Prostheses size dependency of the mechanical response of the herniated human abdomen

Simón-Allué, Raquel; Hernández-Gascón, Belén; Leoty, Laura; Bellón, Juan M.; Peña, Estefanía; Calvo, Begoña

doi:10.1007/s10029-016-1525-3

Cited by 14 publications

(2 citation statements)

References 31 publications

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“…In this respect, our group has made contributions in the field of biomechanics showing that PP-LW meshes such as Optilene [ 30 ] displayed a mechanical response similar to healthy muscle. Numerical simulations models of reconstructed herniated human abdominal wall based on abdomen geometry obtained by magnetic resonance imaging support this theory, as they have shown that these LW meshes showed the closest deformation to the natural distensibility of the abdomen [ 33 ]. Optimal clinical results in abdominal hernia repair strongly depend on a perfect match between the mechanical properties of the abdominal wall and those of the biomaterial used for repair in the long term [ 34 ].…”

Section: Discussionmentioning

confidence: 96%

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

et al. 2018

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IntroductionLightweight (LW) polypropylene (PP) meshes better adapt to host tissue, causing less fibrosis and inflammatory responses than high-density meshes. Mesh fixation using tissue adhesives (TA) that replace conventional sutures may improve the process of hernia repair and tissue trauma. This preclinical study compares the behavior of different cyanoacrylate-based adhesives in the fixation of LW-PP meshes for hernia repair.MethodsPartial abdominal wall defects were repaired using LW-PP Optilene meshes in New Zealand rabbits. The following groups were established according to the mesh fixation method: Suture (control), Glubran 2 (n-butyl), Ifabond (n-hexyl), SafetySeal (n-butyl) and Evobond (n-octyl). At 14, 90 and 180 days after surgery, the recovered implants were examined to assess the host tissue integration, the macrophage response and the biomechanical strength.ResultsAll the groups showed optimal host tissue incorporation regardless of the fixation procedure. Significantly increased levels of collagen 1 and collagen 3 gene expression (p<0.001) were observed at 14 days compared to the medium- and long-term durations, where the Suture and Glubran groups showed the highest expression of collagen 1. All the adhesives increased the macrophage reaction (p<0.001) compared to sutures at all implant times. Maximal macrophage response was observed in the short-term Glubran group (p<0.01) compared to the rest of the groups. Although SafetySeal and Evobond did not reach the biomechanical resistance of sutures at 14 days, all the adhesives did reach this level in the medium- to long-term periods, providing significantly higher resistance (p<0.05).ConclusionsAll the cyanoacrylates, despite inducing a significantly increased macrophage response versus sutures, showed optimal host tissue integration and long-term mechanical behavior; thus, they might be good choices for LW-PP mesh hernia repairs.

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Section: Discussionmentioning

confidence: 96%

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

et al. 2018

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“…Thus the mechanical behaviour of surgical meshes and abdominal tissues has been studied and reported in literature (see extensive review of Deeken and Lake, 2017). Compatibility between an implant and an abdominal wall can be assessed experimentally (Junge et al, 2001;Anurov et al, 2012) according to various criteria (Maurer et al, 2014) or by computer simulations (Simón-Allué et al, 2016;Todros et al, 2018;He et al, 2020). The computational approach allows for in silico testing of various cases and empowers optimisation of ventral hernia treatment (Szymczak et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

A novel in vivo approach to assess strains of the human abdominal wall under known intraabdominal pressure

Lubowiecka,

Szepietowska,

Tomaszewska

et al. 2021

Preprint

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The study concerns mechanical behaviour of a living human abdominal wall.A better mechanical understanding of a human abdominal wall and recognition of its material properties is required to find mechanically compatible surgical meshes to significantly improve the treatment of ventral hernias.A non-invasive methodology, based on in vivo optical measurements is proposed to determine strains of abdominal wall corresponding to a known intraabdominal pressure. The measurement is performed in the course of a standard procedure of peritoneal dialysis. A dedicated experimental stand is designed for the experiment. The photogrammetric technique is employed to recover the three-dimensional surface geometry of the anterior abdominal wall at the initial and terminal instants of the dialysis. This corresponds to two deformation states, before and after filling the abdominal cavity with dialysis fluid.The study provides information on strain fields of living human abdominal wall. The inquiry is aimed at principal strains and their directions, observed at the level from -10% to 17%. The intraabdominal pressure related to the amount of introduced dialysis fluid measured within the medical procedure covers the

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Constitutive Modelling of Knitted Abdominal Implants in Numerical Simulations of Repaired Hernia Mechanics

Tomaszewska

Reznikov

Szymczak

et al. 2020

Lecture Notes in Computational Vision and Biomechanics

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Prostheses size dependency of the mechanical response of the herniated human abdomen

Cited by 14 publications

References 31 publications

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

A novel in vivo approach to assess strains of the human abdominal wall under known intraabdominal pressure

Constitutive Modelling of Knitted Abdominal Implants in Numerical Simulations of Repaired Hernia Mechanics

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