Protection of Dietary Polyphenols against Oral Cancer

Yi, Ding; Yao, Hua; Yao, Yan‐an; Fai, Leonard Yenwong; Zhang, Zhuo

doi:10.3390/nu5062173

Cited by 48 publications

(35 citation statements)

References 72 publications

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“…Overcoming drug resistance by enhancing apoptosis of precursor and tumor cells is a key event for cancer prevention and therapy [22]. In this context, bioactive food components [23][24][25][26] have been demonstrated for induction of apoptosis and play an emerging role in cancer therapy. One mechanism is the activation of endogenous reactive oxygen species (ROS) [27,28] in OSCC [29][30][31][32][33], with subsequent apoptosis in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…As suggested for multi-step carcinogenesis [2] it remains unclear whether phytochemicals are standardized effective for chemoprevention [2,25,26,[39][40][41][42][43][44][45][46][47] in the treatment of precursor lesions or OSCC development, but they provide a clear rational for further studies in the carcinogenesis of OSCC [2,[41][42][43][44][45][46][47][48].…”

Section: Sin III Cismentioning

confidence: 99%

See 1 more Smart Citation

Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis

Grimm¹,

Cetindis²,

Lehmann³

et al. 2014

Acta Odontologica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Section: Sin III Cismentioning

confidence: 99%

Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis

Grimm¹,

Cetindis²,

Lehmann³

et al. 2014

Acta Odontologica Scandinavica

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“…These hot drinks are rich sources of polyphenols, especially epigallocatechin gallate (EGCG), gallocatechin (EGC), (−)-epicatechin gallae (ECG), (−)-catechin gallate (CG), (−)-epicatechin (EC), and (+)-catechin (C) [54]. These polyphenols seem to play an important role in the reduction of cell growth, induction of apoptosis, and inhibition of angiogenesis in oral cancer cell lines [55,56]. A main difference between the Prudent/healthy, the Mediterranean diet and the High Protein dietary pattern in this study is the fact that the latter included red meat.…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and the risk of oral, pharyngeal and laryngeal cancer in Syria: a case control study

et al. 2016

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Background: No study has investigated the relationship between dietary patterns and the risk of oral, pharyngeal and laryngeal cancer in the Middle East and North Africa region. Thus, the present study aimed to investigate the association between dietary patterns and the risk of oral, pharyngeal and laryngeal cancer in Syria. Methods: A hospital-based unmatched case-control study was conducted on 108 cases with histologically confirmed oral, pharyngeal or laryngeal squamous cell carcinoma and 105 healthy controls, who did not suffer from any dietrelated diseases. Dietary intake data were collected by a face-to-face interview, using a food frequency questionnaire. Socio-demographic and health risk behavioural information was collected using a self-completed questionnaire. Factor analysis and logistic and linear regression analyses were performed. The level of significance was set at 5 %. Results: The factor analysis revealed three dietary patterns labeled "Western", "Traditional Syrian" and "High Protein". The results of logistic regression analyses showed that consumption of Western food in the middle and high tertiles posed a significant increased oral, pharyngeal and laryngeal cancer risk of four and three-fold, respectively (adjusted OR = 4.05, 2.80; 95 % CI = 1.57-10.44, 1.05-7.51; P = 0.004, 0.041; respectively). In contrast, consumption of Traditional Syrian in the high tertile and High Protein in the middle and high tertiles displayed significant protective effects in relation to oral, pharyngeal and laryngeal cancer risk (adjusted OR = 0.28, 0.24, 0.10; 95 % CI = 0.10-0.80, 0.10-0.62, 0.03-0.25; P = 0.018, 0.003, <0.001; respectively). Compared to males, females were more likely to adhere to the High Protein dietary pattern. Traditional Syrian pattern's scores decreased with increasing level of education and smoking. High Protein pattern's scores decreased with age and smoking and increased with working status. Conclusions: Traditional Syrian and High Protein dietary patterns were associated with a decreased oral, pharyngeal and laryngeal cancer risk, whereas Western pattern was associated with an increased oral, pharyngeal and laryngeal cancer risk.

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“…Knowledge of polyphenol functions, bioavailability, metabolism, and significance to health has been frequently reviewed , as has their relation with apoptosis , inflammation , obesity , and the prevention of chronic disorders such as cardiovascular diseases , cancer , and diabetes . The effects of some polyphenols on angiogenesis have also been studied over the last years since angiogenesis is modified in several pathologies (cancer, diabetic retinopathy, chronic wounds, or stroke, etc.…”

Section: Introductionmentioning

confidence: 99%

New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols

Diniz

Suliburska

2017

Molecular Nutrition Food Res

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Polyphenols can be found in natural products of plant origin, including vegetables, fruits, and beverages. A large number of these plant origin compounds are an integral part of the human diet and in the past decade evidence has shown their beneficial properties in human health, by acting in several cell signaling pathways. Among other beneficial effects, polyphenols have been associated with angiogenesis. Increasing evidence highlighting the ability of dietary polyphenols to influence angiogenesis by interfering with multiple signaling pathways is debated. Particular emphasis is given to the mechanisms that ultimately may induce the formation of capillary-like structures (by increasing endothelial cell proliferation, migration, and invasion) or, conversely, may inhibit the steps of angiogenesis leading to the inhibition/regress of vascular development. Dietary polyphenols can, therefore, be viewed as promising nutraceuticals but important aspects have still to be further investigated, to deep knowledge concerning their concentration-mediated effects, effect of specific polyphenols, and respective metabolites, to ensure their appropriate and effective usefulness as proangiogenic or antiangiogenic nutraceuticals.

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Protection of Dietary Polyphenols against Oral Cancer

Cited by 48 publications

References 72 publications

Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis

Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis

Dietary patterns and the risk of oral, pharyngeal and laryngeal cancer in Syria: a case control study

New insights into the antiangiogenic and proangiogenic properties of dietary polyphenols

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