Protection of Dayak Onion Tuber Extract (Eleutherine Palmifolia) Against Kidney Histopathological Appearence of Albino Male Rat Strain Wistar which was Induced by Alloxan

Abstract

The purpose of this study was to know the effect of Dayak onion tuber extract (Eleutherine palmifolia) given by per oral in lowering levels of histophatology damage kidney of albino male rat (Rattus norvegicus) strain Wistar which was induced by alloxan. Animals which were used in this research were 24 white male rats (Rattus norvegicus) strain Wistar, and then divided into 6 groups. The negative control group K (-) were given with aquabidest and CMC-Na 1% during the therapy period, the positive control group K (+) were given with alloxan 110 mg / kgbw, the group of drug control K (O) were given with alloxan and oral therapy with metformin 9 mg / 200g bw / day, the treatment group 1 (P1) were given with alloxan and per oral therapy with extract of Dayak onion tuber 100 mg / kgbw, the treatment group 2 (P2) were given with alloxan and per oral therapy with extract of Dayak onion tuber 200 mg / kgbw and the treatment group 3 (P3) were given with alloxan and per oral therapy with extract of Dayak onion tuber 400 mg / kgbw. The therapy was given for 14 days, then the animals were sacrificed with ketamine and then its kidney was taken for examination of hisphatology in kidney. Observations based on their depiction of renal histopathology tubular degeneration and necrosis, glomerular necrosis, intestitial infiltration and glomerular sclerosis. Data obtained from the scoring of histopathological appearence albino rat kidneys were analyzed by test Kruskal-Wallis and if there is a real difference followed by Mann-Whitney test using SPSS 20.0 for windows. The results showed that the extract of Dayak onion tuber 400 mg/ kgbw can reduce the degree of kidney damage in albino male rat exposed to alloxan significantly. Key words: Eleutherine palmifolia, alloxan, kidney, histhopathology

Anti-diabetic properties of traditional herbal concoction containing Eleutherine palmifolia (L.) Merr., Momordica charantia L., and Syzygium polyanthum (Wight.): a bibliometric analysis

“…While, Ahmed et al (1998) found that a methanolic extract of E. palmifolia bulb reduced glucose tolerance in Swiss albino rats. Nurcahyawati et al (2017) also revealed that the bulb of E. palmifolia protected the kidneys of alloxan-induced Wistar rats. A dosage of 400 g/ kg of E. palmifolia bulb was evidenced to protect against kidney tubule degeneration, tubular and globular necrosis, and interstitial infiltration.…”

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application

“…The results showed a significant reduction using the reflux and maceration methods, with a percentage glucose level of 62.2% and 74.6% at 90 min posttreatment, respectively, in contrast to the positive controls, glibenclamide (55.17% ± 9.55). Meanwhile, Nurcahyawati et al [37] documented that the extract of the E. bulbosa bulb protected the kidney of alloxan-induced Wistar rats. A dose of 400 mg/kg of E. bulbosa bulb was sufficient to protect the degeneration of kidney tubule, tubular and globular necrosis, as well as interstitial infiltration compared to the positive control, metformin.…”