Abstract:Drug‐induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti‐inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug‐induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in so… Show more
“…Over 100 in vitro and animal studies show that curcumin ameliorates many causes of kidney damage ( Supplementary data, Fig. S1 depicts curcumin's effects relevant to CKD) [ 9–11 ], and some small clinical trials suggest curcumin reduces albuminuria in patients with CKD ( Supplementary data, Table S1 ).…”
Background
Curcumin is a commonly used herbal supplement with anti-inflammatory and anti-fibrotic properties. Animal studies and small human trials suggest curcumin reduces albuminuria in patients with chronic kidney disease. Micro-particle curcumin is a new, more bioavailable formulation of curcumin.
Methods
To determine whether micro-particle curcumin versus placebo slows the progression of albuminuric chronic kidney disease we conducted a randomized, double-blind, placebo-controlled trial with 6-month follow-up. We included adults with albuminuria (a random urine albumin-to-creatinine ratio >30 mg/mmol [265 mg/g] or a 24-hour urine collection with more than 300 mg of protein) and an estimated glomerular filtration rate (eGFR) between 15 and 60 ml/min per 1.73 m2 within the 3 months before randomization. We randomly allocated participants 1:1 to receive micro-particle curcumin capsules (90 mg/day) or matching placebo for 6 months. After randomization. The co-primary outcomes were the changes in albuminuria and the eGFR.
Results
We enrolled 533 participants, but 4/265 participants in the curcumin group and 15/268 in the placebo group withdrew consent or became ineligible. The 6-month change in albuminuria did not differ significantly between the curcumin and placebo groups (geometric mean ratio 0.94, 97.5% confidence interval [CI]: 0.82 to 1.08, P = .32). Similarly, the 6-month change in eGFR did not differ between groups (mean between-group difference -0.22 mL/min per 1.73m2, 97.5% CI: -1.38 to 0.95, P = 0.68).
Conclusions
Ninety milligrams of micro-particle curcumin daily did not slow the progression of albuminuric chronic kidney disease over six months. Trial Registration: ClinicalTrials.gov Identifier: NCT02369549
“…Over 100 in vitro and animal studies show that curcumin ameliorates many causes of kidney damage ( Supplementary data, Fig. S1 depicts curcumin's effects relevant to CKD) [ 9–11 ], and some small clinical trials suggest curcumin reduces albuminuria in patients with CKD ( Supplementary data, Table S1 ).…”
Background
Curcumin is a commonly used herbal supplement with anti-inflammatory and anti-fibrotic properties. Animal studies and small human trials suggest curcumin reduces albuminuria in patients with chronic kidney disease. Micro-particle curcumin is a new, more bioavailable formulation of curcumin.
Methods
To determine whether micro-particle curcumin versus placebo slows the progression of albuminuric chronic kidney disease we conducted a randomized, double-blind, placebo-controlled trial with 6-month follow-up. We included adults with albuminuria (a random urine albumin-to-creatinine ratio >30 mg/mmol [265 mg/g] or a 24-hour urine collection with more than 300 mg of protein) and an estimated glomerular filtration rate (eGFR) between 15 and 60 ml/min per 1.73 m2 within the 3 months before randomization. We randomly allocated participants 1:1 to receive micro-particle curcumin capsules (90 mg/day) or matching placebo for 6 months. After randomization. The co-primary outcomes were the changes in albuminuria and the eGFR.
Results
We enrolled 533 participants, but 4/265 participants in the curcumin group and 15/268 in the placebo group withdrew consent or became ineligible. The 6-month change in albuminuria did not differ significantly between the curcumin and placebo groups (geometric mean ratio 0.94, 97.5% confidence interval [CI]: 0.82 to 1.08, P = .32). Similarly, the 6-month change in eGFR did not differ between groups (mean between-group difference -0.22 mL/min per 1.73m2, 97.5% CI: -1.38 to 0.95, P = 0.68).
Conclusions
Ninety milligrams of micro-particle curcumin daily did not slow the progression of albuminuric chronic kidney disease over six months. Trial Registration: ClinicalTrials.gov Identifier: NCT02369549
“…master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2) induction, mitochondrial dysfunction inhibition, inflammatory response amelioration, antioxidant enzymes preservation, and oxidative stress prevention. 44 Curcumin was effective in the prevention of an increase in serum levels of urea, creatinine, and MDA, compared with the control group. In a study by Mercantepe et al, the effects of curcumin in cisplatininduced nephrotoxicity in rats was evaluated.…”
Background: The last-line agent for gram-negative bacteria that have developed resistance towards commonly used antibiotics is polymyxin E (PolyE). The renal toxicity attributed to this agent limits its use, proper dosing, and eventually its clinical efficacy. Although the exact mechanism of PolyE-induced nephrotoxicity is not obvious, some investigations suggest the role of oxidative stress and its associated events in this complication. Curcumin (CUR) is a potent antioxidant molecule. The aim of the current investigation was the evaluation of the potential nephroprotective properties of CUR in PolyE-treated mice. Materials and Methods: Mice were randomly allocated into five groups (n = 8 per group). PolyE (15 mg/kg/day, i.v, for 7 days) alone or in combination with CUR (10, 100 and 200 mg/kg, i.p) were administered to mice. Renal injury biomarkers, in addition to markers of oxidative stress and kidney histopathological alterations, were evaluated. Results: Plasma creatinine (Cr) and blood urine nitrogen (BUN) significantly raised in PolyE group. Oxidative stress biomarkers consisting of reactive oxygen species (ROS) and lipid peroxidation (LPO) also increased, and concomitantly GSH and antioxidant capacity of renal cells significantly decreased following the use of PolyE. Interstitial nephritis, tissue necrosis, and glomerular atrophy were all induced by the use of PolyE in the mice kidney. CUR (10, 100, and 200 mg/kg, i.p) treatment alleviated PolyE-induced oxidative stress and histopathological alterations in the kidney tissue significantly. Conclusion: According to the results of this study, CUR has a protective role against renal toxicity induced by PolyE. Hence, more research is necessary until this compound could be clinically applicable to alleviate PolyE-induced renal injury.
“…Given the problems mentioned above, many researchers have tried solving the problems in nephrotoxicity caused by NSAIDs by using compound preparations (İlbey et al., 2009 ; Ortiz et al., 2010 ; Gao et al., 2019 ; Motaharinia et al., 2019 ); it was demonstrated that the extracts of Phyllanthus amarus Sch, umach. & Thonn (Adeneye & Benebo, 2008 ), Trifolium repens leaf extract (Ahmad & Zeb, 2020 ), and Salacia oblonga (Palani et al., 2011 ), when combined with NSAIDs, can exert their unique pharmacological effects as well as protect the kidney.…”
Ibuprofen (IBU) was a widely used NSAID (a type of nonsteroidal anti-inflammatory drug) worldwide, and many drug deliveries had been reported to enhance bioavailability. However, higher bioavailability would increase the danger of renal injury caused by oxidative stress. This study prepared IBU-
Polygonatum sibiricum
polysaccharide (IBU-PSP) drug delivery system via mechanochemical method. Due to drug delivery and renal protection effect of
Polygonatum sibiricum
polysaccharide (PSP), the solubility of IBU-PSP was increased 8.22 times, and the bioavailability was increased 2.52 times compared with IBU, carrageenin-induced rat paw edema test also increased. Meanwhile, short-term and long-term renal injuries induced by IBU were notable decreases. In conclusion, IBU-PSP was a multifunctional drug delivery system with superior anti-inflammatory and renal protection effects. It will benefit from developing high-efficiency NADIs preparations with safer clinical applications while providing an efficient and energy-saving technology for polysaccharide drug delivery.
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