Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Rivera-León, Edgar Alfonso; Palmeros-Sánchez, Beatriz; Llamas-Covarrubias, Iris-Monserrat; Fernández, Socorro; Armendáriz‐Borunda, Juan; González-Hita, Mercedes; Bastidas-Ramirez, Blanca-Estela; Zepeda‐Moreno, Abraham; Sánchez‐Enríquez, Sergio

doi:10.5603/ep.2015.0042

Cited by 27 publications

(13 citation statements)

References 16 publications

(16 reference statements)

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“…More recent attention has been focused on the possible role of VDR gene polymorphisms in the development of a range of diseases, including osteoarthritis, 17 Parkinson disease, 18 diabetes, 19 as well as CAD. 20 , 21 However, the results of VDR gene polymorphisms in CAD are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

Lü

Guo

et al. 2016

Medicine

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Vitamin D receptor (VDR) polymorphisms were indicated to be associated with coronary artery disease (CAD); however, published studies reported inconsistent results.The aim of this meta-analysis is to reach a more accurate estimation of the relationship between VDR genetic polymorphisms and CAD risk.Eligible studies were retrieved by searching PubMed, Embase, VIP, Wanfang and China National Knowledge Infrastructure databases. Included and excluded criteria were formulated. The case group was patients with CAD, and the control group was healthy subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate VDR polymorphisms associations with CAD risk. Heterogeneity was evaluated by Q statistic and I2 statistic.Seven studies of a total of 2306 CAD patients and 4151 control subjects met the inclusion criteria. The pooled results from Taq1 showed increased risk in allelic model (OR = 1.14, 95% CI = 1.02–1.28), dominant model (OR = 1.21, 95% CI = 1.02–1.43), heterozygote model (OR = 1.19, 95% CI = 1.00–1.1.42), and homozygote model (OR = 1.27, 95% CI = 1.01–1.61). Besides, Fok1 T > C showed decreased risk in allelic model (OR = 0.81, 95% CI = 0.65–1.00) and Fok1 A > G also showed decreased risk in allelic model (OR = 0.67, 95% CI = 0.45–1.00) and recessive model (OR = 0.55, 95% CI = 0.31–0.97). In Caucasian subgroup, Bsm1showed increased risk in allelic model (OR = 1.23, 95% CI = 1.02–1.47), heterozygote model (OR = 1.20, 95% CI = 1.00–1.44), and homozygote model (OR = 1.22, 95% CI = 1.02–1.45). In CAD patients with type 2 diabetes mellitus (T2DM), Apa1showed a decreased risk in heterozygote model (OR = 0.80, 95% CI = 0.66–0.98); however, increased risk in recessive model (OR = 5.00, 95% CI = 2.74–9.13) was discovered in CAD patients without T2DM.The Fok1 polymorphism may play a protective role in CAD, and the possible protective role in Apa1 CA genotype in CAD patients with T2DM needs further studies. The Taq1 polymorphism is found to be associated with a significant increase in CAD risk based on our analysis; moreover, increased risk in Apa1 polymorphism in CAD patients without T2DM and Bsm1 polymorphism in Caucasian group is also detected.

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Section: Introductionmentioning

confidence: 99%

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

Lü

Guo

et al. 2016

Medicine

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“…An earlier literature review study showed that of 15 studies, none of which showed a significant association between the Apa-I Vitamin D receptor gene polymorphism and the risk of T2DM (n = 171-4563), as well as the two other meta-analyzes that analyzed the risk of T2DM in 3871 individuals [18], [19], [20]. Susceptibility to suffer from T2DM is related with changes in the ability of Vitamin D receptors to bind to 1,25(OH)D. Polymorphism of the Apa-I Vitamin D receptor alters the activity and affinity of this receptor binding to 1,25(OH)D. Changes in activity and affinity of Vitamin D receptors will be changed circulating of 1,25(OH)D which, in turn, affects sensitivity and resistance of insulin [10], [21]. The previous studies demonstrated the AA (GG) genotype of the Apa-I Vitamin D receptor gene polymorphism were significantly associated with lower insulin resistance (p = 0.035), in response to Vitamin D supplementation [22].…”

Section: Discussionmentioning

confidence: 99%

“…The previous studies on the T2DM population in Jeddah, Saudi Arabia, showed the genotype and allele of the Apa-I Vitamin D receptor gene polymorphism as a risk factor for developing T2DM [8], but on the T2DM population in Turkey and Mexico showed the different results [9], [10]. Based on differences in the previous studies in various populations, this present study aims to analyze the role of the Apa-I Vitamin D receptor gene polymorphism in T2DM patients in the Universitas Sumatera Utara Hospital.…”

Section: Introductionmentioning

confidence: 97%

The Role of Apa-I Vitamin D Receptor Gene Polymorphism in Type 2 Diabetes Mellitus

Sari

Rusdiana

Daulay

2021

Open Access Maced J Med Sci

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic syndrome caused by insulin secretion abnormalities, insulin action, or both. Gene polymorphism is a risk factor of T2DM. AIM: This study aims to see the role of Apa-I Vitamin D receptor gene polymorphism on T2DM. METHODS: This study was an analytic observational with a case–control approach, consisting of 70 T2DM patients and 70 healthy subjects as a control. Genotyping of the Apa-I Vitamin D receptor gene polymorphism was performed using the polymerase chain reactions-restriction fragment length polymorphisms method. The role of the Apa-I Vitamin D receptor gene polymorphism and the risk of T2DM were analyzed using the Chi-square test. RESULTS: The results showed that there was a significant association between codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism with the risk of T2DM (p < 0.05; odds ratio [OR] = 0.204, 95% confidence interval [CI] = 0.063–0.662; OR = 0.337, 95% CI = 0.113–1.004; OR = 0.367, 95% CI = 0.180–0.747, respectively), but not in codominant (GT genotype) and over-dominant models (p > 0.05). CONCLUSION: This study shows a role of the codominant (TT genotype); dominant; recessive models of the Apa-I Vitamin D receptor gene polymorphism on T2DM, but not in codominant (GT genotype) and over-dominant models.

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“…BsmI (rs1544410), ApaI (rs7975232) and FokI (rs2228570) were three common SNPs in VDR gene polymorphism. More and more recent attention has been focused on the possible role of VDR gene polymorphisms in the development of a range of diseases, including diabetes [ 27 ], as well as CAD [ 28 – 30 ]. Some previous studies also concluded inconsistent results on association between VDR gene and CHD risk.…”

Section: Discussionmentioning

confidence: 99%

Interactions betweenvitamin D receptor(VDR) gene andInterleukin-6gene and environment factors on coronary heart disease risk in a Chinese Han population

Guan

et al. 2017

Oncotarget

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AimsTo investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (IL- 6) and vitamin D receptor (VDR) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population.MethodsHardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Stratified analysis for gene- smoking interaction was investigated by logistic regression.ResultsCHD risk was significantly higher in carriers with the C allele of rs1800796 within IL-6 gene than those with GG genotype (GC+ CC versus GG), adjusted OR (95%CI) =1.62 (1.19-2.23); CHD risk was also higher in carriers with the T allele of rs2228570 within VDR gene than those with CC genotype (CT+ TT versus CC), adjusted OR (95%CI) = 1.68 (1.26-2.17). However, we did not find any direct associations of the others SNPs in IL- 6 and VDR gene with CHD risk. We also found a significant interaction between rs1800796 and smoking, the cross-validation consistency of this two- locus model was 10/ 10, and the testing accuracy was 60.11%. Current smokers with rs1800796- GC or CC genotype have the highest CHD risk, compared to never- smokers with rs1800796- GG genotype within IL- 6 gene, OR (95%CI) = 2.57 (1.74 -3.46).ConclusionsWe found that the C allele of rs1800796 within IL-6 and T allele of rs2228570 within VDR gene, interaction between rs1800796 and smoking were all associated with increased CHD risk.

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Polimorfizmy genu receptora witaminy D (TaqI oraz ApaI) oraz cyrkulacja osteokalcyny u pacjentów chorujących na cukrzycę typu 2 i osób zdrowych

Cited by 27 publications

References 16 publications

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease

The Role of Apa-I Vitamin D Receptor Gene Polymorphism in Type 2 Diabetes Mellitus

Interactions betweenvitamin D receptor(VDR) gene andInterleukin-6gene and environment factors on coronary heart disease risk in a Chinese Han population

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