Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain

Involvement of human heat shock protein 90α in nicotine‐induced apoptosis

“…RSa cells are highly sensitive to apoptosis induced by various agents 7 and were found here to be susceptible to nicotine-induced apoptosis. UVAP-1 cells were established as cells with increased levels of protease activity after UV irradiation 8 and were found here to have increased resistance to nicotine-induced apoptosis.…”

Enhanced Expression of The LDH-A Gene after Gravity-changing Stress in Human RSa Cells.

“…RSa cells have high sensitivity to UV-mutagenicity and cell-killing (Kuwata et al, 1976;Suzuki and Fuse, 1981). In contrast, AP r -1 and HeLa cells are both resistant to UV-induced mutagenicity (Kuwata et al, 1976;Suzuki and Fuse,1981;Isogai et al, 1998;Wang et al, 1999), and the latter cells were further resistant to UV cell-killing (Kuwata et al, 1976;Suzuki and Fuse, 1981) because of their higher repair capacity than RSa cells. However, the gravity-changing stress-induced up-regulation of the LDH-A gene was observed in all the cell lines, and to a similar extent.…”

“…Characteristics of the RSa cell line have been described with regard to high sensitivity to far-ultraviolet light (UVC, principally 254 nm in wavelength)-induced cell-killing and mutagenicity (Kuwata et al, 1976;Suzuki and Fuse, 1981) AP r -1 cells were established as a variant cell line with resistance to the UV mutagenicity as previously described (Isogai et al, 1998;Wang et al, 1999). HeLa cells have been described elswhere (Kuwata et al, 1976;Suzuki and Fuse, 1981).…”

The Roles of HSP27 and Annexin II in Resistance to UVC-Induced Cell Death: Comparative Studies of the Human UVC-Sensitive and -Resistant Cell Lines RSa and APr-1

“…Cells were irradiated with UVC as previously described, 7) and mock-irradiated cells were treated in the same manner but without UVC irradiation.…”

“…6) AP r -1 cells, which are more resistant to UVC-induced cell death, were established from RSa cells by mutagenesis with ethyl methanesulfonate followed by UVC irradiation. 7) The expression of HSP27 was found to be lower in the RSa cells than in the AP r -1 cells. 4…”