Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles

Katti, Kattesh V.; Khoobchandani, Menka; Thipe, Velaphi C.; Al-Yasiri, Amal Yousif; Loyalka, Sudarshan K.; Sakr, Tamer M.; Lugão, Ademar B.

doi:10.1007/s10967-018-6320-4

Cited by 34 publications

(43 citation statements)

References 41 publications

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“…For example, AuNPs are used in biosensor development for signal amplification owing to their optical and electrochemical sensing capabilities 51. Moreover, AuNPs have demonstrated promise in the advancement of cancer treatment by inhibiting cell proliferation, activating a cascade of pathways to induce apoptosis,25,26,31,35,38,40,42,52 affecting mitochondrial functioning and inhibiting cell migration 53–60. Despite considerable past efforts in the diagnosis and therapy of cancer, there is still a continuing pursuit toward discovering effective modalities that limit the side effects caused by current treatments.…”

Section: Resultsmentioning

confidence: 99%

Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

Thipe

Amiri

Bloebaum

et al. 2019

IJN

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Background: As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology. Method: Resveratrol was used to reduce Au 3+ to Au 0 for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers. Results: This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs. Conclusion: The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

Thipe

Amiri

Bloebaum

et al. 2019

IJN

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“…Katti et al demonstrated a novel approach to treat prostate cancer with 198 Au NPs, which were modified with glucoside molecules mangiferin. In vivo experiments on severe combined immunodeficient (SCID) mice revealed over 85% reduction of bearing prostate tumor volume as compared to the control groups [201].…”

Section: Introductionmentioning

confidence: 99%

Current outlook on radionuclide delivery systems: from design consideration to translation into clinics

et al. 2019

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Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.

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“…As part of our continued quest to develop scientific rationale for Ayurvedic medicine, we have been researching, for over two decades, on the application of green nanotechnology to develop universally acceptable Ayurvedic formulations. [19][20][21][22][23][24][25][26] Green nanotechnology allows the production and efficient encapsulation of Ayurvedic-relevant phytochemicals on gold nanoparticles. Our long-standing scientific efforts, with a focus on gold nanoparticles, are based on the rationale that in Ayurvedic medicine, gold metal is ubiquitously used in combination with phytochemicals from various herbs including cinnamon, clove, gooseberry, grape, mango, turmeric and a host of herbs.…”

Section: Introductionmentioning

confidence: 99%

“…Our long-standing scientific efforts, with a focus on gold nanoparticles, are based on the rationale that in Ayurvedic medicine, gold metal is ubiquitously used in combination with phytochemicals from various herbs including cinnamon, clove, gooseberry, grape, mango, turmeric and a host of herbs. [19][20][21][22][23][24][25][26] Our efforts, serendipitously, led to a series of discoveries confirming that the phytochemicals used in Ayurvedic medicines are indeed electron-rich antioxidants and that the interaction of gold metallic precursors with phytochemically-harnessed electrons produced herb/ phytochemicals-encapsulated, well-defined, gold nanoparticles. The large surface area of gold nanoparticles embedded with atomically active nano surface motif allowed highly efficient encapsulation of phytochemical-(s)thus paving, for the first time, an innovative green nanotechnology route providing reproducible and scientifically verifiable Nano-Ayurvedic formulations.…”

Section: Introductionmentioning

confidence: 99%

“…The large surface area of gold nanoparticles embedded with atomically active nano surface motif allowed highly efficient encapsulation of phytochemical-(s)thus paving, for the first time, an innovative green nanotechnology route providing reproducible and scientifically verifiable Nano-Ayurvedic formulations. [19][20][21][22][23][24] Choice of gold nanoparticles is further necessitated by the fact that this metal embodies the iconic Ayurvedic medication "Swarna Bhasma" (SB) ("Swarna" meaning gold, "Bhasma" meaning ash) which contains gold particles along with various herbal mixtures. Swarna Bhasma is an ancient Indian medicine with established anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

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New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine – Pre-Clinical and Pilot Human Clinical Investigations

Khoobchandani

Katti

Karikachery

et al. 2020

IJN

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The overarching objective of this investigation was to investigate the intervention of green nanotechnology to transform the ancient holistic Ayurvedic medicine scientifically credible through reproducible formulations and rigorous pre-clinical/clinical evaluations. Methods: We provide, herein, full details: (i) on the discovery and full characterization of gold nanoparticles-based Nano Swarna Bhasma (henceforth referred to as NSB drug); (ii) In vitro anti-tumor properties of NSB drug in breast tumor cells; (iii) pre-clinical therapeutic efficacy studies of NSB drug in breast tumor bearing SCID mice through oral delivery protocols and (iv) first results of clinical translation, from mice to human breast cancer patients, through pilot human clinical trials, conducted according to the Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (abbreviated as AYUSH) regulatory guidelines of the Government of India in metastatic breast cancer patients. Results: The preclinical in vitro and in vivo investigations, in breast tumor bearing mice, established unequivocally that the NSB Nano-Ayurvedic medicine-gold nanoparticles-based drug is highly effective in controlling the growth of breast tumors in a dose dependent fashion in vivo. These encouraging pre-clinical results prompted us to seek permission from the Indian Government's holistic medicine approval authority, AYUSH, for conducting clinical trials in human patients. Patients treated with the NSB drug capsules along with the "standard of care treatment" (Arm B) exhibited 100% clinical benefits when compared to patients in the treatment Arm A, thus indicating the tremendous clinical benefits of NSB drug in adjuvant therapy. Conclusion: We have succeeded in clinically translating, from mice to humans, in using proprietary combinations of gold nanoparticles and phytochemicals to develop the Nano-Ayurvedic drug: Nano Swarna Bhasma (NSB), through innovative green nanotechnology, for treating human metastatic breast cancer patients.

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Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles

Cited by 34 publications

References 41 publications

<p>Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers</p>

<p>Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers</p>

Current outlook on radionuclide delivery systems: from design consideration to translation into clinics

<p>New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine – Pre-Clinical and Pilot Human Clinical Investigations</p>

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