Prostatic signet‐ring cell carcinoma: Case report and literature review

Abstract

Signet-ring cell carcinoma (SRCC) of the prostate is a very rare neoplasm and there have been only 38 cases reported to date. Here the 39th case of prostatic SRCC containing a small amount of neutral mucin, prostatic specific antigen (PSA) and prostatic specific acid phosphatase (PSAP) in the signet-ring cells is reported. It was also found that some intracytoplasmic lumina were derived from the shallow or deep invagination of luminal membranes of cancer cells that formed the neoplastic glands. Using immunohistochemistry, a combination of monoclonal antibodies against cytokeratins 7 and 20 as well as PSA and PSAP may be useful in differentiating prostatic primary SRCC from metastatic SRCC originating in the gastrointestinal tract.

Potent Phagocytic Activity Discriminates Metastatic and Primary Human Malignant Melanomas: A Key Role of Ezrin

“…The novelty of our data is the demonstration that this phagocytic activity does not merely account for the ability of malignant tumor cells to nibble the extracellular matrix or cell debris (Banerjee and Harris, 2000; Kuroda et al, 1999), but to actively engulf, ingest, and digest apoptotic cells. This mechanism may contribute to the typical ability of malignant tumor cells to survive in the lack of trophic supply, both in vivo and in vitro.…”

“…Moreover, other histopathologic signs of tumor malignancy, recalling an in vivo phagocytic-like behavior of tumor cells, have been described. Between the above mentioned signs there are the so-called "signet-ring cells," mostly typical of adenocarcinoma (Kuroda et al, 1999) and characterized by the presence of intracytoplasmic mucin displacing the nucleus. However, signet-ring cells can also be found in nonepithelial tumors, such as malignant lymphomas and melanomas (Tsang et al, 1992).…”

“…However, signet-ring cells can also be found in nonepithelial tumors, such as malignant lymphomas and melanomas (Tsang et al, 1992). The nature of these cells, particularly in nonepithelial tumors, is not known, but it is conceivable that an aberrant scavenging activity underlies this phenomenon (Banerjee and Harris, 2000;Kuroda et al, 1999). Altogether these reports suggest that active phagocytosis occurs in human tumor cells, but the phagocytic apparatus of tumor cells has never been defined and the mechanism(s) underlying this phenomenon have not been investigated.…”

Unusual subtypes of prostate cancer

“…Designation as a signet ring cell carcinoma is restricted to those cases where the signet ring cells make up over 25% of the tumor volume, although a wide range of definitions have been applied. [31][32][33][34][35][36][37][38] Clinically, these tumors are typically of advanced stage at the time of diagnosis. 15,26,36 Serum PSA is usually significantly elevated.…”

Nadir bir prostat kanseri: Primer taşlı yüzük hücreli adenokarsinom

“…Bu hastaların yaş ortalaması 68.2 yıldır (1). Klasik prostat adenokarsinomlara göre daha kötü prognoza sahiptirler (5). Bu yazıda, tespit edildiğinde ileri evrede olan, klasik adenokarsinomda uygulanan antihormonal tedaviye çok iyi yanıt vermeyen ve kısa sürede yükselen prostat spesifik antijen (PSA) düzeyi nedeniyle kemoterapi başlanan prostatın taşlı yüzük hücreli adenokarsinomu olgusu sunulmaktadır. )…”