Protection Against Oxidative Stress and “IGF-I Deficiency Conditions”

Morón, Úrsula Muñoz; Castilla‐Cortázar, Inma

doi:10.5772/51047

Cited by 6 publications

(3 citation statements)

References 136 publications

(173 reference statements)

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“…GPx play also a crucial role breaking lipid peroxides to their alcohols, which protects cells from oxidative stress 6465. The expression of individual GPx is tissue-specific and has been classified into eight groups 6667. For example, GPx1 is the most abundant form and is present in all cells; GPx2 is exclusively expressed in the gastrointestinal track, providing a barrier against hydroperoxides produced in the diet, while plasma GPx (GPx3) is directed to extracellular compartments and is mainly expressed in tissues in contact with body fluids (i.e, kidney) (for a detailed review, see 68).…”

Section: Oxidative Stressmentioning

confidence: 99%

Mitochondrial stress management: a dynamic journey

Valera‐Alberni

Cantó²

2018

CST

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Mitochondria undergo continuous challenges in the course of their life, from their generation to their degradation. These challenges include the management of reactive oxygen species, the proper assembly of mitochondrial respiratory complexes and the need to balance potential mutations in the mitochondrial DNA. The detection of damage and the ability to keep it under control is critical to fine-tune mitochondrial function to the organismal energy needs. In this review, we will analyze the multiple mechanisms that safeguard mitochondrial function in light of in crescendo damage. This sequence of events will include initial defense against excessive reactive oxygen species production, compensation mechanisms by the unfolded protein response (UPR mt ), mitochondrial dynamics and elimination by mitophagy.

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Section: Oxidative Stressmentioning

confidence: 99%

Mitochondrial stress management: a dynamic journey

Valera‐Alberni

Cantó²

2018

CST

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“…GPx is vital for protecting cells against oxidative stress inhibiting lipid peroxidation [23]. Humans possess eight distinct GPx enzymes (GPx1-GPx8), which are located on chromosomes 3, 14, 5, 19, 6, 6, 1, and 5, respectively [24]. According to Drevet (2006) [25], GPx-1 is the predominant selenoperoxidase found in nearly all cellular types.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Defence in Labeo rohita to Biotic and Abiotic Stress: Insight from mRNA Expression, Molecular Characterization and Recombinant Protein-Based ELISA of Catalase, Glutathione Peroxidase, CuZn Superoxide Dismutase, and Glutathione S-Transferase

Parida,

Sahoo

2023

Antioxidants

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Fish possess numerous enzymatic antioxidant systems as part of their innate immunity. These systems have been poorly studied in Labeo rohita (rohu). The present study characterized and investigated the role of antioxidant genes in the defence mechanisms against two types of stressors, including infection and ammonia stress. Four key genes associated with antioxidant activity–catalase, glutathione peroxidase, glutathione S-transferase, and CuZn superoxide dismutase were successfully cloned and sequenced. These genes were found to be expressed in different tissues and developmental stages of rohu. The expression levels of these antioxidant genes in the liver and anterior kidney tissues of rohu juveniles were modulated in response to bacterial infection (Aeromonas hydrophila), parasite infection (Argulus siamensis), poly I:C stimulation and ammonia stress. Additionally, the recombinant proteins derived from these genes exhibited significant antioxidant and antibacterial activities. These proteins also demonstrated a protective effect against A. hydrophila infection in rohu and had an immunomodulatory role. Furthermore, indirect ELISA assay systems were developed to measure these protein levels in healthy as well as A. hydrophila and ammonia-induced rohu serum. Overall, this study characterized and emphasised the importance of the antioxidant mechanism in rohu’s defence against oxidative damage and microbial diseases.

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“…Antioxidants prevent oxidation of cell components, including lipids and proteins. They are thus, components capable of protecting cells against oxidative damage, playing beneficial roles in improving diseases conditions such as diabetes (Ametov et al, 2003;Munoz, and Castilla-Cortazar, 2012). Several sources are responsible for generating reactive oxygen species (ROS), including radiation, chemicals, deep-fried or spicy foods, and physical stress (Agrawal et al, 2011), which might lead to oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant activity‐guided fractionation of Daucus carota L. seed extract

Tijjani

Mohammed

Ahmed

et al. 2020

PNgAS

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Daucus carota Linn (carrot) seeds are medicinally useful in the management of diseases including diabetes mellitus. The present study investigates the in vitro antioxidant activities and phytochemical constituents of several fractions from aqueous seed extract of Daucus carota. D. carota seeds (78.8g) were pulverized and dissolved in 400 mL of distilled water for 24 hours. The crude extract obtained (16.4g, 20.8% yield) was partitioned in water/ethyl acetate (3:1) to yield ethyl acetate fraction (6.2g, 37.8% yield) and aqueous ethyl acetate fraction (7.6g, 46.3% yield) which was subjected to column chromatography. Thirteen (13) fractions obtained were evaluated for their in vitro antioxidant activities and screened for phytochemical constituents. The fractions exhibited in vitro antioxidant activities at 2 – 20 μg/mL with 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities (IC50 = 1.38 - 22.96 μg/mL), total antioxidant capacity (IC50 = 1.17 - 3.13 μg/mL) and nitric oxide scavenging activities (IC50 = 3.20 - 20.72 μg/mL). Fractions 4 – 8 expressed promising in vitro hydrogen peroxide (H2O2) antioxidant activities with IC50 comparable with that of ascorbic acid and butylated hydroxytoluene. The phytochemical screening of fractions 4 – 8 revealed the presence of alkaloids, flavonoids, and phenolics, which could be responsible for the antioxidant activities. The results suggest that fractions obtained from Daucus carota L. seed extracts possess significant antioxidant potential.

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Protection Against Oxidative Stress and “IGF-I Deficiency Conditions”

Cited by 6 publications

References 136 publications

Mitochondrial stress management: a dynamic journey

Mitochondrial stress management: a dynamic journey

Antioxidant Defence in Labeo rohita to Biotic and Abiotic Stress: Insight from mRNA Expression, Molecular Characterization and Recombinant Protein-Based ELISA of Catalase, Glutathione Peroxidase, CuZn Superoxide Dismutase, and Glutathione S-Transferase

In vitro antioxidant activity‐guided fractionation of Daucus carota L. seed extract

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