Protection by Neuroglobin Expression in Brain Pathologies

Báez, Eliana; Echeverrı́a, Valentina; Cabezas, Ricardo; Ávila-Rodriguez, Marco; Garcia-Segura, Luis Miguel; Barreto, George E.

doi:10.3389/fneur.2016.00146

Cited by 60 publications

(47 citation statements)

References 135 publications

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“…Studies suggest that the presence of neuroglobin, rather than preventing apoptosis, raises the level of insult required for apoptotic cascade initiation. 8 In our study, there were significant negative correlations between neuroglobin and hemoglobin levels. This may be explained by the relationship between neuroglobin and hemoglobin in terms of structure and function, and this may highlight the role of hemoglobin in the seizure process.…”

Section: Discussionsupporting

confidence: 52%

“…4 Neuroglobin, a new globin family member that is specifically expressed in neurons of the brain, has been reported by several experimental animal studies to have an endogenous neuroprotective effect against seizures, oxidative stress-related insults, and may play a role in valproic acid-induced neuroprotection, with poorly defined underlying mechanism. [5][6][7][8][9] Neuroglobin is a hemoprotein that binds to oxygen in a reversible manner with higher affinity than that of hemoglobin. Additionally, neuroglobin increases the availability of oxygen to the neurons and potentially limiting the brain damage.…”

Section: Introductionmentioning

confidence: 99%

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Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Mahgoob

Moussa

2020

Journal of Pediatric Epilepsy

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At least 20% of patients referred to pediatric epilepsy centers with the suspicion of epileptic seizures actually have other conditions. Neuroglobin is a new globin member which is highly expressed in the central and peripheral nervous systems. We aim to evaluate usefulness of neuroglobin to differentiate between epilepsy and other conditions that mimic epilepsy. Our study was conducted on 90 children divided into three groups: 30 patients with epileptic seizures, 35 children with nonepileptic paroxysmal disorder, and 25 apparently healthy, age and sex-matched children as a normal control. Complete blood count, blood chemistries including random blood glucose, calcium, sodium, in addition to serum prolactin, and neuroglobin were performed for all children. The study showed a significant increase of both serum neuroglobin and prolactin levels in epileptic group compared with nonepileptic paroxysmal disorder and control groups (p < 0.01). Serum neuroglobin showed 95% sensitivity and 95.7% specificity in the diagnosis of generalized seizures. Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Mahgoob

Moussa

2020

Journal of Pediatric Epilepsy

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“…These anti-apoptotic properties of Ngb have already been described by several other authors[29] [30] [38] [52][53] [55]. Another hypothesis of this result would be the fact of the presence of a significant proportion of CG + in stabilization phase under the treatment.…”

supporting

confidence: 69%

Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

Essone¹,

Angue²,

Belmalih³

et al. 2020

WJNS

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Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG +) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG +. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG + and 45 controls (CG −). The chi-2 test compared the proportions, and Spearman's test studied the correlations between quantitative variables (p < 5%). Results: CmNgb was 4.1 in CG + , versus 2.3 in CG − (p = 1.52 × 10 −5). CmGpx was 1144.7 in CG + , versus 752.8 in GC − (p = 0.0199). CmHIF-1α was 4.1 in CG + , versus 3.5 in CG − (p = 0.4530). CmCyt C was 2303.26 in CG + , versus 1750.44 in CG − (p = 0.0450). In CG + , there was a correlation between CmNgb and CmGpx (r = 0.417; p = 0.004), CmNgb and CmHIF-1α (r = 0.644; p = 1.8 × 10 −6), and between CmHIF-1α and CmGpx (r = 0.447; p = 0.002), CmHIF-1α and CmCyt C (r = 0.371; p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126; p = 0.370), as well as CmGpx and CmCyt C (r = 0.102; p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress bio-How to cite this paper: Nnang Essone,

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“…Neuroglobin (Ngb) is a protein discovered in 2000 by Burmester et al [1] [2]. It owes its name because of its preferential expression in the nervous system [1] [2] [3].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and Prognostic Interests of Plasmatic Neuroglobin during Stroke in Adult at the Acute Phase

Essone¹,

Allognon²,

Nkiéma³

et al. 2019

WJNS

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Introduction: Neuroglobin (Ngb) owes its name to its preferred location in the nervous system. Its plasma concentration increases during cerebral ischemia. However, the interest of its dosage in the diagnosis and the prognosis of the strokes in the adult is not defined. Objectives: To determine if plasmatic Ngb can be used as a diagnostic biomarker and prognostic for stroke in adults at the acute phase. Population and Methods: This was a prospective study in 69 people, including 39 suspected stroke (Cerebral ischemia or CI, Intracerebral hemorrhage or ICH) and 30 healthy volunteers (controls). The plasma concentration of Ngb (CmNgb in ng/ml) of the patients was determined at admission day (d1), at the third day (d3) and seventh day (d7). CmNgbtaken at d1 was compared between patients and controls. Its evolution over time, as well as its relation with the clinical parameters, including the Glasgow coma scale and the short-term mortality in stroke subjects was analyzed by the Mann and Whitney tests and the Wilcoxon test (p < 0.05). Results: At d1, the CmNgb of all types of stroke was 3.140 ± 2.700 ng/ml, and did not differ significantly from controls (0.303 ± 0.114 ng/ml, p = 0.070). On the other hand, it was higher in CI victims (5.800 ± 0.720 ng/ml) than in ICH (1.750 ± 0,090 ng/ml) (p = 0.030). It then decreased on d3 in CI victims (2.600 ± 0.112 ng/ml) and ICH (0.420 ± 0.211 ng/ml), returning to normal on d7 (0.420 ± 0.200 ng/ml for CI's, p = 0.001, and 0.360 ± 0.300 ng/ml for ICH, p = 0.002). There was a relationship between CmNgb, delay of How to cite this paper: Nnang Essone,

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Protection by Neuroglobin Expression in Brain Pathologies

Cited by 60 publications

References 135 publications

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

Diagnostic and Prognostic Interests of Plasmatic Neuroglobin during Stroke in Adult at the Acute Phase

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