Protection From Type 1 Diabetes by Vitamin D Receptor Haplotypes

Ramos-Lopez, Elizabeth; Jansen, Thomas; Ivaškevičius, Vytautas; Kahles, H.; Klepzig, C.; Oldenburg, Johannes; Badenhoop, Klaus

doi:10.1196/annals.1375.050

Cited by 58 publications

(42 citation statements)

References 19 publications

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“…Certain allelic variants in VDR have been related to diabetes. In a German population, combinations of BsmI/ ApaI/TaqI influenced susceptibility to type 1 diabetes (T1D) [5]. In a Taiwanese population the AA genotype of ApaI polymorphism was associated with T1D.…”

Section: Introductionmentioning

confidence: 99%

Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Rivera-León

Palmeros-Sánchez

Llamas-Covarrubias

et al. 2015

Endokrynologia Polska

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Section: Introductionmentioning

confidence: 99%

Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Rivera-León

Palmeros-Sánchez

Llamas-Covarrubias

et al. 2015

Endokrynologia Polska

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“…In humans, the vitamin D status is a priori not likely to signal male health, and it is therefore not terribly likely, although not totally excluded, that provitamin D plays a role as a pheromone in humans as well, but this observation in the amphibians illustrates that this substance still holds surprises and has a plethora of nonclassical actions, for example, in immune function (8), ␤ cell function (29,30), apoptosis (31), cell-cycle control (32), and control of renin secretion (33), to mention only a few. Deservedly, these nonclassical actions, called "pleiotropic" (literally "directed in diverse directions"), have recently attracted considerable interest in the renal community (34).…”

Section: Results Of the Readoutsmentioning

confidence: 99%

Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension

Crowley¹,

Gurley²,

Herrera³

et al. 2007

Journal of the American Society of Nephrology

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T he late Arthur Guyton had postulated that even in the absence of primary renal disease of the kidney, a change in renal function, more precise, resetting of the BP/natriuresis relationship, is a prerequisite for a persistent rise of BP (1,2). The hypothesis that resetting of renal sodium handling plays a dominant role in the genesis of "essential hypertension," which is undoubtedly a polygenic condition, is further supported by the findings in monogenic forms of hypertension: Virtually all forms identified so far (3,4) have turned out to be linked to increased tubular net reabsorption of sodium.The postulate of an overriding role of the kidney has not gone uncontested, however, and the results of a number of studies have been interpreted to indicate that persistent BP elevation may also be caused by primary changes of resistance vessels (5-8). This argument is weakened by the objection that co-involvement of the renal vasculature has not been consistently excluded in these studies. This point is of interest, because-at least in the model of the spontaneously hypertensive rat-narrowing of the afferent arterioles precedes the rise in BP and presumably contributes to it (9).Despite their mostly normal plasma renin activity even in patients with essential hypertension, the BP frequently responds to angiotensin-converting enzyme inhibitors, suggesting that the renin-angiotensin system (RAS) plays a pathogenetic role, an effect that obviously must be mediated through the angiotensin II (AngII) type 1 (AT1) receptor. It is true that transplantation of the kidney of an immunocompatible wild-type mouse into a mouse that lacks the AT1 receptor does not fully restore the BP to normal values, suggesting that extrarenal territories make at least some nonredundant contribution to BP regulation (10), but this observation by no means excludes an overriding role of the renal RAS in the long-term regulation of BP.Apart from the kidney, the AT1 receptor is expressed in several tissues that might well contribute to long-term BP regulation: Vessels (11), adrenal glands (12), and particularly cardiovascular control centers in the brain (13). A potential role of the latter in the regulation of BP would not be unexpected given the massive hypotensive response to intracerebroventricular injection of angiotensin receptor blockers (14).An overriding role of such extrarenal AT1 receptors could be excluded, however, by the elegant experiment by Crowley et al. (15), which used isolated manipulation of the renal AT1 receptor. Another recent controversy that was addressed by this study (15) has focused on the issue of whether blockade of the RAS has BP-independent beneficial effects on hypertensioninduced target organ damage, particularly on left ventricular hypertrophy (LVH). Meta-analyses had suggested more rapidly appearing and more intense reversal of LVH under blockade of the RAS compared with alternative antihypertensive agents (16), but such clinical observations do not definitely exclude confounding, among others, by differences betw...

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“…Recently, Ramos-Lopez et al investigated 11 polymorphisms, also including the same four polymorphisms from our study, in German families. They found several VDR gene haplotypes to be negatively associated with T1DM (Ramos-Lopez et al 2006). Mimbacas et al investigated three VDR SNPs and found FokI to be an indicator for susceptibility to T1DM in a Uruguayan population (Mimbacas et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia

et al. 2007

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Type 1 diabetes mellitus (T1DM) is a disease characterised by the autoimmune destruction of insulinproducing pancreatic b cells. Vitamin D is a known immune system modulator and its effects are exerted via the vitamin D receptor (VDR). Several VDR gene single nucleotide polymorphisms (SNPs) have been commonly studied in relation to T1DM. The aim of this study was to evaluate the role of VDR gene variation in T1DM susceptibility by genotyping four SNPs (FokI-rs10735810, TaqI-rs731236, BsmI-rs1544410, and Tru9I-rs757343) in 160 case-parent trio samples from the population of South Croatia. We observed overtransmission of Tru9I allele G and undertransmission of the Tru9I-BsmI A-A haplotype from parents to affected children (P = 0.032, P = 0.002, respectively). These results indicate a possible role of the VDR gene in T1DM aetiology. In conclusion, this familybased study presents some evidence of association of specific VDR gene variants with T1DM in the population of South Croatia.

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Protection From Type 1 Diabetes by Vitamin D Receptor Haplotypes

Cited by 58 publications

References 19 publications

Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension

Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia

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