1992
DOI: 10.1254/jjp.60.63
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Protection by Halothane of the Vagal Baroreflex System from Transient Global Cerebral Ischemia in Dogs.

Abstract: ABSTRACT-A possible cerebroprotective effect of halothane was investigated in a canine model of 5 min global cerebral ischemia.In pentobarbital-anesthetized dogs, additional inhalation of 0.5 to 1%halothane prior to ischemia prevented the post-ischemic dysfunction of the vagal component of reflex bradycardia. In contrast, pretreatment with thiopental at 10 mg/kg, i.v. failed to prevent it. The influ ence of ischemia in the absence of anesthetics was similar to that under barbiturate anesthesia. The re sults su… Show more

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“…However, such a cytoprotective effect of nicorandil has yet to be established in organs other than the heart. In this context, the present study was conducted to investigate a possible cerebroprotective effect of nicorandil in a canine model of transient global cerebral ischaemia in which we have already confirmed the cerebroprotective effects of some drugs including flunarizine (Kurihara et al, 1989b;1990b), ifenprodil (Kurihara et al, 1990b), beraprost (Kurihara et al, 1990a) and halothane (Kurihara et al, 1992). The results were compared with those obtained with nitroglycerin and nicardipine.…”
Section: Introductionmentioning
confidence: 88%
“…However, such a cytoprotective effect of nicorandil has yet to be established in organs other than the heart. In this context, the present study was conducted to investigate a possible cerebroprotective effect of nicorandil in a canine model of transient global cerebral ischaemia in which we have already confirmed the cerebroprotective effects of some drugs including flunarizine (Kurihara et al, 1989b;1990b), ifenprodil (Kurihara et al, 1990b), beraprost (Kurihara et al, 1990a) and halothane (Kurihara et al, 1992). The results were compared with those obtained with nitroglycerin and nicardipine.…”
Section: Introductionmentioning
confidence: 88%