sows immunized with the Flc-LOM-BE rns vaccine provided piglets with passive protection from virulent CSFV until they acquired active immunity [ 4 ]. Currently, all pigs in mainland South Korea (excluding Jeju island) receive either a mixed LOM plus swine erysipelothrix rhusiopathiae (SE) vaccine (LOM + SE) or a mixed Flc-LOM-BE rns plus SE vaccine (Flc-LOM-BE rns + SE) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lactogenic transfer of maternally derived antibodies from sows immunized with the Flc-LOM-BE rns vaccine provided piglets with passive protection from virulent CSFV until they acquired active immunity [ 4 ]. Currently, all pigs in mainland South Korea (excluding Jeju island) receive either a mixed LOM plus swine erysipelothrix rhusiopathiae (SE) vaccine (LOM + SE) or a mixed Flc-LOM-BE rns plus SE vaccine (Flc-LOM-BE rns + SE) [ 4 , 5 ]. In the field, a single shot injection of a mixed Flc-LOM-BE rns + SE vaccine is gradually being replaced the mixed LOM + SE vaccine [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

et al. 2021

Self Cite

View full text Add to dashboard Cite

Herein, we compared the productivity of pigs inoculated with one of two classical swine fever (CSF) vaccines (low virulent of Miyagi (LOM) or Flc-LOM-BErns) plus the swine erysipelothrix rhusiopathiae (SE) vaccine. The feed intake and weight increase of the pigs inoculated with Flc-LOM-BErns + SE were normal. However, the feed intake of the pigs inoculated with LOM + SE dropped sharply from four days post-vaccination (dpv). In addition, the slaughter date was an average of eight days later than that of the pigs inoculated with Flc-LOM-BErns + SE. All pigs inoculated with the Flc-LOM-BErns + SE vaccine were completely differentiated at 14 days against CSF Erns antibody and at approximately 45 days against the bovine viral diarrhea virus (BVDV) Erns antibody; the titers were maintained until slaughter. Leucopenia occurred temporarily in the LOM + SE group, but not in the Flc-LOM-BErns + SE group. Expression of tumor necrosis factor (TNF)-α and IFN-γ was significantly (p < 0.05) higher in the LOM + SE group than in the mock (no vaccine) group. When conducting the same experiment on a breeding farm, the results were similar to those of the laboratory experiments. In conclusion, the biggest advantage of replacing the CSF LOM vaccine with the Flc-LOM-BErns vaccine is improved productivity.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…These regions were substituted with the full-length bovine viral diarrhea virus (BVDV) Erns gene sequence and the 3′ end (52 base pairs) of the BVDV capsid gene, yielding the Flc-LOM-BE rns vaccine [ 128 ]. According to recent studies, this novel chimeric vaccine has shown to provide complete protection in pregnant sows [ 128 , 135 ]. The use of Flc-LOM-BE rns in domestic pigs and bait vaccination of wild boar in South Korea has just started, hence the strength of the DIVA principle and the safety of this marker vaccine candidate is still unclear.…”

Section: Chimeric Pestivirusesmentioning

confidence: 99%

A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions

et al. 2021

View full text Add to dashboard Cite

Classical swine fever (CSF) is, without any doubt, one of the most devasting viral infectious diseases affecting the members of Suidae family, which causes a severe impact on the global economy. The reemergence of CSF virus (CSFV) in several countries in America, Asia, and sporadic outbreaks in Europe, sheds light about the serious concern that a potential global reemergence of this disease represents. The negative aspects related with the application of mass stamping out policies, including elevated costs and ethical issues, point out vaccination as the main control measure against future outbreaks. Hence, it is imperative for the scientific community to continue with the active investigations for more effective vaccines against CSFV. The current review pursues to gather all the available information about the vaccines in use or under developing stages against CSFV. From the perspective concerning the evolutionary viral process, this review also discusses the current problematic in CSF-endemic countries.

show abstract

“…Активувати механізм специфічного імунного захисту можливо шляхом імунізації тварин антигенами збудників інфекційних хвороб -вакцинацією (Riber et al, 2015;Langel et al, 2016). Слід зауважити, що один із найважливіших факторів у проведенні ефективної імунопрофілактики -це імунізація тварин з урахуванням рівня колостральних антитіл, специфічних до вакцинного антигену, оскільки високий рівень материнських антитіл може сприяти нейтралізації вакцинного антигену (Choe et al, 2020), що впливає на рівень імунної відповіді за введення вакцинного антигену, та, як наслідок, на захист тварин (Kielland et al, 2015;Chung et al,, 2020).…”

Section: вступunclassified

Colostral immunity of piglets to the Aujeszky disease virus in case of active immunization sows

Holda¹,

Масюк²,

Kokariev³

et al. 2020

Theor. Appl. Vet. Med.

View full text Add to dashboard Cite

The current question of today is the formation of effective immune protection in young pigs against infectious diseases, achieved by piglets vaccination in the first weeks of their life. It is known that one of the factors influencing the quality of vaccination is colostral antibodies, which are able to deactivate the vaccine antigen. Considering this, it is important to determine the duration of colostral immunity of piglets to antigens of the Aujeszky’s disease virus during active sows immunization. For this, was formed a group of sows of 2nd-3rd gestation periods with 25 animals in each. Sows were immunized parenterally against Aujeszky’s disease with the «Adivak» vaccine at a dose of 2 ml, by mass vaccination, three times per year. The level of specific antibodies to glycoproteins E (gE) and B (gB) was determined in the blood serum of piglets before sucking colostrum and every 7 days of life until 77 days from birth by enzyme-linked immunosorbent assay (ELISA). It was revealed that before consuming colostrum, piglets did not have specific antibodies to the antigens of the Aujeszky disease virus. From 7th till 70th days of life, all piglets had specific IgG to the antigens gB and gE of the Aujeszky disease virus, and by the seventy-seventh day, 29% of the animals were seronegative. Thus, newborn piglets before colostrum suckling do not have specific immune protection against the Aujeszky disease virus against the background of sow immunization. Consumption of colostrum by piglets promotes their formation of colostral immunity, specific to the antigens of the Aujeszky disease virus. The duration of colostral antibodies’ circulation specific to the antigens of the Aujeszky disease virus in the piglets peripheral blood is 70 days. On the seventy-seventh day from birth, the level of colostral immunoglobulins decreased sharply, which contributed to the appearance of seronegative animals and an increase in their sensitivity to the action of an epizootic strain of the virus.

show abstract

Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns)

Cited by 6 publications

References 21 publications

Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

A Critical Review about Different Vaccines against Classical Swine Fever Virus and Their Repercussions in Endemic Regions

Colostral immunity of piglets to the Aujeszky disease virus in case of active immunization sows

Contact Info

Product

Resources

About