Prostatic adenocarcinoma (PCa) metastasizing to renal cell carcinoma (RCC) with periureteral tumor deposit: A case of tumor-to-tumor metastasis (TTM)

Arceño, Jenissa Amor; Mendoza, Jonathan S.; Castillo, Josefino C.; So, Jeffrey

doi:10.1016/j.ehpc.2017.01.002

Cited by 1 publication

(3 citation statements)

References 15 publications

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“…I have reviewed 19 cases, which are briefly summarized in Tab. 2 [1,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], includ ing this present case. The mean age of the patients was 66 years (range 42-97 years).…”

Section: Discussionmentioning

confidence: 96%

“…The pathologist suggested a primary origin in the pancreatobiliary [5][6][7][8][9][10][11]. The donor tumor is most often the carcinoma of the lung [5][6][7][8][9][10][11]. The reason for the high incidence of clear cell RCC as a recipient for TTM is unclear, however, both theories described previously seem to be involved.…”

Section: Discussionmentioning

confidence: 99%

“…The reason for the high incidence of clear cell RCC as a recipient for TTM is unclear, however, both theories described previously seem to be involved. First, as the clear cell RCC contains a large amount of glycogen and lipids, this may provide a nutrientrich microenvironment for hom ing of metastatic tumor cells [7,8,10,11]. Second, because it is typically hypervascular and the kidney per se receive a significant blood flow, a large number of circulat ing neoplastic cells shed from a donor cancer may enter the tumor [7,8,10,11].…”

Section: Discussionmentioning

confidence: 99%

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Tumor-to-Tumor Metastasis – a Unique Case of Clear Cell Renal Cell Carcinoma Harbor ing Metastasis of Adenocarcinoma of Unknown Origin

Bartoš¹

2018

Klin Onkol

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Background: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin. Case: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. A histology of lesion in the kidney revealed a conventional clear cell renal cell carcinoma (RCC) harbor ing multiple metastatic foci of another adenocarcinoma. At that time, there was not possible to reliably specify a primary source. Subsequently, a probatory excision of tumor lesion in the liver was also done. A microscopy confirmed an adenocarcinoma with a similar appearance as found in RCC. Due to unfavourable health condition, a paliative chemother apy could not be realized and the patient died shortly thereafter. A primary origin of adenocarcinoma remained unclear. Conclusion: A unique case of metastatic adenocarcinoma is described, that was initially dia gnosed as an incidental find ing within a clear cell RCC of the kidney. Such unexpected feature may represent a great dia gnostic challenge for both, pathologist and clinician. From a prognostic point of view, an evidence of intratumoral cancer metastasis within a primary RCC is usually an indicator of disseminated oncologic dis ease with a poor outcome.

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