Protection by Zinc-Metallothionein (ZnMT) against Cadmium-Metallothionein-Induced Nephrotoxicity

Dorian, C; Klaassen, Curtis D.

doi:10.1006/faat.1995.1079

Cited by 18 publications

(10 citation statements)

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“…Dorian and Klaassen (1995) observed that cadmium in the metallothionein-bound form concentrated preferentially in the kidney, whereas inorganic Cd did not. Cd-MT administered orally appeared in the kidney in greater concentrations than in the liver, whereas Cd administered orally as CdCl 2 appeared in higher concentrations in the liver .…”

Section: Discussionmentioning

confidence: 86%

Accumulation of Dietary Cadmium (Cd) in Rabbit Tissues and Excretions: A Comparison of Lettuce Amended with Soluble Cd Salt and Lettuce with Plant-Incorporated Cd

Chan

Waisberg

et al. 2004

Journal of Toxicology and Environmental Health, Part A

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Quantifying the transfer of Cd from foods to mammalian target organs is key to estimating the health risk from this exposure; however, the bioaccumulation of Cd from foods is modified by many dietary components. Studies of dietary Cd absorption would be simpler if it were known that Cd added to foods as a soluble salt was as bioavailable as Cd incorporated during growth of the food species. Rabbits were fed, for 16 d, fresh lettuce containing cadmium incorporated into the lettuce during growth or added to the lettuce before feeding, or lettuce with no Cd but soluble Cd administered to the animals by gavage. There was a marked positive relationship between increased Cd dose and its accumulation in kidney; the slopes for the gavage and added treatments were not clearly different from the incorporated treatment; liver data were highly variable. In a 10-wk study of Cd-incorporated and -amended lettuce diets, for the incorporated and control diets there was less Cd accumulation in the kidneys, but not liver, per unit cumulative dose, than for the amended diet. Cd accumulation in the small intestine and Cd concentration in feces, both per unit daily dose, were smaller for the incorporated than for the control and amended diets; Cd concentrations in bile, urine, and serum, per unit daily dose, were higher in the control diet than values in the amended diet, which were higher than the incorporated diet. These differences could not be accounted for by variation in Fe or Zn contents of the diets. Thus, data suggest that Cd-amended diets overestimate bioaccumulation in kidney, an important target organ, by up to one-third, and that studies of short duration are not adequate to evaluate Cd bioavailability from food.

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Section: Discussionmentioning

confidence: 86%

Accumulation of Dietary Cadmium (Cd) in Rabbit Tissues and Excretions: A Comparison of Lettuce Amended with Soluble Cd Salt and Lettuce with Plant-Incorporated Cd

Chan

Waisberg

et al. 2004

Journal of Toxicology and Environmental Health, Part A

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“…It is involved in cell membrane stabilization, metallothionein (Mt) synthesis [9][10][11][12] and superoxide dismutase (Cu/Zn SOD) structure. Numerous studies have shown that Zn supply may reduce Cd absorption and accumulation, and also prevent or reduce the adverse actions of Cd [6,[13][14][15][16], whereas Zn deficiency can intensify Cd accumulation and toxicity [5,17,18].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium

Jemai

Messaoudi

Chaouch

et al. 2007

Journal of Trace Elements in Medicine and Biology

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“…Exposure to soluble and insoluble Cd compounds results in extensive kidney injury (Chan et al, 1993; Dorian and Klaassen, 1995; Ginsberg, 2012). The classical view for such injury is that Cd, in the form of conjugates with metallothionein, cysteine, or glutathione, is readily filtered by the glomerulus and then taken up by epithelial cells of the proximal tubules.…”

Section: Discussionmentioning

confidence: 99%

“…The classical view for such injury is that Cd, in the form of conjugates with metallothionein, cysteine, or glutathione, is readily filtered by the glomerulus and then taken up by epithelial cells of the proximal tubules. Cadmium–metallothionein conjugates, which get degraded within the renal proximal tubule cells, allow Cd to be released within the kidney, resulting in oxidative stress and/or alterations in epithelial cell adhesion (Dorian and Klaassen, 1995). Studies examining whether Cd from inhaled CdO NP results in elevated levels of oxidative stress in the kidneys at the present exposure levels (2.3 ng Cd/mg kidney in NP-exposed dams) are ongoing in our lab.…”

Section: Discussionmentioning

confidence: 99%

Effects of Maternal Exposure to Cadmium Oxide Nanoparticles During Pregnancy on Maternal and Offspring Kidney Injury Markers Using a Murine Model

Blum

Edwards

Prozialeck

et al. 2015

Journal of Toxicology and Environmental Health, Part A

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Nanoparticles (NP) are pervasive in many areas of modern life, with little known about their potential toxicities. One commercially important NP is cadmium oxide (CdO), which is used to synthesize other Cd-containing NP, such as quantum dots. Cadmium (Cd) is a well-known nephrotoxicant, but the nephrotoxic potential of CdO NP remains unknown, particularly when exposure occurs during pregnancy. Therefore, pregnant CD-1 mice were used to examine the effects of inhaled CdO NP (230 μg CdO NP/m3) on maternal and neonatal renal function by examining urinary creatinine and urinary biomarkers of kidney injury, including kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL). Inhalation of CdO NP by dams produced a fivefold increase in urinary Kim-1 with no marked effect on urinary creatinine levels. Kim-1 mRNA expression peaked by gestational day (GD) 10.5, and NGAL expression increased from GD 10.5 to 17.5. In addition, histological analyses revealed proximal tubular pathology at GD 10.5. Neonatal Kim-1 mRNA expression rose between postnatal days (PND) 7 and 14, with mammary glands/milk being the apparent source of Cd for offspring. These studies demonstrate that, similar to what is seen with other Cd forms, Cd associated with inhaled CdO NP results in renal injury to both directly exposed dam and offspring. As commercial uses for nanotechnology continue to expand throughout the world, risks for unintentional exposure in the workplace increase. Given the large number of women in the industrial workforce, care needs to be taken to protect these already vulnerable populations.

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Protection by Zinc-Metallothionein (ZnMT) against Cadmium-Metallothionein-Induced Nephrotoxicity

Cited by 18 publications

References 0 publications

Accumulation of Dietary Cadmium (Cd) in Rabbit Tissues and Excretions: A Comparison of Lettuce Amended with Soluble Cd Salt and Lettuce with Plant-Incorporated Cd

Accumulation of Dietary Cadmium (Cd) in Rabbit Tissues and Excretions: A Comparison of Lettuce Amended with Soluble Cd Salt and Lettuce with Plant-Incorporated Cd

Protective effect of zinc supplementation on blood antioxidant defense system in rats exposed to cadmium

Effects of Maternal Exposure to Cadmium Oxide Nanoparticles During Pregnancy on Maternal and Offspring Kidney Injury Markers Using a Murine Model

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