The purpose of this study was to evaluate factors that impact outcome following repair of type A aortic dissection. Over 25 years , 252 patients underwent repair of acute type A dissection. Mean follow-up for reoperation or death was 6.9AE5.9 years. Operative mortality was 16% (41 of 252). Multivariate analysis identified one risk factor for operative death: presentation malperfusion (P=.003). For operative survivors, 5-, 10-, and 20-year survival was 78%AE3%, 59%AE4%, and 24%AE6%, respectively. Late death occurred earlier in patients with previous stroke (P=.02) and chronic renal insufficiency (P=.007). Risk factors for late reoperation included male sex (P=.006), Marfan syndrome (P<.001), elevated systolic blood pressure (SBP, P<.001), and absence of b-blocker therapy (P<.001). Kaplan-Meier analysis demonstrated at 10-year follow-up that patients who maintained SBP <120 mm Hg had improved freedom from reoperation (92AE5%) compared with those with SBP 120 mm Hg to 140 mm Hg (74%AE7%) or >140 mm Hg (49%AE14%, P<.001). At 10-year follow-up, patients on b-blocker therapy experienced 86%AE5% freedom from reoperation compared with only 57%AE11% for those without (P<.001).Operative survival was decreased with preoperative malperfusion. Long-term survival was dependent on comorbidities but not operative approach. Reoperation was markedly increased in patients not on b-blocker therapy and decreased with improved SBP control. Strict control of hypertension with b-blocker therapy is warranted following repair of acute type A dissection. J Clin Hypertens (Greenwich). 2013; 15:63-68. Ó2012 Wiley Periodicals, Inc.Despite contemporary surgical advances, patients with acute type A aortic dissection still present significant operative challenges both in terms of short-and longterm outcomes. Reported operative mortality rates are high (15%-28%) with stroke rates of 2% to 15%.