Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases

Ma, Xiaochuan; Lee, Sangyun; Fei, Xingshu; Ge, Fang; Huynh, Tien; Chen, Chunying; Chai, Zhifang; Ge, Cuicui; Zhou, Ruhong

doi:10.1016/j.nantod.2020.100933

Cited by 10 publications

(13 citation statements)

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“…Because vital biomolecules and membranes are electropositive or electronegative, tailoring inherent surface with stable electrostatic charge can accomplish supreme interaction between nanomaterials and charged biomolecules. We found that gold nanoclusters (AuNCs) modified with different surface charges showed opposite effects for proteasome activity, demonstrating different effects on neurodegenerative diseases . In this study, the 20S proteasome activity was regulated by two different forms of peptide tails coated on AuNCs, encoding either negatively or positively charged amino acids in their sequences, marked as AuNC(−) (modified by negatively charged peptide CCYDEDED) and AuNC(+) (modified by positively charged peptide CCYRKRKR).…”

Section: Surface Engineering To Improve the In Vivo Behavior Of Nanom...mentioning

confidence: 92%

“…We found that gold nanoclusters (AuNCs) modified with different surface charges showed opposite effects for proteasome activity, demonstrating different effects on neurodegenerative diseases. 51 In this study, the 20S proteasome activity was regulated by two different forms of peptide tails coated on AuNCs, encoding either negatively or positively charged amino acids in their sequences, marked as AuNC(−) (modified by negatively charged peptide CCYDEDED) and AuNC(+) (modified by positively charged peptide CCYRKRKR). Because of their differences in surface net charge, the two clusters bind to different regions of the 20S proteasome (Figure 5C), therefore either facilitating or impeding the activity of the proteasome.…”

Section: Tailoring Inherent Surface Physicochemical Propertiesmentioning

confidence: 99%

“…(D) Open and closed conformations of the central gate of 20S proteasome after bindging to AuNC(−) and AuNC(+) or not. Reprinted with permission from ref . Copyright 2020 Elsevier Ltd. (E) Affinity ability of GDY and GDYO to STAT3.…”

Section: Surface Engineering To Improve the In Vivo Behavior Of Nanom...mentioning

confidence: 99%

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Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

et al. 2022

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The nano−bio interface refers to the physical interface between the biological system and nanoscale surface topography, functioning as the barrier between two phases where critical reactions occur. In the last two decades, advances in nanofabrication techniques have heralded a new research area utilizing precisely engineered surfaces and structures to control cell cycles, pathways of metabolism, immune responses, and so forth. At the cellular level, engineered nanomaterials (ENMs) with typical surfaces and structures have been shown to actively affect biological responses, such as stimulating macrophage polarization, monitoring reduction−oxidation equilibrium, and manipulating protease activities via tunable nano−bio interactions. In this Account, we outline our recent progress in surface engineering and structural engineering to improve nano−bio interactions and the performance of nanomedicine. To regulate nanomaterial−molecule and nanomaterial−membrane interactions, we summarize the classical types of nano−bio interaction, extract the essential parameters in nanomaterial surface engineering and structural engineering, and propose effective techniques of surface engineering and structural engineering. We start with identifying the types of dominant interactions between nanomedicines and vital biomolecules: nanonucleic acids, nanoproteins, and nanomembranes. The surface engineering strategies of nano−bio interface tailoring are then arranged into four perspectives: the protein corona (the two modes of protein corona formation and their impacts on altering the affinity profiles of nanomaterials to biological systems), thermoresponsive polymers in superficial modification (passive activation by in situ gelation and active regulation by photothermal conversion), stimulus-induced bonding groups (mediation of nanoparticle aggregation to balance the penetration depth and longterm retention), and inherent surface properties (surface roughness for maximized nano−bio adhesion, surface charge for electrostatic attraction and biological barrier penetration of nanoparticles, and skeleton oxidation to boost nano−bio hydrogen bonding). Structural engineering of nanomaterials occurs by remote manipulation through electron-transfer facilitation (doping, heterojunction, defects, and vacancies) of the nano−bio interaction, following multifaceted solutions that combine multiple surface engineering plans. The scopes and limitation section discusses the prospective problems that can occur when nanomaterials/ nanomedicines interact in biological contexts. Because both clinical and laboratory studies have shown the influence of surface topological features on biological responses, the feedback of biological systems to different topographical features of nanomaterials/ nanomedicines is essential for us to comprehend the nano−bio interface at the relevant nanometer length scale. For on-demand nano−bio interactions, the discovery provides insight into the rational design of nanomaterials/nanomedicines.

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Section: Surface Engineering To Improve the In Vivo Behavior Of Nanom...mentioning

confidence: 92%

Section: Tailoring Inherent Surface Physicochemical Propertiesmentioning

confidence: 99%

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Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

et al. 2022

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“…Gold nanoclusters (AuNCs) represent a prominent class of organic–inorganic composite materials. − The unique photoluminescence (PL) properties of AuNCs, such as phosphorescence, size-dependent luminescence, and long wavelength (red/near-infrared) emission, make them promising candidates in various fields, including chemical sensing, bioimaging, and optoelectronic devices. − However, the low quantum yield (QY) restricts their practical applications. Moreover, various tuning strategies to improve the emission properties of AuNCs, enhance the electron density of thiolate ligands, regulate the polarity of solvents, and regulate the ratio of metal atoms to ligands or co-assembly with other molecules have been successfully proposed. − Those strategies could overcome the drawbacks, and materials with a relatively long lifetime of microseconds assigned to phosphorescence can be obtained.…”

Section: Introductionmentioning

confidence: 99%

Luminescence Enhancement of a Gold Nanocluster Hydrogel Facilitated by Water for Erasable Water Writing and Visual Solvent Differentiation

Shen

Liu

et al. 2022

ACS Sustainable Chem. Eng.

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Gold nanoclusters (AuNCs) with an ultrasmall size have attracted enormous interest due to their unique luminescence properties. However, manipulating/improving the luminescence of AuNCs through a convenient method is still challenging. Herein, effective enhancement of emission by simply using water is reported for the AuNCs stabilized by 4,6-diamino-2-pyrimidinethiol (DPT). The DPT-AuNCs could aggregate into a hydrogel in aqueous systems, accompanied with luminescence enhancement (the quantum yield increased from 0.36 to 3.07%). However, the xerogel obtained by freeze-drying was non-luminescent. Addition of water to the xerogel could trigger the emission again. Differential scanning calorimetry, X-ray diffraction, and theoretical calculations reveal that water-bridged hydrogen bonds play crucial roles in the emission of DPT-AuNCs. Furthermore, the water-sensitive luminescence of DPT-AuNCs was applied for developing erasable water writing materials and for visual differentiation of solvents (e.g., protonic organic solvents, non-protonic organic solvents, and water). This study offers a green, cost-effective, and convenient strategy for enhancing the luminescence properties of AuNCs, reveals the crucial role of water molecules in the emission of AuNCs, and presents an application in optoelectronic functional materials.

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“…34 As for the surface charge, Xie's group generated a family of AuNCs with the same number of gold atoms but different surface properties and found that more negatively charged AuNCs would produce more reactive oxygen species (ROS), leading to a higher bacterial killing efficiency. 33 Due to the complexity of the interaction between metal nanoclusters and organisms, 6,[35][36][37][38][39] we speculate that there might exist other factors affecting the antibacterial activity of AuNCs. In this case, atomic-precise AuNCs could provide a good platform to explore the relationship between the structure and biological activity.…”

Section: Introductionmentioning

confidence: 99%

Levonorgestrel-protected Au₈ and Au₁₀ clusters with different antimicrobial abilities

et al. 2022

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Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases

Cited by 10 publications

References 46 publications

Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

Luminescence Enhancement of a Gold Nanocluster Hydrogel Facilitated by Water for Erasable Water Writing and Visual Solvent Differentiation

Levonorgestrel-protected Au₈ and Au₁₀ clusters with different antimicrobial abilities

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Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases

Cited by 10 publications

References 46 publications

Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

Engineering Nano–Bio Interfaces from Nanomaterials to Nanomedicines

Luminescence Enhancement of a Gold Nanocluster Hydrogel Facilitated by Water for Erasable Water Writing and Visual Solvent Differentiation

Levonorgestrel-protected Au8 and Au10 clusters with different antimicrobial abilities

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Levonorgestrel-protected Au₈ and Au₁₀ clusters with different antimicrobial abilities