Protection by low-dose γ radiation on doxorubicin-induced nephropathy in rats pretreated with curcumin, green tea, garlic or l-carnitine

Radwan, Rasha R.; Shaban, Esmat A.; Kenawy, Sanaa A.; Salem, Hesham A.

doi:10.1016/j.bfopcu.2012.09.002

Cited by 10 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Much work has focused upon determining the mechanism underlying the protective effects of curcumin against DIN . The evidence suggests that the nephroprotective effects of curcumin can be attributed to functional preservation of mitochondria and maintaining redox balance …”

Section: Resultsmentioning

confidence: 99%

“…Much work has focused upon determining the mechanism underlying the protective effects of curcumin against DIN. [83][84][85][86][87] The evidence suggests that the nephroprotective effects of curcumin can be attributed to functional preservation of mitochondria and maintaining redox balance. [35][36][37][38] Cekmen reported that curcumin reversed the depletion of GSH levels and antioxidant enzyme activity in rats with acetaminophen-induced nephrotoxicity and normalized renal morphology.…”

Section: Mechanisms Of Curcumin's Protective Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

et al. 2019

View full text Add to dashboard Cite

Drug‐induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti‐inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug‐induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug‐induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Mechanisms Of Curcumin's Protective Effectsmentioning

confidence: 99%

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The experiments were conducted on nonlinear mature rats of both sexes by means of slow intraperitoneal DXR injection at a dose of 5 mg/kg per body weight weekly for four weeks. Clinical administration of DXR is an important fact to induce not only cardio-, but also nephro-and hepatotoxicity [18][19][20]. Therefore, interpretation of results assumes effect of the examined compounds on other toxic targets of the applied DXR dose as on the constituents of comorbidity.…”

Section: The Aimmentioning

confidence: 99%

Experimental models of kidney diseases to study pathogenetic mechanisms and efficacy of pharmacological correction against the background of comorbid pathology

Seredynska

Filipets

et al. 2019

ZMJ

View full text Add to dashboard Cite

Экспериментальные модели заболеваний почек для исследований патогенетических механизмов и эффективности фармакологической коррекции на фоне коморбидной патологии Н. Н. Серединская, Н. Д. Филипец, Е. А. Филипец, К. В. Слободян, А. И. Гоженко Цель работы -освещение современных моделей заболеваний почек, сочетанных с другими патологическими состояниями, для экспериментальных исследований патогенетических механизмов и эффективности фармакологической коррекции.Рассмотрены экспериментальные модели, которые целесообразно использовать для исследования патогенеза и эффективности средств фармакологической коррекции коморбидной патологии. Акцентировано внимание на моделях, воспроизводящих кардиоренальный, гепаторенальный синдром и полиорганное гипоксическое гистогемическое повреждение у лабораторных крыс. Эти модели характеризуются легким моделированием, воспроизведением патогенеза коморбидных заболеваний, наличием острого и хронического периода повреждения, индуцированного антибиотиком доксорубицином или экотоксикантами -сулемой, нитритом натрия, 2,4-динитрофенолом.Выводы. Представленные модели кардиоренального, гепаторенального синдромов и гипоксического повреждения организма являются оптимальными для проведения многоцелевых исследований физиологического, патофизиологического, фармакологического направлений с максимальным приближением результатов к клинико-терапевтическим особенностям коморбидной патологии.The aim of our study is to report about modern models of kidney diseases associated with other pathological conditions for experimental studies of pathogenic mechanisms and efficacy of pharmacological correction.The study deals with experimental models reasonably to be applied in investigation of comorbid pathology pathogenesis and efficacy of its pharmacological correction. The attention is focused on the models of cardio-renal, hepatic-renal syndromes and multiple organ hypoxic histochemical injury simulated in laboratory rats. These models are characterized by easy modeling, simulation of comorbidity pathogenesis, acute and chronic periods of diseases available, induced by the antibiotic Doxorubicin or exotoxins -corrosive sublimate, sodium nitrite, and 2,4-dinitrophenol.Conclusions. The models of cardio-renal, hepatic-renal syndromes and hypoxic histochemical injury of the body are found to be optimal to perform multipurpose studies of physiological, pathophysiological, pharmacological directions with maximal similarity of the results obtained to clinical-therapeutic peculiarities of comorbid pathology.Експериментальні моделі захворювань нирок для досліджень патогенетичних механізмів та ефективності фармакологічної корекції на тлі коморбідної патології Н. М. Серединська, Н. Д. Філіпець, О. О. Філіпець, К. В. Слободян, А. І. Гоженко Мета роботи -висвітлення сучасних моделей захворювань нирок, що поєднані з іншими патологічними станами, для експериментальних досліджень патогенетичних механізмів та ефективності фармакологічної корекції.Розглянуті експериментальні моделі, які доцільно використовувати для дослідження пат...

show abstract

“…The use of DOX has been limited largely due to possible diverse cardiac, renal, haematological and testicular toxicities (Radwan et al, 2012).DOX induces rat nephropathy, which is characterized by massive proteinuria, hypoalbuminemia and dyslipidemia (Radwan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

EL-Shater

Salman

Kasem

et al. 2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

Protection by low-dose γ radiation on doxorubicin-induced nephropathy in rats pretreated with curcumin, green tea, garlic or l-carnitine

Cited by 10 publications

References 31 publications

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

Experimental models of kidney diseases to study pathogenetic mechanisms and efficacy of pharmacological correction against the background of comorbid pathology

Effects of Fullerene C60 and Fruit Extract of Balanites aegyptiaca Plant on the Nephrotoxicity and Hematotoxicity Induced by Doxorubicin in Diabetic Male Albino Rats.

Contact Info

Product

Resources

About