Prostate mechanical imaging: 3-D image composition and feature calculations

Egorov, Vladimir; Ayrapetyan, S.; Sarvazyan, Armen

doi:10.1109/tmi.2006.880667

Cited by 61 publications

(51 citation statements)

References 51 publications

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“…The shape of subcutaneous tumors is assumed to be a three-dimensional hemi-ellipsoid [14,15]. Hence, in our study we calculated the tumor volumes by a typical three-dimensional formula for ellipsoid-like tumor volume evaluation: V = π : 6 x L x W x H. The results were confirmed by applying the two-dimensional formula for evaluation of the same tumor volumes, recently proposed by Feldman et al [16]: V = π : 6 x ƒ(L x W) 3/2 .…”

Section: Establishing the Optimal Time Regimen For Rhodamine-6g Injecmentioning

confidence: 99%

Low concentrations of Rhodamine-6G selectively destroy tumor cells and improve survival of melanoma transplanted mice

Kutushov

Gorelik²

2013

neo

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Rhodamine-6G is a fluorescent dye binding to mitochondria, thus reducing the intact mitochondria number and inhibiting mitochondrial metabolic activity. Resultantly, the respiratory chain functioning becomes blocked, the cell "suffocated" and eventually destroyed. Unlike normal cells, malignant cells demonstrate a priori reduced mitochondrial numbers and aberrant metabolism. Therefore, a turning point might exist, when Rhodamine-induced loss of active mitochondria would selectively destroy malignant, but spare normal cells. Various malignant vs. non-malignant cell lines were cultured with Rhodamine-6G at different concentrations. In addition, C57Bl mice were implanted with B16-F10 melanoma and treated with Rhodamine-6G at different dosage/time regimens. Viability and proliferation of cultured tumor cells were time and dose-dependently inhibited, up to 90%, by Rhodamine-6G, with profound histological signs of cell death. By contrast, inhibition of normal control cell proliferation hardly exceeded 15-17%. Melanoma-transplanted mice receiving Rhodamine-6G demonstrated prolonged survival, improved clinical parameters, inhibited tumor growth and metastases count, compared to their untreated counterparts. Twice-a-week 10 -6 M Rhodamine-6G regimen yielded the most prominent results. We conclude that malignant, but not normal, cells are selectively destroyed by low doses of Rhodamine-6G. In vivo, such treatment selectively suppresses tumor progression and dissemination, thus improving prognosis. We suggest that selective anti-tumor properties of Rhodamine-6G are based on unique physiologic differences in energy metabolism between malignant and normal cells. If found clinically relevant, low concentrations of Rhodamine-6G might be useful for replacing, or backing up, more aggressive nonselective chemotherapeutic compounds. Key words: warburg effect, tumor, cell culture, melanoma, rhodamine-6G, mitochondriaCancer cells are unique in their energy turnover. Unlike normal tissues that derive most of their energy by metabolizing the consumed sugar to carbon dioxide and water (the process taking place within mitochondria), tumors obtain as much as half of their ATP by metabolizing glucose directly to lactic acid. Normal tissues use the process of oxidative phosphorylation within mitochondria for 90% of ATP production, and only 10% is produced by glucose consumption. By contrast, in tumor cells this ratio is 50%:50% [1][2][3]. This unique pattern of tumor metabolism has been described in early thirties of the past century and has been recognized since then as Warburg effect [1][2][3]. Recent studies employing molecular biology and proteomic imaging technologies, explained the basics of Warburg effect [4,5].Rhodamine-6G is a fluorescent dye capable of penetrating a living cell [6]. Upon entering the cell, Rhodamine-6G binds to the inner membranes of mitochondria. Based on these observations, it has been proposed that Rhodamine dyes may be used for producing fluorescent images of mitochondria with low background noise and high re...

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Section: Establishing the Optimal Time Regimen For Rhodamine-6g Injecmentioning

confidence: 99%

Low concentrations of Rhodamine-6G selectively destroy tumor cells and improve survival of melanoma transplanted mice

Kutushov

Gorelik²

2013

neo

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“…A second challenge is the subsequent computer processing of the transduced data to obtain useful information (tactile data processing). Approaches have included vision-based processing [6,26], neural networks [5], and solid mechanics modeling [9,10], but a rigorous comparison of methods is lacking. A final challenge is determining the most effective means for relaying the tactile information to a human user (tactile display).…”

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confidence: 99%

Human vs. robotic tactile sensing: Detecting lumps in soft tissue

Gwilliam

Pezzementi

Jantho

et al. 2010

2010 IEEE Haptics Symposium

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Humans can localize lumps in soft tissue using the distributed tactile feedback and processing afforded by the fingers and brain. This task becomes extremely difficult when the fingers are not in direct contact with the tissue, such as in laparoscopic or robot-assisted procedures. Tactile sensors have been proposed to characterize and detect lumps in robot-assisted palpation. In this work, we compare the performance of a capacitive tactile sensor with that of the human finger. We evaluate the response of the sensor as it pertains to robot-assisted palpation and compare the sensor performance to that of human subjects performing an equivalent task on the same set of artificial tissue models. Furthermore, we investigate the effects of various tissue parameters (lump size, lump depth, and surrounding tissue stiffness) on the performance of both the human finger and the tactile sensor. Using signal detection theory for determining tactile sensor lump detection thresholds, the tactile sensor outperforms the human finger in a palpation task.

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“…Human tumor shape was assumed to be a hemiellipsoid using method-1 in glioma [17], breast [18], prostate [19,20], as well as the available segmentation methods. Fig.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Volumetric Brain Tumor Measurements Using Different Manual Methods

Elywa

2018

Arab Journal of Nuclear Sciences and Applications

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Early detection of a minor tumor size change is difficult using traditional visual and clinical examination measurements. Although they are time-consuming, the general manual methods are the standard approach for quantitative measurement of human tumor and used in several hospitals. Magnetic Resonance Imaging (MRI) techniques are used to measure the human tumor volume manually or automatically. Three mathematical manual methods are used to calculate different tumor sizes. The study group consists of twenty-two patients with different tumor types (meningioma, glioblastoma, abscess, metastases, and glioma). All patients were scanned and all the MRI data acquired at 1.5 Tesla with diagnosis histological confirmation. The results of this study show that the triangle mathematical method (method -3) is more accurate than the other compared manual methods. The correlation shows a linear relationship between the mean values of method-1 and method-2 has R2 = 0.7975 and the P-value = 0.026 indicates the significance difference between method-1 and method-2. Moreover, the correlation between method-1 and method-3 has R2 = 0.9367 and the P-value = 0.003 that indicates high significance between them. The comparative study of the three manual methods demonstrated that triangle manual method (method-3) has significant approach to be used in medical diagnosis. Additionally, method-3 can indicate which part of the tumor tissue is totally damaged depending on the image parameters. Therefore, the triangle manual method can be considered as an accurate step in the diagnostic process.

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Prostate mechanical imaging: 3-D image composition and feature calculations

Cited by 61 publications

References 51 publications

Low concentrations of Rhodamine-6G selectively destroy tumor cells and improve survival of melanoma transplanted mice

Low concentrations of Rhodamine-6G selectively destroy tumor cells and improve survival of melanoma transplanted mice

Human vs. robotic tactile sensing: Detecting lumps in soft tissue

A Comparative Study of Volumetric Brain Tumor Measurements Using Different Manual Methods

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