Protection by catatoxic steroids against dihydrotachysterol intoxication

Selye, Hans; Yeghiayan, E.; Mandeville, Rosemonde

doi:10.1016/0021-9150(70)90069-9

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Digitoxin toxicity is decreased only by PCN, while that of proscillaridin by both phénobarbital and the steroid (Selye, et al, 1972g). Phénobarbital increases, while PCN abolishes, cyclophosphamide toxicity without altering the antineoplastic effect of the drug .…”

Section: / Cns-depressantsmentioning

confidence: 91%

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Szabó¹

1979

Acta Endocrinologica

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The endocrine system plays an important role in the adaptation of the organism to environmental stimuli: it influences both specific and nonspecific responses. The ,,emergency reaction" and the ,,stress syndrome" were recognized a long time ago, but they remain very complex processes. Elucidation of their mechanism(s) of action is difficult, and the importance of individual hormones is not yet clearly understood. extracts and corticosterone, but not by DOC (Jensen & Grattan, 1940).

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Section: / Cns-depressantsmentioning

confidence: 91%

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Szabó¹

1979

Acta Endocrinologica

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“…A trace of inhibition was apparently also obtained by progesterone, prednisolone and triamcinolone, but with the latter two compounds the mortality was so high that the mildness of calcification may have been due to the premature death of the animals. Desoxycorticosterone had no protective action (10).…”

Section: Steroid Hormones and Resistance To Stressmentioning

confidence: 99%

Stress and Aging*

Selye

1970

J American Geriatrics Society

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The experimental “aging” exemplified in the progeria‐like syndrome (induced by dihydrotachysterol, DHT, in rats) is not the cause but the consequence of disturbed calcium metabolism. Certain anabolic steroids can prevent the loss of body weight (protein) and the abnormal tissue calcification. Moreover, steroidal substances designated “catatoxic” have been found to play a role in adaptive reactions, particularly the maintenance of resistance to stress. Thus the anti‐DHT effect of the steroids is not due to their antimineralocorticoid or anabolic action, but to their catatoxic (antitoxic) potency. An experimental biochemical disease model—the “Electrolyte‐Steroid‐Cardiopathy with Necrosis” (ESCN)—was developed to demonstrate a typical pluricausal disease in which several factors operate conjointly to produce a lesion. Glucomineralo‐corticoids plus sodium salts were outstanding factors in the production of cardiac necrosis. This experimental necrosis could be prevented by KCl or MgCl2. However, oral administration of KCl has many drawbacks for the prophylaxis or treatment of myocardial infarction; more convenient and lasting methods of providing potassium are needed. Certain catatoxic steroids also were found to be efficacious in preventing ESCN. These data may eventually help in finding ways to combat spontaneous aging. Aging has no specific cause. Body hormones and numerous other factors play decisive roles.

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“…Several years later systematic studies, with a very large number of steroids, revealed that the anti-DHT effect parallels much more closely the anabolic than the virilizing activity [30,31], whereas cortisol, estradiol and desoxycorticosterone actually diminish DHT resistance [4], Considerable progress was made in the elucidation of this 'not corticoid dependent type of resistance' when it became clear that there exists a special class o f 'catatoxic steroids', which-unlike the 'syntoxic' glucocorticoidsdo not merely adjust the body's response to toxicants but actually attack the latter. Usually-though not always-this is achieved by increasing the rate of metabolic degradation in the liver.…”

Section: Introductionmentioning

confidence: 99%

Influence of Various Catatoxic Steroids Upon Chronic Dihydrotachysterol Intoxication

Selye¹

1971

Horm Res Paediatr

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In rats, the catabolism normally induced by chronic dihydrotachysterol (DHT) intoxication is counteracted (in approximately decreasing order of activity) by: norbolethone, ethylestrenol, CS-1 and pregnenolone-16α-carbonitrile (PCN). Spironolactone was previously shown to antagonize DHT in acute experiments. However in the chronic experiments reported here, it is inactive in this respect and even abolishes the high anti-DHT of norbolethone and ethylestrenol. Several possible mechanisms are discussed which might explain these antagonisms, for example: (1) Spironolactone may act by accelerating the enzymatic degradation of the protective anabolic steroids. (2) The 2 types of steroids may compete with each other for receptor sites. (3) Spironolactone and the anabolics may exert opposing actions on DHT metabolism.

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Protection by catatoxic steroids against dihydrotachysterol intoxication

Cited by 9 publications

References 6 publications

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Stress and Aging*

Influence of Various Catatoxic Steroids Upon Chronic Dihydrotachysterol Intoxication

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