Prosthetic valve endocarditis caused by Corynebacterium diphtheriae in a patient with pemphigus vulgaris

Namnyak, Simon S.; Bhat, R P; Al‐Jam'a, Ali H.; Fathalla, Sami E.

doi:10.1128/jcm.25.7.1330-1332.1987

Cited by 15 publications

(1 citation statement)

References 25 publications

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“…There are several reports of endocarditis occurring during or after initiation of immunosuppressive drug therapies in patients with a variety of diseases in the literature (Ihara et al, 2017;Moshkani Farahani et al, 2014), including atopic dermatitis which is a relatively less severe dermatological disease compared to PV (Tanioka, Iwata, Marumoto, & Kaneko, 2015). To the best of our knowledge, there are only two reported cases of patients who developed IE on native valves (Kayrak, Bacaksiz, Gul, & Sonmez, 2011), and one on a prosthetic valve (Namnyak, Bhat, Al-Jama, & Fathalla, 1987) while undergoing PV therapy.…”

Section: Discussionmentioning

confidence: 99%

Infective endocarditis in two patients with pemphigus vulgaris under multiagent immunosuppressive drug therapy: A rare entity to remember in the differential diagnosis of fever of unknown origin

Küçükoğlu

Kılıç

Sun

2019

Dermatologic Therapy

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Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well‐established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow‐up periods may result in various adverse reactions, including bacterial and viral infections. Infective endocarditis (IE) is one of the rarest complications of PV treatment with only a few reported cases. In the present study, the present authors discuss two PV patients without prior histories of cardiovascular disease, complicated with native aortic valve IE, which led to death in one of the patients. Because determining the origin of fever is difficult in patients under immunosuppressive therapy, it is particularly challenging to diagnose IE coupled with a fever of unknown origin. Therefore, dermatologists must be vigilant for the dermatological signs of IE and use a multidisciplinary approach to the differential diagnosis of fever of unknown origin.

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Section: Discussionmentioning

confidence: 99%