At least 20% of patients referred to pediatric epilepsy centers with the suspicion of epileptic seizures actually have other conditions. Neuroglobin is a new globin member which is highly expressed in the central and peripheral nervous systems. We aim to evaluate usefulness of neuroglobin to differentiate between epilepsy and other conditions that mimic epilepsy. Our study was conducted on 90 children divided into three groups: 30 patients with epileptic seizures, 35 children with nonepileptic paroxysmal disorder, and 25 apparently healthy, age and sex-matched children as a normal control. Complete blood count, blood chemistries including random blood glucose, calcium, sodium, in addition to serum prolactin, and neuroglobin were performed for all children. The study showed a significant increase of both serum neuroglobin and prolactin levels in epileptic group compared with nonepileptic paroxysmal disorder and control groups (p < 0.01). Serum neuroglobin showed 95% sensitivity and 95.7% specificity in the diagnosis of generalized seizures. Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.

. We evaluated the clinical usefulness of glycated albumin (GA) and glycated hemoglobin (HbA1c) as indicators of glycemic control in type I diabetic (T1DM) children with and without iron deficiency anemia (IDA). Our prospective cross-sectional study was conducted on 147 T1DM children who were classified into Group I (with IDA) and Group II (without anemia). The participants were classified as controlled and uncontrolled based on mean blood glucose (MBG) in the past 30 days. The 5–12-yr-olds with MBG above 200 and 12–15-yr-olds with levels above 180 md/dl were considered uncontrolled. HbA1c increased significantly in the participants with IDA compared to those without anemia (p < 0.01). HbA1c in those with IDA showed insignificant difference between the controlled and uncontrolled (p = 0.5), while GA was significantly higher in the uncontrolled than the controlled (p = 0.3). Receiver operating characteristic (ROC) curve analysis showed that GA had 87.2% sensitivity and 75.8% specificity at a cut-off point of 16.9%. HbA1c at a cut-off point of 7.09% showed 80% sensitivity and 57.6% specificity. For prediction of uncontrolled diabetes in children with IDA, we concluded that HbA1c increases significantly in diabetic children with IDA. GA may be a useful alternative biomarker for evaluating the glycemic control in such children.