Protection against mosquito vectors  Aedes aegypti, Anopheles stephensi  and  Culex quinquefasciatus  using a novel insect repellent, ethyl anthranilate

Islam, Johirul; Zaman, Kamaruz; Tyagi, Varun; Duarah, Sanjukta; Dhiman, Sunil; Chattopadhyay, Pronobesh

doi:10.1016/j.actatropica.2017.06.024

Cited by 31 publications

(18 citation statements)

References 56 publications

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“…By contrast, MNMA—to our knowledge—has not been described from any exocrine gland of arthropods yet. Regarding chemical defense, anthranilate derivatives were described to represent effective repellents against insects such as mosquitos (e.g., Islam et al 2017) and birds (Glahn et al 1989; Clark et al 2000; Müller-Schwarze 2009). For starlings, MNMA is highly aversive, leading to irritations of nerves associated with the olfactory system (Mason et al 1989).…”

Section: Resultsmentioning

confidence: 99%

Methyl N-methylanthranilate: major compound in the defensive secretion of Typhloiulus orpheus (Diplopoda, Julida)

et al. 2017

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The defensive secretion of the julid diplopod Typhloiulus orpheus contains methyl N-methylanthranilate (MNMA), an ester of N-methylanthranilic acid that comprises more than 99% of secretion of this species. MNMA is accompanied by small amounts of methyl anthranilate and two benzoquinones (2-methyl-1,4-benzoquinone and 2-ethyl-1,4-benzoquinone, respectively). MNMA is a known intermediate in the biosynthesis of both benzoquinones (as present in defensive secretions of juliformians) and glomerin-like quinazolines (chemical defense in Glomerida). The compound may have evolved independently in the pathway to glomeridan chemistry, or may even represent a pivotal branching point in the pathway to different chemical classes of diplopod defensive chemistry.

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Section: Resultsmentioning

confidence: 99%

Methyl N-methylanthranilate: major compound in the defensive secretion of Typhloiulus orpheus (Diplopoda, Julida)

et al. 2017

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“…EA provided comparable results to standard repellent DEPA. As a result, the repellent activity of EA is promising for developing effective, safe, and eco-friendly alternative to the existing harmful repellents for personal protection against different mosquito species [34].…”

Section: Ethyl Anthranilatementioning

confidence: 99%

Commercial Mosquito Repellents and Their Safety Concerns

Khater¹,

Selim²,

Abouelella³

et al. 2019

Malaria

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Mosquitoes are serious vectors of diseases threading millions of humans and animals worldwide, as malaria, filariasis, and important arboviruses like dengue, yellow fever, chikungunya, West Nile virus, and Zika viruses. The swift spread of arboviruses, parasites, and bacteria in conjunction with the development of resistance in the pathogens, parasites, and vectors represents a great challenge in modern parasitology and tropical medicine. Unfortunately, synthetic insecticides had led to some serious health and risk concerns. There are no vaccines or other specific treatments for arboviruses transmitted by mosquitoes. Accordingly, avoidance of mosquito bites remains the first line of defense. Insect repellents usually work by providing a vapor barrier deterring mosquitoes from coming into contact with the skin surface, and this chapter focused on assets and liabilities, mechanism of action, improving efficacy, safety, and future perspective of synthetic and natural repellents that could potentially prevent mosquito-host interactions, thereby playing an important role in reducing mosquito-borne diseases when used correctly and consistently.

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“…These mosquito-vectored viruses are responsible for causing many severe human tropical diseases that incapacitate and seriously debilitate millions of people and unfortunately, decimate countless lives annually [11]. In addition, absence of vaccines and the lack of effective medical treatments for some of the diseases further alleviate the sufferings and economic consequences among populations [12]. Overwhelmingly, recent evidences on the involvement of Culex quinquefasciatus mosquitoes to vector zika virus (which is generally considered an Aedes- transmitted pathogen) has raised grave concern [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Development of a validated RP-HPLC/DAD method for the quantitative determination of methyl jasmonate in an insect repellent semi-solid formulation

Islam

Phukan

Chattopadhyay

2019

Heliyon

Self Cite

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A simple and efficient reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the first time for the estimation of a mosquito repellent, methyl jasmonate in a cream formulation, and validated as per the International Conference on Harmonization guidelines. Acetonitrile and water (75:25 v/v) were used as the mobile phase and the flow-rate of the mobile phase was kept constant at 1.0 mL/min. The analysis was performed isocratically on a C 18 analytical column (250 × 4.4 mm, 5 μm) using a Diode Array Detector for the detection of methyl jasmonate at 214 nm. The presence of excipients did not interfere with the quantification of methyl jasmonate. The calibration curve was linear in the concentration range of 25–300 μg/mL. The relative standard deviations for intra-day and inter-day precision, and repeatability were less than 2%. The recovery ranged from 88.5% to 90.7% with relative standard deviations not higher than 2%. The limit of detection and quantification were 9.4 μg/mL and 28.5 μg/mL, respectively. System suitability parameters were within the accepted range. The proposed method was also robust. Thus, the present report puts forward a novel analytical method for the estimation of an emerging mosquito repellent, methyl jasmonate by using the RP-HPLC technique.

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Protection against mosquito vectors Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus using a novel insect repellent, ethyl anthranilate

Cited by 31 publications

References 56 publications

Methyl N-methylanthranilate: major compound in the defensive secretion of Typhloiulus orpheus (Diplopoda, Julida)

Methyl N-methylanthranilate: major compound in the defensive secretion of Typhloiulus orpheus (Diplopoda, Julida)

Commercial Mosquito Repellents and Their Safety Concerns

Development of a validated RP-HPLC/DAD method for the quantitative determination of methyl jasmonate in an insect repellent semi-solid formulation

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