Abstract:In rats, the catabolism normally induced by chronic dihydrotachysterol (DHT) intoxication is counteracted (in approximately decreasing order of activity) by: norbolethone, ethylestrenol, CS-1 and pregnenolone-16α-carbonitrile (PCN). Spironolactone was previously shown to antagonize DHT in acute experiments. However in the chronic experiments reported here, it is inactive in this respect and even abolishes the high anti-DHT of norbolethone and ethylestrenol. Several possible mechanisms are discussed which might… Show more
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