Protection and viability of fruit seeds oils by nanostructured lipid carrier (NLC) nanosuspensions

Krasodomska, Olga; Paolicelli, Patrizia; Cesa, Stefania; Casadei, Maria Antonietta; Jungnickel, Christian

doi:10.1016/j.jcis.2016.06.041

Cited by 26 publications

(17 citation statements)

References 54 publications

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“…NLCs are composed of a mixture of solid lipid and bioactive liquid oil 14 that is in a solid state at RT, 15 and may be of great interest for encapsulation of unstable bioactive compounds. The solid lipid immobilizes the bioactive ingredients and thus enhances its chemical stability through reducing interactions with reactive agents at the interface or surrounding aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, Physicochemical Characterization and Oxidative Stability of Omega-3 Fish Oil/α-Tocopherol-co-Loaded Nanostructured Lipidic Carriers

et al. 2019

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Purpose: This study aimed to improve the pharmacokinetic behavior of polyunsaturated fatty acids (PUFAs) oxidation to enhance oxidative stability for inhibiting formation of toxic hydroperoxides, develops off-flavors and shortens shelf-life. Methods: Nanostructured lipid carrier (NLC) co-encapsulating omega-3 fish oil and α-tocopherol was successfully prepared by melt blending and hot sonication method to enhance the oxidative stability of the fish oil. Encapsulation efficiency (EE) and in vitro release, the oxidative stability of prepared nanoparticles (NPs) were measured using detection of peroxide value (PV) and thiobarbituric acid (TBA) during 40 days. Results: Electron microscopy and particle size analysis showed dispersed and homogenous NPs with an average diameter of 119 nm. Sustained oil release at a physiologic pH, and longterm stability in terms of the size, zeta, and dispersity of NPs was achieved after 75 days of storage. The omega-3 fish oil co-encapsulated with α-tocopherol in the NLC possessed better oxidative stability compared with the all other formulations. Also, it was found that the NLC as an encapsulation method was more successful to inhibit the formation of the primary oxidation products than the secondary oxidation products. Conclusion: Generally, these findings indicated that co-encapsulation of fish oil and α-tocopherol within the NLC can be a suitable delivery system in order to enrich foodstuffs, in particular clear beverages.

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Section: Introductionmentioning

confidence: 99%

“…17 NLCs can be easily engineered based on product requirements via modification in components during preparation. 15…”

Section: Introductionmentioning

confidence: 99%

Preparation, Physicochemical Characterization and Oxidative Stability of Omega-3 Fish Oil/α-Tocopherol-co-Loaded Nanostructured Lipidic Carriers

et al. 2019

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“…These lipid carriers can be environmentally-friendly produced without any organic solvent [ 10 ]. Easy scale-up of NLC synthesis provides a supplementary argument in favor of cosmetic and nutraceutical NLC applications [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

et al. 2018

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Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity was measured by α-Tocopherol Equivalent Antioxidant Capacity assay and was compared to those of both natural astaxanthin and α-tocopherol. Characterizations by dynamic light scattering, atomic force microscopy, and scattering electron microscopy techniques were carried out and showed spherical and surface negative charged particles with z-average and polydispersity values of ~60 nm and ~0.3, respectively. Astaxanthin loading was also investigated showing an astaxanthin recovery of more than 90% after synthesis of nanostructured lipid carriers. These results demonstrate the capability of the formulation to stabilize astaxanthin molecule and preserve and enhance the antioxidant activity.

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“…, Fragaria ananassa Duch ., etc.) , jojoba ( Simmondsia chinensis ) and coffee ( Coffea arabica L.) . Since jojoba oils can act as carrier oils for essential oils and lipophilic chemicals (e.g.…”

Section: Oils and Essential Oilsmentioning

confidence: 99%

“…Multilayered vesicle structures can be analysed by small‐angle X‐ray scattering (SAXS) . Chemical structures are determined by Fourier‐transform infrared (FTIR) and nuclear magnetic resonance (NMR), and the latter can also elucidate the liquid‐containing domains of liposomes and NLCs .…”

Section: Microstructure Composition and Encapsulation Efficiencymentioning

confidence: 99%

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

Yang

Liu

Han

et al. 2020

Intern J of Cosmetic Sci

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Today, there is a rising demand and ongoing search for novel plant-derived phytochemicals in the cosmetic market owing to the growing consumer expectations worldwide for green and natural health products. Various plant ingredients, including polyphenols, oils, volatile oils, vitamins and other herbal extracts, have been extensively used in herbal cosmetics. Recent advances in encapsulation technologies have greatly improved their chemical stability, biocompatibility, skin permeability and dermocosmetic efficiency when applied topically. This comprehensive review summarizes the up-to-date information on encapsulated plant ingredients tailored for dermocosmetic application with a focus on the development of novel delivery systems. An overview of the commonly used techniques for carrier characterization, performance-related properties and toxicological evaluation is also included, which might provide guidance for researchers to select or develop appropriate assay systems. PolyphenolsPolyphenols are secondary metabolites in plants, and the presence of the array of phenolic hydroxyl groups makes them potent free radical scavengers and antioxidants, which are favoured in antiageing cosmetics [1]. Encapsulation techniques are primarily employed to stabilize the easily reducible polyphenolic compounds during storage and processing, thereby enabling their cosmetic/ pharmaceutical uses. A good example is quercetin, a flavonoid from Sophora japonica L. with a pronounced antioxidative and anti-inflammatory activity but with poor water solubility and low skin

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Protection and viability of fruit seeds oils by nanostructured lipid carrier (NLC) nanosuspensions

Cited by 26 publications

References 54 publications

Preparation, Physicochemical Characterization and Oxidative Stability of Omega-3 Fish Oil/α-Tocopherol-co-Loaded Nanostructured Lipidic Carriers

Preparation, Physicochemical Characterization and Oxidative Stability of Omega-3 Fish Oil/α-Tocopherol-co-Loaded Nanostructured Lipidic Carriers

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

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