Prosthetic Replacement of the Ocular Surface Ecosystem as Treatment for Ocular Surface Disease in Patients with a History of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis

Papakostas, Thanos D.; Le, Hong-Gam; Chodosh, James; Jacobs, Deborah S.

doi:10.1016/j.ophtha.2014.08.015

Cited by 60 publications

(47 citation statements)

References 29 publications

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“…Over the past decade, there has been a growing interest in using ScL for the protection of the ocular surface [49][50][51][52][53][54][55][56][57] due to advances in CL materials and oxygen permeability [29,34,[53][54][55][56][57]. The vaulting of the cornea and conjunctiva is believed to prevent evaporation and the tear reservoir maintains direct contact between tears and corneal tissue in addition to playing the role of protecting the cornea from possible abrasion from eyelid conjunctiva irregularities or trichiasis [38,58].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the influence of corneo-scleral and scleral lenses on ocular surface and tear film metrics in a presbyopic population

Lafosse

Romín

Esteve-Taboada

et al. 2018

Contact Lens and Anterior Eye

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Section: Discussionmentioning

confidence: 99%

Comparison of the influence of corneo-scleral and scleral lenses on ocular surface and tear film metrics in a presbyopic population

Lafosse

Romín

Esteve-Taboada

et al. 2018

Contact Lens and Anterior Eye

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“…Once ocular surface integrity is established and inflammation reduced, stromal remodeling can occur through a prolonged process of synthesis, degradation and resynthesis. 1 , 8 , 9 , 10 , 11 Clearing of corneal opacity has been of feature of cases depicted in other reports of PROSE treatment from this center, 18 , 21 , 34 but clearing of opacity was not the specific focus of those reports. In those depicted cases, PROSE treatment was used in conjunction with other interventions, such as topical corticosteroids, that might account for clearing of opacity and improvement in vision.…”

Section: Discussionmentioning

confidence: 85%

“…While visual rehabilitation of corneal opacity with RGP contact lenses, 13 scleral lenses 14 , 15 , 16 , 17 , 18 , 19 and PROSE treatment 20 , 21 , 22 , 23 has been described, we believe that a role for therapeutic lenses for the clearing or resolution of chronic corneal opacity in the setting of ocular surface disease is not appreciated and has never been reported. We present a series of four cases of resolution of chronic corneal opacity and improvement of visual acuity with PROSE treatment.…”

Section: Introductionmentioning

confidence: 94%

Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment

Cressey

Jacobs

Remington

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeTo demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease.ObservationsWe undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients were referred for ocular surface disease of various etiologies. Primary inclusion criterion was corneal opacity that improved with PROSE treatment. Patients were excluded if topical steroids or adjuvant therapy used once PROSE treatment was initiated. Underlying disease, prior treatment, clinical presentation, and clinical course were extracted from the medical record. Four patients are included in this series. There were three females and one male; median age at time of treatment initiation was 30 years (range = 0.5–58 years). Median duration of PROSE treatment at time of retrospective analysis was 3.5 years (range = 1–8 years). Two cases had corneal opacification in the context of neurotrophic keratopathy: a unilateral case due to presumed herpes simplex keratitis and a bilateral case due to congenital corneal anesthesia associated with familial dysautonomia. One case had corneal opacity from exposure related to seventh nerve palsy, and one had corneal opacification associated with recurrent surface breakdown, neurotrophic keratopathy, and limbal stem deficiency of uncertain etiology. After consistent wear of prosthetic devices used in PROSE treatment for support of the ocular surface, visual acuity improved and clearing of the opacities was observed, without use of topical steroids or adjuvant therapy.Conclusions and importanceThese cases demonstrate clearing of chronic corneal opacity with PROSE treatment for ocular surface disease. This clearing can occur with no adjuvant therapy, suggesting that restoration of ocular surface function and integrity allows for corneal remodeling.

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“…4 Other studies showed a much lower rate of abandoning ScCL due to handling problems. [5][6][7][8][9][10] One study broke down handling difficulty establishing that with application, 20% of patients had mild difficulty while 12% had moderate difficulty; and with removal, only 9% of patients had mild difficulty. 11 Kornberg and Wang found that application and removal was not a laborious process.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Whereas, other studies have debunked difficulties with ScCL handling. 1,[5][6][7][8][9][10][11][12] ScCL complications related to handling are rare and most are managed without any lasting side-effects. It is crucial that patients understand the application and removal process and are trained in handling ScCL as patients may have initial difficulty with this process.…”

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confidence: 99%

Scleral Lens Issues and Complications Related to Handling, Care and Compliance

Fadel

Toabe

2018

JCLRS

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Scleral contact lens (ScCL) handling may be challenging and is the principle reason for ScCL drop out. ScCL care systems are more intricate than other lens modalities and include solutions for cleaning, disinfection, storing, rinsing and filling the lens; respecting the use of each solution recommended is fundamental. Replacement of the lenses, solutions, case and plungers are important in order to decrease the risk of adverse events associated with ScCL wear. Compliance is crucial regarding hygiene, solution use, case and plunger care, wear time, follow-up schedule, and handling techniques. Non-compliance may lead to discontinuation of ScCL due to difficulties associated with this unique lens design. This paper presents complications secondary to handling, care and compliance that clinicians and patients may encounter while wearing ScCL. Instructions are provided to enhance the understanding on management surrounding these issues. This manuscript includes three tables to summarize types of complications, their symptoms, clinical signs, etiology, and management for a quick find index for easy consultation during daily clinical practice.

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Prosthetic Replacement of the Ocular Surface Ecosystem as Treatment for Ocular Surface Disease in Patients with a History of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis

Cited by 60 publications

References 29 publications

Comparison of the influence of corneo-scleral and scleral lenses on ocular surface and tear film metrics in a presbyopic population

Comparison of the influence of corneo-scleral and scleral lenses on ocular surface and tear film metrics in a presbyopic population

Improvement of chronic corneal opacity in ocular surface disease with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment

Scleral Lens Issues and Complications Related to Handling, Care and Compliance

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