Protection of Cattle against Experimentally Induced Anaphylaxis

Aitken, Maureen M.; Sanford, J.

doi:10.1038/223314a0

Cited by 20 publications

(11 citation statements)

References 7 publications

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“…Experimentally induced systemic anaphylaxis in cattle and sheep is characterized by a fall in arterial blood pressure, increased resistance to pulmonary inflation and a marked pulmonary vasoconstriction (Aitken & Sanford, 1969b;Alexander et al, 1970). Isolated pulmonary artery vein strips taken from protein sensitized cattle react to specific antigen with a Schultz-Dale response (Eyre, 1970a).…”

Section: Discussionmentioning

confidence: 99%

“…The relative significance of these amines has not been determined, but it is well known that antihistamines are ineffective in treating naturally occurring allergic diseases of cattle. The antihistaminics and anti-5-HT agents do not efficiently protect cattle or sheep from experimentally induced systemic anaphylaxis (Alexander et al, 1970;Aitken & Sanford, 1969b), but the anti-5-HT agent methysergide partially antagonizes bovine passive cutaneous anaphylactic reactions (Eyre, 1970b). A tentative suggestion has been made that histamine may be comparatively less important than other mediators in anaphylaxis in ruminants (Alexander et al, 1970;Aitken & Sanford, 1969b).…”

Section: Introductionmentioning

confidence: 99%

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Release of dopamine from bovine lung by specific antigen and by compound 48/80

Eyre

Deline

1971

British J Pharmacology

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Summary1. Dopamine was shown to be released from the isolated lung of calves sensitized with horse serum by compound 48/80 and by specific antigen. 2. Dopamine contracts the bovine pulmonary artery and pulmonary vein. Phentolamine, the a-adrenoceptor blocking agent, inhibits this activity of dopamine and also strongly reduces the Schultz-Dale response of the pulmonary vessels. 3. The results are consistent with the suggestion that dopamine (together with histamine and 5-hydroxytryptamine) may participate in the pulmonary vasoconstriction associated with anaphylaxis in cattle.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Release of dopamine from bovine lung by specific antigen and by compound 48/80

Eyre

Deline

1971

British J Pharmacology

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“…Cardio-respiratory recordings were not made in this study. Minor roles in bovine -anaphylaxis were proposed for histamine and 5-hydroxytryptamine, but the possible involvement of kinins and slow-reacting substance (SRS-A) was suggested from the finding that sodium meclofenamate effectively protected conscious calves against the symptoms of anaphylactic shock (Aitken & Sanford, 1969b). The release of kinins during systemic anaphylaxis has now been established in this species .…”

Section: Introductionmentioning

confidence: 99%

“…Earlier studies employing antagonists (Aitken & Sanford, 1969b) indicated that antihistaminics and anti-5-hydroxytryptamine agents were not effective in-reducing the clinical signs of experimentally-induced anaphylaxis in calves. Cardio-respiratory recordings were not made in this study.…”

Section: Introductionmentioning

confidence: 99%

Acute systemic anaphylaxis in the calf

Eyre

Lewis

Wells

1973

British J Pharmacology

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Summary1. Acute systemic anaphylaxis in calves was characterized by marked systemic hypotension; hypertension in the pulmonary arteries and abdominal vena cava, and transient apnoea. Calves responded with a second reaction to antigen, but a third anaphylactic response could not be evoked. 2. Suppression of systemic anaphylaxis could not be effected with mepyramine, whereas methysergide or diethylcarbamazine each suppressed anaphylaxis by 50%. Disodium cromoglycate alone did not inhibit anaphylaxis: however, when disodium cromoglycate was combined with diethylcarbamazine almost total suppression (85%) was achieved. Sodium meclofenamate also was a powerful inhibitor of anaphylaxis (80%). It is tentatively suggested that slow reacting substance (SRS-A) may be an important mediator of bovine anaphylaxis. 3. Bilateral vagotomy did not modify the circulatory responses to injected histamine, 5-hydroxytryptamine (5-HT) or antigen, whereas the effects of these agents on ventilation (apnoea) were abolished by vagotomy. 4. Plasma histamine concentration was increased during anaphylaxis, whereas plasma 5-HT was not. Whole blood histamine concentration fell sharply and remained depressed during 20 min of anaphylactic shock. Reduced whole blood histamine levels probably reflect the severe leucopoenia in the calves. 5. Histamine concentrations in six tissues taken from calves subjected to anaphylaxis were not different from those in control calves; mast cells were of similar numbers to controls, but showed some swelling, granular spilling and metachromasia.6. Histamine, 5-HT, bradykinin and antigen caused increased pulmonary artery perfusion pressure and ventilation resistance in isolated lungs from sensitized calves. However, there was no difference in histamine and 5-HT concentration in perfusates obtained during antigen infusion of sensitized and control lungs. 7. Systemic anaphylaxis of calves may result from the interaction of histamine, 5-HT and SRS-A. The present data implicate (by indirect measurement) SRS-A as an important mediator of anaphylaxis in this species.

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“…Meclofenamate displays similar broadspectrum anti-allergic activity, being one of the most effective antagonists of bovine hy persensitivity yet tested [1,4,10,22], These in vivo studies employed a dose of 2 mg/kg meclofenamate, resulting in a plasma concentration of 3X10~5A7 [2], This would be sufficient to inhibit histamine release from bovine granulocytes by 50%.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Antigen-Induced Histamine Release from Bovine Granulocytes by Several Anti-Allergic Agents

Holroyde¹,

Eyre²

1977

Int Arch Allergy Immunol

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Sensitised bovine granulocytes release histamine when exposed to antigen. Several anti-allergic agents, some previously shown to be active in cattle, were tested to investigate their modulation of this histamine release process. Diethylcarbamazine citrate potentiated release at low concentrations and inhibited at high concentrations. Sodium meclofenamate and PR-D-92-EA were potent inhibitors. Acetylsalicyclic acid and ICI 74,917 inhibited at high concentrations. Disodium cromoglycate was relatively ineffective, although it potentiated histamine release at low concentrations.

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Protection of Cattle against Experimentally Induced Anaphylaxis

Cited by 20 publications

References 7 publications

Release of dopamine from bovine lung by specific antigen and by compound 48/80

Release of dopamine from bovine lung by specific antigen and by compound 48/80

Acute systemic anaphylaxis in the calf

Modulation of Antigen-Induced Histamine Release from Bovine Granulocytes by Several Anti-Allergic Agents

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